ID A0A0Q3WGX1_BRECH Unreviewed; 847 AA.
AC A0A0Q3WGX1;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=AN963_24400 {ECO:0000313|EMBL:KQL44538.1};
OS Brevibacillus choshinensis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Brevibacillus.
OX NCBI_TaxID=54911 {ECO:0000313|EMBL:KQL44538.1, ECO:0000313|Proteomes:UP000051063};
RN [1] {ECO:0000313|EMBL:KQL44538.1, ECO:0000313|Proteomes:UP000051063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 8552 {ECO:0000313|EMBL:KQL44538.1,
RC ECO:0000313|Proteomes:UP000051063};
RA Liu B., Wang J., Zhu Y., Liu G., Chen Q., Chen Z., Lan J., Che J., Ge C.,
RA Shi H., Pan Z., Liu X.;
RT "Genome sequencing project for genomic taxonomy and phylogenomics of
RT Bacillus-like bacteria.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQL44538.1}.
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DR EMBL; LJJB01000013; KQL44538.1; -; Genomic_DNA.
DR RefSeq; WP_055747124.1; NZ_LJJB01000013.1.
DR AlphaFoldDB; A0A0Q3WGX1; -.
DR STRING; 54911.AN963_24400; -.
DR PATRIC; fig|54911.3.peg.2939; -.
DR OrthoDB; 9806486at2; -.
DR Proteomes; UP000051063; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR InterPro; IPR005741; TopoIV_A_Gpos.
DR NCBIfam; TIGR01061; parC_Gpos; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR PANTHER; PTHR43493:SF9; DNA TOPOISOMERASE 4 SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 5.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 9..468
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT REGION 807..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 433..467
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 819..837
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 847 AA; 94144 MW; 2B8D16D44DFB09FA CRC64;
MLSNQIIEQS FAEIMGKRFG DYANLVILSR AIPDARDGLK PVQRRILYAM YEEGNTNDKP
YRKSAKTVGF VMGTYHPHGD SAIYETMVRM AQWWKMRHVL IQGHGNFGSL DADPPAAMRY
TESRLSALAN EMTRDIEKDT VTFIPNYDNS AQQPAVLPSR FPNLLVNGAS GIAVGFATDI
PTHNLAEIID AAVAQMKKPS ITLDELMEYV KGPDFPTGAI VQGVSGIKKA FETGRGQFII
RAKTHIEEAK GGKLKKIVVS EIPHEVVKSK LVAQIDELVM ERKIEGALAV RDETGRKEAE
LKKVRIVIDL RKEADEQAIL NYLYKNTDLQ IYYNYNMNVI HEGTIRQMGL KALLGAYIDH
QKEVVTRRSQ YDLDKKQHRE HIVQGLIRAK SILREIVDTI MDSEDRADAK RNIMEKYGFT
DLQADAILAI QLASLTRLDI VKLEKELASL AKEIEELQSI LASEKKLIQV ITGELNEIKK
KYSEPRLTEI QGEIEEIKID IAMQINAEDC IVTLTNEGYI KRTSPRSFKS VGGTLETCGV
KEGDKVRHFV ETNTSHTALF FTQDGKYFAT LVNSFPDDKW KDIGSAIVNV IPLEKQQKIV
GFTIVESFKQ PSYVYHVSRH GLIKKTALSE YETNRSGALV AAKLKSEDDE FVTAFVVDEE
GGILGATRDG MGIRFQRSEV SPTGRASSGV KAIALSSGDE VIMMMPVATD DTRSFSLLTT
EGVVKRTAIS DIPLQGRAGK GVQLIRKRKN NPHQLIALSI EETMYAWTSQ NEWSLVSTDQ
VIVNEQGGIG RSVVEGGAKA VAFETVLPTE EAKEDQAKGS GEGSSSPQRS SETPFNLFDG
ISAEEKE
//
