ID A0A0Q4BLD3_9SPHN Unreviewed; 396 AA.
AC A0A0Q4BLD3;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:KQM13801.1};
DE EC=2.3.1.9 {ECO:0000313|EMBL:KQM13801.1};
GN ORFNames=ASE49_12140 {ECO:0000313|EMBL:KQM13801.1};
OS Novosphingobium sp. Leaf2.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=1735670 {ECO:0000313|EMBL:KQM13801.1, ECO:0000313|Proteomes:UP000050893};
RN [1] {ECO:0000313|EMBL:KQM13801.1, ECO:0000313|Proteomes:UP000050893}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf2 {ECO:0000313|EMBL:KQM13801.1,
RC ECO:0000313|Proteomes:UP000050893};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQM13801.1, ECO:0000313|Proteomes:UP000050893}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf2 {ECO:0000313|EMBL:KQM13801.1,
RC ECO:0000313|Proteomes:UP000050893};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQM13801.1}.
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DR EMBL; LMJY01000020; KQM13801.1; -; Genomic_DNA.
DR RefSeq; WP_056774652.1; NZ_LMJY01000020.1.
DR AlphaFoldDB; A0A0Q4BLD3; -.
DR STRING; 1735670.ASE49_12140; -.
DR OrthoDB; 7181944at2; -.
DR Proteomes; UP000050893; Unassembled WGS sequence.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR18919:SF153; TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00098; THIOLASE_1; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:KQM13801.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000050893};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:KQM13801.1}.
FT DOMAIN 4..260
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 269..390
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 89
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 348
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 378
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 396 AA; 41141 MW; 712864E43A6AF296 CRC64;
MEDIYIVGGV RTAVGDFGGS LKGFMPAELG TLVAVEALKR AGVEPEAVEH VVIGQVMPTS
ARDQMLARVI GINAGVPVAT PALTLNRLCG SGVQSIISSA QMMKLGEASI TLAGGAESMS
NVPYHDHGVR WGRKMGANTQ EDALTLGLSD AIGGYHMGIT AENMAERYGI TREAMDALSV
TSHQRAAHAI AEGRFKDQIL PVEVKTRKGV TVFDTDEHVK ADTTMDVLAK MRPAFKKDGS
VTAGNASGIN DGAAAVVLAT GTEVEKRGLK PLARIVAWGH AGVEPEYMGE GPIQAVPIAL
KRAGLALDQI DVIESNEAFA AQACAVINAL GLDPDKVNPN GSGVSIGHPV GATGTMLTVK
CAYELQRIGG RYGLITMCIG GGQGIALIIE NVEHAA
//
