ID A0A0Q3WZF3_9BACI Unreviewed; 862 AA.
AC A0A0Q3WZF3;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=AN964_14330 {ECO:0000313|EMBL:KQL54555.1};
OS Heyndrickxia shackletonii.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Heyndrickxia.
OX NCBI_TaxID=157838 {ECO:0000313|EMBL:KQL54555.1, ECO:0000313|Proteomes:UP000051888};
RN [1] {ECO:0000313|EMBL:KQL54555.1, ECO:0000313|Proteomes:UP000051888}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 18435 {ECO:0000313|EMBL:KQL54555.1,
RC ECO:0000313|Proteomes:UP000051888};
RA Liu B., Wang J., Zhu Y., Liu G., Chen Q., Chen Z., Lan J., Che J., Ge C.,
RA Shi H., Pan Z., Liu X.;
RT "Genome sequencing project for genomic taxonomy and phylogenomics of
RT Bacillus-like bacteria.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQL54555.1}.
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DR EMBL; LJJC01000004; KQL54555.1; -; Genomic_DNA.
DR RefSeq; WP_055740333.1; NZ_LJJC01000004.1.
DR AlphaFoldDB; A0A0Q3WZF3; -.
DR STRING; 157838.AN964_14330; -.
DR PATRIC; fig|157838.3.peg.3189; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000051888; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000051888}.
FT DOMAIN 681..697
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 607..614
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 862 AA; 99149 MW; 9050EBF69252B914 CRC64;
MSQYTPMILQ YLQVKADYQD AFLFFRLGDF YEMFFEDAIK ASQELEITLT SRDGGSTERI
PMCGVPYHSA ANYIEQLVEK GYKVAICEQV EDPKTAKGVV KREVVQLITP GTMMEGKGIA
EKENNFIASI TSFDDRSFGL AYTDLSTGEG HVTFIDSDFE QVVNELSILG VKEVVVSEIF
DDLFIKQLKE RNHITISFEN DTEIKTEFAR IIADIESGEL KQTVIRLLNY LHRTQKRSLD
HLQPITTVDL HQFMKIDYYS KRNLELTETI RSKGKKGSLL WLLDETMTSM GGRRLKNWID
RPLIDSRAIE KRHLLVEIFM EHFFERQELR ERLKEVYDLE RLAGRVAFGN VNARDLIQLK
HSLQQVPAIH AIMEQFHHEE ALKLSNSLDP CEELTDLLER SILENPPISV KEGGIIQNGF
NAELDQYRDA SRNGKTWLAR LEQEERNRTG IKSLKIGYNR VFGYYIEVTK SNLHLLEEGR
YERKQTLTNA ERFITPELKE KEALILQAEE KSTELEYELF LQIRESVKEF IPRLQRLAQI
ISEIDVLQCF ASVSEKRHYV KPIFNKERKI VIKDGRHPVV EKVMDAQEYV PNDCYMDKER
EMLLITGPNM SGKSTFMRQI ALTSILAQIG CFVPASQAIL PVFDQVFTRI GAADDLISGQ
STFMVEMLEA RNAIMNATQN SLILFDEIGR GTSTYDGMAL AQAIIEYIHD RIGAKTLFST
HYHELTVLEE NLEQLKNIHV SAMEQNGKVV FLHKIKEGPA DKSYGIHVAE LAELPHELIV
RANEILAELE ENSDQVKETP KMKEETVQAQ LSFFEEPNTK VKQETSSKDK KILEELKSIN
LLEMNPLQAM NVLYELQKKI KS
//
