ID A0A0Q3REU2_AMAAE Unreviewed; 1444 AA.
AC A0A0Q3REU2;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=RUN and FYVE domain-containing protein 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=AAES_51951 {ECO:0000313|EMBL:KQK84105.1};
OS Amazona aestiva (Blue-fronted Amazon parrot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQK84105.1, ECO:0000313|Proteomes:UP000051836};
RN [1] {ECO:0000313|EMBL:KQK84105.1, ECO:0000313|Proteomes:UP000051836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQK84105.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQK84105.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LMAW01001214; KQK84105.1; -; Genomic_DNA.
DR STRING; 12930.A0A0Q3REU2; -.
DR Proteomes; UP000051836; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0017116; F:single-stranded DNA helicase activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd18041; DEXXQc_DNA2; 1.
DR CDD; cd15759; FYVE_RUFY2; 1.
DR CDD; cd17695; RUN_RUFY2; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR026851; Dna2/JHS1_DEXXQ-box.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR048459; DNA2_Rift.
DR InterPro; IPR014808; DNA_replication_fac_Dna2_N.
DR InterPro; IPR047333; FYVE_RUFY2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047335; RUFY1-3.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR047332; RUN_RUFY2.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45956:SF3; RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR45956; RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN; 1.
DR Pfam; PF13086; AAA_11; 2.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF08696; Dna2; 2.
DR Pfam; PF21123; Dna2_Rift; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000051836};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 875..1007
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 1378..1436
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT COILED 1058..1099
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1132..1373
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1444 AA; 163780 MW; 5016268F6EB202D2 CRC64;
MAERESVPVV PGDIIHLEGE CSSGTWVINE QSGYLVLYPD LLLSGTTISN SIRCMRRAVL
SERFRGSESG SRQTLVGTIL HEIFQQSVTN NLAQGKVEEL AKKIVYGQKY LKEMLLIVRI
EKSSGEKTED FSCTIEIVDI LDIEENIWSP RFGLKGKIDV TARVKIHREP GVQSRVILYT
LLNLERRVDP EAGFLLYLKT GTMYPVSGGR MDRRDVYKRQ VGNMIRVEEV QEISEGKYLH
FFQRGNGAIP GTNLLVGDRV VVSGEENGLL GLATGYVKEV SVTKVSCLLD RNLSKLPKNI
MFRLDHEEGN FGIGVTFENL SKLMNDSPVS ERLRNLIIDF HKPRFIQHLS SVLPPEAKET
VANILKGLNK PQKQAMKKVL LSKDYTLIVG MPGTGKTTTI CALVRILSAC GFSVLLTSFT
HTAVDNILLK LAKFKVGFLR LGRAQKVHPD IRKFTEEELF RSKSIKSVAD LEKFYNSQAV
VATSCMGVNH PVFVQRQFDF CIVDEASQIS QLICLGPLFC SKRFVLVGDH QQLPPLVLNA
EAKDLGMSES LFKRLEQNDN AVVQLTVQYR MNSKIMSLSN MLVYEGKLEC GSEKVSNATV
NLPNLIKLKL DLADASKTWL KNVLDPGTPV CFLNTEKIPA PEHAEKGGVS NMTEAKLVLF
LTSLFIKAGC NPSDIGIISP YRHQLKTITD LMAKLKENRV EVNTVDKYQG RDKSIIIVSF
VRNSKEENLG ALLKDWRRLN VAITRAKHKL IMVGCVPSLS YYPPLEKLLC HLQSEAMISF
FSVLFCERGQ FLNKERQAVY ARVVESEPDY YKCLMFKCIG SFFLIRGEGT NTLLSCAVLA
VKDPTAVERA NLLNMAKLSI KGLIESALSF GRTLDSDYPP LQQFFVVMEH CLKHGLKVRK
SFLSYNKTIW GPLELVEKLY PEAEEIAASV RDLPGLKTPL GRARAWLRLA LMQKKMADYL
RCLIIQRDLL SEFYEYHALM MEEEGAVIVG LLVGLNVIDA NLCVKGEDLD SQVGVIDFSV
YLKSDDDIGG KERDVQIAAI LDQKNYVEEL NRQLNSTVSS LHARVDSLEK SNTKLIEELA
IAKNNIIKLQ EENHQLRSEN TLILMKTQHH LEATKVDVEA ELQTYKHSRQ GLDEMYNEAR
RLLREESQLR QDMENELVVQ VSMKHEIELA MKLLEKDIHE KQDTLIGLRQ QLDEVKAINM
EMYQKLQVSE DAMKEKNEII GRLEDKTNQI NATMKQLEQR LQQAEKAQMD AEAEDEKLKQ
EYVNKSESLQ KEFSQKEKQL LQLETDLKIE KEWRQTLEDD LQKEKETVSH LKTETQEIIN
LKKEFLKLQE KNKQLRRICQ DQEAALQELA SKLSESKLKI EDIKEANKAL QGQVWLKDKE
ATHCKLCEKE FSLSKRKHHC RNCGEIFCNA CSDNELPLPS SPKPVRVCDS CHAILIQRCS
SNVP
//
