ID A0A0Q3UTN1_AMAAE Unreviewed; 618 AA.
AC A0A0Q3UTN1;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=heparosan-N-sulfate-glucuronate 5-epimerase {ECO:0000256|ARBA:ARBA00012087};
DE EC=5.1.3.17 {ECO:0000256|ARBA:ARBA00012087};
GN ORFNames=AAES_45951 {ECO:0000313|EMBL:KQK84762.1};
OS Amazona aestiva (Blue-fronted Amazon parrot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQK84762.1, ECO:0000313|Proteomes:UP000051836};
RN [1] {ECO:0000313|EMBL:KQK84762.1, ECO:0000313|Proteomes:UP000051836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQK84762.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[heparosan-N-sulfate](n) = [heparan-N-sulfate](n);
CC Xref=Rhea:RHEA:20197, Rhea:RHEA-COMP:9556, Rhea:RHEA-COMP:9557,
CC ChEBI:CHEBI:58041, ChEBI:CHEBI:58287; EC=5.1.3.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000434};
CC -!- PATHWAY: Glycan metabolism; heparin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004841}.
CC -!- SIMILARITY: Belongs to the D-glucuronyl C5-epimerase family.
CC {ECO:0000256|ARBA:ARBA00005584}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQK84762.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LMAW01000980; KQK84762.1; -; Genomic_DNA.
DR STRING; 12930.A0A0Q3UTN1; -.
DR UniPathway; UPA00862; -.
DR Proteomes; UP000051836; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0047464; F:heparosan-N-sulfate-glucuronate 5-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:InterPro.
DR GO; GO:0030210; P:heparin biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR010598; C5-epim_C.
DR InterPro; IPR039721; C5-epimerase.
DR PANTHER; PTHR13174; D-GLUCURONYL C5-EPIMERASE; 1.
DR PANTHER; PTHR13174:SF3; D-GLUCURONYL C5-EPIMERASE; 1.
DR Pfam; PF06662; C5-epim_C; 1.
DR Pfam; PF21174; Glce_b_sandwich; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000051836};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 417..608
FT /note="D-glucuronyl C5-epimerase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06662"
FT REGION 55..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..85
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 618 AA; 70122 MW; 7564E1E01789D48E CRC64;
MRTLCIHHLV ERYGVNMRCL AARVNYKTLI IIXALFTLVM VLLWNRCSSD RAGPFPRSLS
GPERRAAASE SDLARQQSEE ASPQEQQKAP PIAGAFNKAP GLKYEEIDCL INDEHTVKGR
REGNEVFLPF SWVEKYFEVY GKIAQYDGYD RFEFSHSYSK VYTQRAPYHP DGVFMSFEGY
NVEVRDRVKC ISGVEGVPLS TQWGPQGYFY PIQIAQYGLS HYSKNLTEKP PHVEVYETAE
EKDRASRSAE WTVPKGCSLS TVSDRAKFTS VKQFIAPDNT EGISLQLGNT RDFIISFDLK
FITNGSVSVV LETTEKNQLF TVHYVSNNQL XAFKDRDIYY GIGPRTSWST LTRDLVTDLR
KGVGLSNTKA VKQTKIMPKR VVRLVAKGRG FLDNVTISAT AHMAAFFAAS NWLVRNQDER
GGWPIMVTRK LGEGFKSLDP GWYSAMAQGQ AISTLVRAYL LTKDHAFLSS ALRATAPYKL
PSEQRGVKAV FMNRHDWYEE YPTSPSSFVL NGFMYSLIGL YDLKETAGEK LGKEARVLYE
RGMESLKAML PLYDTGSGTI YDLRHFMLGT APNLARWDYH TTHINQLQLL STIDESPLFK
EFVKRWKSYL RGGRAKHN
//
