ID   A0A0Q3U5Z5_AMAAE        Unreviewed;       657 AA.
AC   A0A0Q3U5Z5;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Amiloride-sensitive sodium channel subunit gamma {ECO:0000313|EMBL:KQL61352.1};
GN   ORFNames=AAES_11887 {ECO:0000313|EMBL:KQL61352.1};
OS   Amazona aestiva (Blue-fronted Amazon parrot).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX   NCBI_TaxID=12930 {ECO:0000313|EMBL:KQL61352.1, ECO:0000313|Proteomes:UP000051836};
RN   [1] {ECO:0000313|EMBL:KQL61352.1, ECO:0000313|Proteomes:UP000051836}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FVVF132 {ECO:0000313|EMBL:KQL61352.1};
RA   Gilbert D.G.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Apical cell membrane
CC       {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004424}. Cell membrane
CC       {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. SCNN1G subfamily. {ECO:0000256|ARBA:ARBA00038067}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KQL61352.1}.
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DR   EMBL; LMAW01000001; KQL61352.1; -; Genomic_DNA.
DR   STRING; 12930.A0A0Q3U5Z5; -.
DR   Proteomes; UP000051836; Unassembled WGS sequence.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:InterPro.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR004724; ENaC_chordates.
DR   InterPro; IPR020903; ENaC_CS.
DR   NCBIfam; TIGR00859; ENaC; 1.
DR   PANTHER; PTHR11690:SF19; AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT GAMMA; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000313|EMBL:KQL61352.1};
KW   Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051836};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT   TRANSMEM        60..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          581..608
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          620..639
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        581..604
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   657 AA;  74641 MW;  6ECCD2918BA45749 CRC64;
     MTPSRAAXCT LSAXSSVQRT LPVRGPQAPT LSELMRWYCL NTNTHGCRRI VVSRGRLRRF
     LWILLTLSAV GLIIWQCAEL LMNYYSASVS VTVQFQKLPF PAVTICNINP YKYSAMKDYL
     SELDKETKKA LETFYGFSEG KSKVRRSVDE WNSSGSDFFQ QIPLLKFEDF SKTVTDFHSG
     QKRKIEGSVF HKDSSIVNSG DSNDIIGFQL CDANNSSECA LYTFSSGVNA IQEWYKLHYM
     NIMAQIPLET KEKLSYSADD LLLTCFFDGL SCDKRHFTLF HHPLHGNCYT FNSGENGTVL
     STSTGGSEYG LQVVLYIDEA DYNPFLVTST GAKIIVHDQN EYPFIEDIGT EIEPAAVTSI
     GMHFTQSRKL SKPYSDCTET GADIPVENLY NKSYSLQICL HSCFQKAMVD SCGCAQYAQP
     LPAGAEYCNY KKNPNWMYCY YKLHEKFVKE QLGCQQICKD ACSFKEWALT TSXAQWPSAV
     SEDWMLRVLS WDKGQKINKK LNKTDLVNLM VFYKDLNERF ISENPANTLV ILLSNFGGQL
     GLWMSCSVVC VIEIIEVFFI DSLSIVMRRQ WQXAKKWWNN RQRERSGKPP QAGDLERQGH
     DNPVCIDEDL PTFNTALRLP LPQESPLPRT PPPNYSTLRL ETAFTEQLPD TLELGQH
//