ID A0A0Q4CTQ9_9SPHN Unreviewed; 505 AA.
AC A0A0Q4CTQ9;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:KQM28823.1};
GN ORFNames=ASE58_02895 {ECO:0000313|EMBL:KQM28823.1};
OS Sphingomonas sp. Leaf9.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=1735674 {ECO:0000313|EMBL:KQM28823.1, ECO:0000313|Proteomes:UP000051210};
RN [1] {ECO:0000313|EMBL:KQM28823.1, ECO:0000313|Proteomes:UP000051210}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf9 {ECO:0000313|EMBL:KQM28823.1,
RC ECO:0000313|Proteomes:UP000051210};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQM28823.1, ECO:0000313|Proteomes:UP000051210}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf9 {ECO:0000313|EMBL:KQM28823.1,
RC ECO:0000313|Proteomes:UP000051210};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQM28823.1}.
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DR EMBL; LMKC01000001; KQM28823.1; -; Genomic_DNA.
DR RefSeq; WP_055817688.1; NZ_LMKC01000001.1.
DR AlphaFoldDB; A0A0Q4CTQ9; -.
DR OrthoDB; 462203at2; -.
DR Proteomes; UP000051210; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR PRINTS; PR00368; FADPNR.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 77
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 12..15
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 77
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 333
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 342
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 505 AA; 55783 MW; 316612AD603A683C CRC64;
MTPLKRILIA GGGSAGWMTA AMFARLFKGR YAITLIESDA IGTVGVGEAT IPAIKKFNDL
LGLDEDDFLR RTQGSFKLGI RFDDWSRIGS SYVHGFGVIG RDLEWLRCHQ YWTKLHRAGA
GGPLDDYSIN TVAATANRFL RPRADMPDSP IGQIAYAFHF DAGLYAAYLA DYARARGVER
REGEIVAVGQ HPDTGFLSSV TLADGAVIQA DLFIDCSGFR GLLIEQTLST GYESWSHWLP
CDRAVAVASE RSADFPPYTC STARPAGWQW RIPLQHRTGN GHVYASRHMD DATAEALLLD
HLEEPAVGTP RRLSFVPGKR RKGWVRNCVA IGLSAGFLEP LESTGLHLIQ SAILRLVRLM
PDAGFDPATI AEYNRQTDFE MERIRDFIIL HYKATTRDDT PFWRHVRTMD VPETLARKMA
LFAANGRIFR EDDELFAEES WIQVLIGQGI VPAAPDPLVD VTPAAEIERY LADVRGVIAK
CVARMPAHDA FVAHHCAAPS PTGTA
//
