ID A0A0Q3T5X3_AMAAE Unreviewed; 880 AA.
AC A0A0Q3T5X3;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Desmocollin-2 {ECO:0000313|EMBL:KQK76134.1};
GN ORFNames=AAES_138697 {ECO:0000313|EMBL:KQK76134.1};
OS Amazona aestiva (Blue-fronted Amazon parrot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQK76134.1, ECO:0000313|Proteomes:UP000051836};
RN [1] {ECO:0000313|EMBL:KQK76134.1, ECO:0000313|Proteomes:UP000051836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQK76134.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of intercellular desmosome junctions. Involved in
CC the interaction of plaque proteins and intermediate filaments mediating
CC cell-cell adhesion. {ECO:0000256|RuleBase:RU004358}.
CC -!- SUBCELLULAR LOCATION: Cell junction, desmosome
CC {ECO:0000256|ARBA:ARBA00004568}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQK76134.1}.
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DR EMBL; LMAW01002880; KQK76134.1; -; Genomic_DNA.
DR STRING; 12930.A0A0Q3T5X3; -.
DR Proteomes; UP000051836; Unassembled WGS sequence.
DR GO; GO:0030057; C:desmosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 4.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR014868; Cadherin_pro_dom.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR InterPro; IPR009122; Desmosomal_cadherin.
DR PANTHER; PTHR24027:SF80; CADHERIN-13; 1.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 4.
DR Pfam; PF08758; Cadherin_pro; 1.
DR PRINTS; PR00205; CADHERIN.
DR PRINTS; PR01818; DESMOCADHERN.
DR PRINTS; PR01820; DESMOCOLLIN.
DR SMART; SM00112; CA; 5.
DR SMART; SM01055; Cadherin_pro; 1.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 1.
DR PROSITE; PS50268; CADHERIN_2; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000051836};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..880
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006207811"
FT TRANSMEM 679..702
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 135..232
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 233..344
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 345..461
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 462..567
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 880 AA; 97583 MW; BE4C533DB80CD484 CRC64;
MAPAAPRLVL GLLVLSLCCE ACKKVIXHVP SELEAETFVG RVDLKECLQS AEFISSSDGN
FKILEDGSVY TTSAVSLSAE KKTFTILLKD IQEQVEKKIH VSLVEEETKK TRHVRDTVLK
RTKRRWGPIP SVMIENSLGP FPLQIQQVQS DTAQNYTIYY SASGPGIDQD PKGLFYIERE
TGNIFATRAV DREQYPSFQI ICFATTPDGY SPEVPLVHTI RIEDDNDNAP YFTQDLFEFS
VPENSKPGVI VGKVTAEDRD ELYTLHTTLK YRIVSQNPPV TPAFSLHSDT GVIAVLLPQL
DRELVPSYTL LIEVRDMAGQ PFGLCTTGTA VIRIEDMNDN APCFKQMQYE TRVEENRVNV
EILRVSVVDL DEPGSPGSRA VYEIIKGNDD RSFEITTDKN TNEGILCVVK GLDYESAKQR
ILVIAVNNEA PYVLAPHSQQ LSQSTSSVTV HVLDVDEGPV FKPCLLRINV KECEDIGTTI
GRYVAEDPET GNSEGISYRI APGQCNWINI DEKSGEVRTV KVLDRDVGDM RRGQCNITVL
AVDRNGKTGT GTIQVFIVPG NKNYPRITKT EYIMCRDRKP ICLTAQDGDE SPYSTPFVYR
ITDRSLASMW KITRHNDNSV YLSPKGDIPF GTYDIPISVI DNGGKVGENR IKVNLCDCVT
PTECNGGKSR ELTGGNVTLG VWAILAMILG SLLLLLILIT LCGCCGSGVM HRHVTDDCAN
HNLIISNTEA PGEEVMDHNI IPLQNTCDQG GYGIKTGDQQ TFEMTKGRGH TLESVKGGGH
QTLGSVKEGG GQTMMDTCRY SYSEWHNFTH PRLGEKVHLC RQDEEQKHSE DYLLSYNYEG
KGSLAGSVGC CSDQHEEEAL DFLDQLEPKF RTLAETCVKR
//
