ID A0A0Q3US64_AMAAE Unreviewed; 1200 AA.
AC A0A0Q3US64;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 22-FEB-2023, entry version 20.
DE SubName: Full=Insulin receptor substrate 1 {ECO:0000313|EMBL:KQK80450.1};
GN ORFNames=AAES_92931 {ECO:0000313|EMBL:KQK80450.1};
OS Amazona aestiva (Blue-fronted Amazon parrot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQK80450.1, ECO:0000313|Proteomes:UP000051836};
RN [1] {ECO:0000313|EMBL:KQK80450.1, ECO:0000313|Proteomes:UP000051836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQK80450.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQK80450.1}.
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DR EMBL; LMAW01002527; KQK80450.1; -; Genomic_DNA.
DR STRING; 12930.A0A0Q3US64; -.
DR Proteomes; UP000051836; Unassembled WGS sequence.
DR GO; GO:0005158; F:insulin receptor binding; IEA:InterPro.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:InterPro.
DR CDD; cd01257; PH_IRS; 1.
DR CDD; cd01204; PTB_IRS; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR039011; IRS.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10614; INSULIN RECEPTOR SUBSTRATE; 1.
DR PANTHER; PTHR10614:SF11; INSULIN RECEPTOR SUBSTRATE 1; 1.
DR Pfam; PF02174; IRS; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00628; INSULINRSI.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Receptor {ECO:0000313|EMBL:KQK80450.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000051836}.
FT DOMAIN 14..116
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 161..265
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 119..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 762..870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 982..1097
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1109..1200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..133
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..809
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1200 AA; 126266 MW; F7666FC3DF5E19F2 CRC64;
MASPTDNNEG FFSDVRKVGY LRKPKSMHKR FFVLRAASES GPARLEYYEN EKKWRHKSGA
PKRSIPLESC FNINKRADSK NKHLVALYTK DEHFAIAADS EPEQESWYQA LLQLHNRAKG
HHHLHHHHHH HHSDITFGGS SAGLGEAAED SYGXVAPGPA FKEVWQVILK PKGLGQTKNL
IGIYRLCLTN KTISFVKLNS DAAAVVLQLL NIRRCGHSEN FFFIEVGRSA VTGPGEXWMQ
VDDSVVAQNM HETILEAMRA MSEEFRPRSK SQSSSNCSNP ISVPLRSRHH VNNPPPSQVG
LSRRSRTESV TATSPAGGGG TGGKPSSFRV RASSDGEGTM SRPASVDGSP VSPSANRTHS
HRHRGNSRLH PPLNHSRSIP MPSSRCSPSA TSPVSLSSSS TSGHGSTSDC LFPRRSSASV
SGSPSDGGFI SSDEYGSSPC DFRSSFRSVT PDSLGHTPPA RGDEELNYIC MGGKATSSCC
SLAAPNGHFI PRTCHVQQQP RYPSTPCCPR GGSEEVADLE KAFRKRTHSA GTSPTISHQK
TPSQSSVASI EEYTEMLPSY PCGSSRLPSY RHSAFVPTHS YPEECLEMHH LDSSHHRTNS
APHTDDGYMP MSPGVAPVPS GGGAPKGGDY MPMSPKSVSA PQQIINPGRG GRHPPATVDS
NGYMMMSPSG SYSPESGSAG YGKIWANGTS HHPKLSVESN EGKLPCGGSD YINMSPASGS
TTSTPPDCYF GGVGQPAAED IAATANHKPI YSYFSLPRSF KHVHRRGGSG PAVASEEGSP
QPRIALGSGR LLYAAEDSSS STSSDSLGGG GGGTEGGLPL QAQPPRKVDT AVQTKGRLAR
PTRLSLGGPK ASTLPRAREQ PPLLLPPEPK SPGEYVNIEF VAVDKPAFPS AVLGLGLPPP
PGSEAAEEYM NMELGPPRAP CTSGFAAARA APAARPGRGA APGGRDYVIM QMGGAAAGGS
CSDCTDSPSP CSPARLLSYA DVRAGRPAAE KPPPAAASTA SPELPRPPAE LSAAPPRSSS
LLGGPGAGSA FTRVSLSPGR NQSAKVIRAD PQGGRRRHSS ETFSSTPSAA RGAVGGGGLG
APFPCGGAGG AEEVKRHSSA SFENVWLRPA AGEAAGAPAT RREPGPAPAL ENGLNYIDLD
LVKDSSHRRH HLHHPTEGAA LPGGKQLPPP KPPGQPRGGG HSSDDLSAYA SISFQKREEV
//
