ID A0A0Q3UPY9_AMAAE Unreviewed; 1117 AA.
AC A0A0Q3UPY9;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN ORFNames=AAES_165197 {ECO:0000313|EMBL:KQK73650.1};
OS Amazona aestiva (Blue-fronted Amazon parrot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQK73650.1, ECO:0000313|Proteomes:UP000051836};
RN [1] {ECO:0000313|EMBL:KQK73650.1, ECO:0000313|Proteomes:UP000051836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQK73650.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQK73650.1}.
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DR EMBL; LMAW01003169; KQK73650.1; -; Genomic_DNA.
DR STRING; 12930.A0A0Q3UPY9; -.
DR Proteomes; UP000051836; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR CDD; cd02665; Peptidase_C19I; 1.
DR CDD; cd14354; UBA_UBP25; 1.
DR CDD; cd20486; USP25_C; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR044635; UBP14-like.
DR InterPro; IPR003903; UIM_dom.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR43982; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR43982:SF6; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2-RELATED; 1.
DR Pfam; PF00443; UCH; 1.
DR SMART; SM00726; UIM; 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50330; UIM; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000313|EMBL:KQK73650.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000051836}.
FT DOMAIN 169..651
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 469..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 680..707
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 478..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1117 AA; 128350 MW; 2FFE07B57EF1A837 CRC64;
MTVEQNVLQP GGAAKHQQTF LNQLREITGI NDIQVLQQAL KDSNGNLELA VAFLTAKNAK
VPQLEEATYY QTALPGNDRY ISVGSQADTN VIDLTGDDKD DLQRAIALSL EESNRAFRET
GITDEEQAIS RVLEASIAEN KASLKRTHPE VWSDSPNPYD RKRQDNCPVG LKNVGNTCWF
SAVIQSLFNL LEFRRLVLNF NPPANAQDLP RNQKEHRNLP FMRELRYLFA LLVGSKRKYV
DPSRAVEILK DAFKSNDSQQ QDVSEFTHKL LDWLEDAFQI KAEEERDGEK SKNPMVELFY
GRFLAVGVLE GKKFENTEMF GQYPLQVNGF KDLHECLEAA MIEGEIESLH SENSAKSGQE
HWFTELPPVL TFELSRFEFN QALGRPEKIH NKLEFPPILY LDRYMHKNRE XTRIKRDEIK
RLKEYLTVLX QRLERYLSYG SGPKRFPLVD VLQYALEFAS SKPVCTSPVD DLGATAPASS
TLPAQTSPST IEQQGPSSSD VPSTSPVQRS VIHKPFTQSR IPPDLPMHPA PRHITEEELS
VLEGCLHRWR TEVENDTRDL QESISRIHRT IELMYSDKTM VQVPYRLHAV LVHEGQANAG
HYWAYIYDHH QNRWMKYNDI SVTKSTWEEL ERDSFGGYRN ASAYCLMYIN XKEQYLIQEE
FNKETGQILV GMDTLPSDLR DYVKEDNKRF EKXLEEWDAE LAQKAQQEKL LSQIPRAPAP
SPAPVQAGEP EYLEQPSRTD ISKHLKEDSV QAINKALAEQ EDRGPEAIMD TTADNAPAQP
APNQRVVEVA IPDVGTFVIE SEEGGYDDEV MLTPNMQGII MAIGKARNVY DRCGPEAGFF
KAIKLEYTRL LKLAQEDPPP ECDYRLRHAI VYFIQNQAPK KIIERTLLEQ FGDHNLSFDE
RCRNIMKVAQ AKLEMIKPDE INMEEYERWH QDYRNFRETT MFLXVGLEFF QKKSYMEALL
YLIYAYQNNK ELLSKGPYRG HDEELISHYR RECLLKLNEH AAALFESGDD QEVNNGXIIM
NELIVPCLPL LLVDEMEEKD IVAVEDMRNR WCSYLGQEME PNLQEKLTDF LPKLLDCSTE
IKGFNDPPKL PSYSTHELCE RYARIMLSLS RTPADGR
//
