ID A0A0Q3QBR9_AMAAE Unreviewed; 1176 AA.
AC A0A0Q3QBR9;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Thrombospondin-1 {ECO:0000313|EMBL:KQK85612.1};
GN ORFNames=AAES_38879 {ECO:0000313|EMBL:KQK85612.1};
OS Amazona aestiva (Blue-fronted Amazon parrot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQK85612.1, ECO:0000313|Proteomes:UP000051836};
RN [1] {ECO:0000313|EMBL:KQK85612.1, ECO:0000313|Proteomes:UP000051836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQK85612.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thrombospondin family.
CC {ECO:0000256|ARBA:ARBA00009456}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQK85612.1}.
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DR EMBL; LMAW01000736; KQK85612.1; -; Genomic_DNA.
DR STRING; 12930.A0A0Q3QBR9; -.
DR Proteomes; UP000051836; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 6.20.200.20; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 3.
DR Gene3D; 4.10.1080.10; TSP type-3 repeat; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR003367; Thrombospondin_3-like_rpt.
DR InterPro; IPR017897; Thrombospondin_3_rpt.
DR InterPro; IPR008859; Thrombospondin_C.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR028974; TSP_type-3_rpt.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR10199; THROMBOSPONDIN; 1.
DR PANTHER; PTHR10199:SF78; THROMBOSPONDIN-1; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF00090; TSP_1; 3.
DR Pfam; PF02412; TSP_3; 7.
DR Pfam; PF05735; TSP_C; 1.
DR Pfam; PF00093; VWC; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00209; TSP1; 3.
DR SMART; SM00210; TSPN; 1.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF103647; TSP type-3 repeat; 3.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 3.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS50092; TSP1; 3.
DR PROSITE; PS51234; TSP3; 4.
DR PROSITE; PS51236; TSP_CTER; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00634}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Reference proteome {ECO:0000313|Proteomes:UP000051836};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1176
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006206773"
FT DOMAIN 322..379
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 553..593
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 652..696
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 733..768
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT REPEAT 792..827
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT REPEAT 889..924
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT REPEAT 925..960
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT DOMAIN 964..1176
FT /note="TSP C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51236"
FT REGION 730..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 780..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 830..953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..755
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 844..874
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 889..903
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 927..944
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1176 AA; 129722 MW; DA8B5B83C1B9CF20 CRC64;
MGPTAALCLL LLLSGSEARR TAESRSDDNS VFDLFELIGL IRKGAGRRAP GVHLVKGPES
SSPAYRIEDA SRIPPVPDSK FQDLLDAIHT EKGFILLATL RQAKKSRGTL LSVEQKDGSG
HVFSLVSNGK AGTLDLSLXG DGKQQIVSVE DALLATGHWK NITLFVQEDR AQLYVGCEKM
ENAELDIPIQ NIFTRDLASS ARLRIAKGGV NDNFQGLLQN VRFVFGTTLE TILRNKGCSS
STSAIITLDN PINGSSPAIR TNYIGHKTKD IQAVCGFSCD ELTNMFVELQ GLRSMVTTLQ
DRVRKVTEEN ELIAKVVQIT PGVCIHNGIL HKNKEEWTID SCTECTCQNS ATICRKVSCP
LMPCSNATVP DGECCPRCWP SDYADDGWSP WSEWTSCSVT CGNGIQQRGR SCDSLNNRXE
GSSVQTRTCH LQECDKRFKQ DGGWSHWSPW SSCSVTCGTG IITRIRLCNS PVPQLNGKPC
EGEARENKPC QKDPCPINGN WGPWSPWDAC TVTCGGGLQK RSRLCNNPEP QYGGKTCVGE
ARGTQVCNKQ DCPIDGCLSN PCFAGTTCTS SPDGSWKCGA CPPGYHGDGI HCQDIDECKE
VPDACFVFNG VHRCENTEPG YNCLPCPPRF TGTQPFGRSV EDAMANKQVC KPRNPCTDGT
HDCNKNAKCN YLGHFSDPMY RCECKPGYAG NGIICGEDTD LDGWPNENLV CVANATYHCK
KDNCPDLPNS GQXDYDKDGV GDACDNDDDD DGIPDDRDNC PFIYNPQQYD YDRDDVGDRC
DNCPYNHNPD QTDTDNNGEG DACAVDIDGD GVLNEMDNCQ YVYNVDQRDT DLDGVGDQCD
NCPLEHNPDQ EDADSDRIGD QCDNNQDIDE DGHQNNLDNC PYVPNANQAD HDKDGKGDAC
DHDDDNDGIP DDKDNCRLVA NPDQADSDGD GRGDACKXDF DQDSVPDIDD ICPENVDISE
TDFRKFQMIP LDPKGTSQND PNWVVRHQGK ELVQTVNCDP GLAVGFDEFN AVDFSGTFFI
NTERDDDYAG FVFGYQSSSR FYVVMWKQIT QSYWDSTPTK AQGYSGLSIK VVNSTTGPGE
HLRNALWHTG NTPGQVRTLW HDPRHIGWKD FTAYRWRLSH RPKTGYIRVV MYEGKKIMAD
SGPIYDKTYA GGRLGLFVFS QEMVFFSDLK YECRDP
//
