ID A0A0Q3XAK5_AMAAE Unreviewed; 1639 AA.
AC A0A0Q3XAK5;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=AAES_03745 {ECO:0000313|EMBL:KQL60890.1};
OS Amazona aestiva (Blue-fronted Amazon parrot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQL60890.1, ECO:0000313|Proteomes:UP000051836};
RN [1] {ECO:0000313|EMBL:KQL60890.1, ECO:0000313|Proteomes:UP000051836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQL60890.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQL60890.1}.
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DR EMBL; LMAW01000075; KQL60890.1; -; Genomic_DNA.
DR STRING; 12930.A0A0Q3XAK5; -.
DR Proteomes; UP000051836; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd18017; DEXHc_RecQ3; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR CDD; cd07977; TFIIE_beta_winged_helix; 1.
DR CDD; cd06141; WRN_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR029491; Helicase_HTH.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR040501; TFA2_Winged_2.
DR InterPro; IPR003166; TFIIE_bsu_DNA-bd.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR PANTHER; PTHR13710:SF120; WERNER SYNDROME ATP-DEPENDENT HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF14493; HTH_40; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR Pfam; PF18121; TFA2_Winged_2; 1.
DR Pfam; PF02186; TFIIE_beta; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
DR PROSITE; PS51351; TFIIE_BETA_C; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:KQL60890.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000051836}.
FT DOMAIN 436..602
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 627..779
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1031..1110
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT DOMAIN 1413..1493
FT /note="TFIIE beta"
FT /evidence="ECO:0000259|PROSITE:PS51351"
FT REGION 943..978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1290..1343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1365..1410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1586..1624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1378..1392
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1393..1410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1602..1620
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1639 AA; 182904 MW; 93AEC4CD10547508 CRC64;
MLTQSQEEVL SDKKKSAFQR SVLEDGLPFL EFRGSVVYSY EVSDCSLLSE DIRQSLSHGA
AVGFDIEWPP SYTKGKIAKI AVIQICVSEE XCYLFHISSM SGFPKGLKRL LEDETIKKVG
VGVEGDQWKL MSDFEIKLKS FVELADVANE KLRCKEIWSL NGLVKHLFGK QLLKDKSVRC
SNWKEFPLNE EQKLYAATDA YAGFIIYEKL KNMNNSDQKV LCGTRDDMCV KERLTSLAAE
IIELASCIPD SSGQPENVQR AAEIIADISE NVTALRSMLL GSGCPSVLEK SSGRSPTNLE
AESANVEAQK VEMPELAKQL EGDFSICSDA TLAGFWEEHI KEETERGSDV EDGAATASSQ
DKVYREDFMS LDITEQELQI LEGQAAEEFA KEAAAEEEEE ECLDPLLPLP SERHITCLKT
YFGHSSFKPV QWKVINSLLE DRRDNLVVMA TGYGKSLCYQ FPPVYTGLIG IVICPLISLM
EDQVLQLIMS DIPACLLGSA QSKNIKECIK GGQYRVIYMT PEFCSVNLDL LQELDQTIGI
TLIAVDEAHC ISEWGHDFRN SFRTLGSLKK ALPSVPIVAL TATASPSIRE DIVNCLKLKN
PQVTCTSFDR PNLYLEVGQQ SGNILRDLKQ FLIRKGSSSI YEFEGPTIIY CPSRKATEQV
VSELMKLSVA XRAYHAGMGI KQRREAHHQF MRDEIQCVVA TVAFGMGINK ADIRMVIHYG
APKEMESYYQ EIGRAGRDGL PAACHVLWTA SDLAFNRHLL SEIRNENFRL YKLKMLGKIG
KYLVSNSCRR KIILSHFEDK QLXKVSSGIM GTEDCCDNCR SRASCFAVPS DFEGGLQDFG
KQAYQLLSAV STLEGKFGTR VPILFLRGSS SQRLPNRYRS HPLFGSGKEW PENWWKLLCQ
QLIMEGFLKE VSKXNTFATM CMLTQKGRNW LLKAGSDSNP SLLLHSSEDL NLQRPPRSTR
PLPVPSTQRS PAKKGAGQSP VKQMSLYEMF AYERKGKTLP GSSNVLNSVA ECSLVRSPLK
PSEPVVSSRE KELETALYGK LLTARQKVAN EKVIPPAVLA TNKILVDMAR IRPTTVENVK
RIDGVSEAKS TMLIPLLAEI KDFCQVNGLQ TDTFSPSGSK DQEKASXXKC XRALSPSEHV
TYVLFQEKNL SVRTISESRS LPLSEVGTHL FQALQAGYPV NLERAGLTPE VHQLISDIIR
NPPIESDTTK IQAIRKLVPA NIELYLIRMT IALLDKGDRN KSWDGSGFKR MLVWSEKQEE
KTGADQENRE DAMWSKTKLA FFLSYGKSAQ SVDGGQPGGG GAAGGCPKPV TPVAPNEPAL
DPSEEEPFAD SESKVGIIPT KELQQSRIMD PTLLRERELF KKRALSTPVV EKRPAPSSDS
SSSKKKKAKV EQSGSSSSKQ NTDHSNGSFN FKSLSGGSGY KFGVLAKIVN YMKTRHQRGD
THPLTLEEIL DETQHLDIGL KQKQWLMSEA LVNNPKIEVV DGKYAFKPKY NLKDKKALLR
LLDKHDQRGL GGILLEDIEE GLPXAQKAIK ALGDQIIFVN RPDKKKILFY NDKSCQFTVD
EEFQKLWRSI PVDSMDEEKI EEYLKRQGIS SMQETGPKKI APIQRRKKPA SQKKRRFKSH
NDHLAGVLKD YSDVVPGKQ
//
