ID A0A0Q4FZN4_9SPHN Unreviewed; 1142 AA.
AC A0A0Q4FZN4;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=ASE72_14330 {ECO:0000313|EMBL:KQM70579.1};
OS Sphingomonas sp. Leaf20.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=1735685 {ECO:0000313|EMBL:KQM70579.1, ECO:0000313|Proteomes:UP000051642};
RN [1] {ECO:0000313|Proteomes:UP000051642}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf20 {ECO:0000313|Proteomes:UP000051642};
RA Garrido-Oter R., Mueller D.B.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000051642}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf20 {ECO:0000313|Proteomes:UP000051642};
RA Vorholt J.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQM70579.1}.
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DR EMBL; LMKN01000009; KQM70579.1; -; Genomic_DNA.
DR RefSeq; WP_056023008.1; NZ_LMKN01000009.1.
DR AlphaFoldDB; A0A0Q4FZN4; -.
DR STRING; 1735685.ASE72_14330; -.
DR Proteomes; UP000051642; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014151; DNA_helicase_AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02784; addA_alphas; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000051642}.
FT DOMAIN 11..496
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 504..787
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 936..969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1142 AA; 122236 MW; A096EC45A0084D3F CRC64;
MDVSSGELRT LPRLKGAQAA ASDPASHVWL SASAGTGKTQ VLAARVFRLL LRGVDPGAIL
CLTFTKAGAA EMAQRINGRL AAWVRMPGPA LFQDLQALGE EGGPAQQDYA RTLFAKVLDA
PGGGLRIQTI HGFCQGLLAA FPVEAGLTPG FRPLEAREEA GLAREALAGM LADAERNGRE
RPVEIVGRLS LRLGEGGAEA FLMACARALP ALETMPSGVQ PWLRRTLELP SGDIGEAVAE
WCDALDIDAI TRIAAANAAW GTATGLKQAA TIEAWLASPD RAGTLGDLAG VVLTGKGELR
KVQKKLLDIE PDYEVLAQHI GAACTDIVSM TQRVGYADLL ADGLEIGRDY ARAYALAKRR
VGGVDFDDLI ATTVALLDQP GIGEWVRYKL DQATEHVLID EAQDTNADQW RIVRALADEF
FVGRGIYAPS TRTLFTVGDW KQAIFGFQGT DPFNFAAAEM HFGRRAKEVA GDDDWPEDER
GLPLERLSLT HSFRSTRPVL EFVDAAVAAT GEPGLGAIGD LDVHASEVRG PGSVTLWPPV
VAGGNEDDEE GWIDDAVRKL AGDIARAVKS WLAPDGLMLD SKGRRLRPED VMILVKRRGD
LASLIVARLY AEGVPVAGVD RLRLNAPLAV QDLLATIRFV LQPEDDLSLA ALLVSPLIGW
TQDELMQAAP REAGPLWRHL QRTQPAARLA PLLAMLARAD IATPYQFLEE LLSGPLDGRR
KLIRRLGTEA RDPIEELLNA ALNFESTTTP SLQRFLDWFD RGDVDIVRDP SAPLDAVRVM
TAHGAKGLQA PLVILADATA DPAAAPRSIL KWTPEDLPAP LPVFRPRSSE RGGPLDAVVS
AAERRELEEH WRLFYVAATR AEERLVIAGA LGTRAKGVAP ATSWYAAAER ALTALDIPEA
EGERCFTGTS VDAPVIAKDD RHARPATPVP LPEWARVAAP REARPSRPLS PSALGEDAVS
DPPPTPAMRA AAERGSLIHK LLERLPAVAA DARAGAADRW LAQAGGVADA DVRAEIAASA
IGVIADPRFT ALFGPESLAE APIAATLADG VVVSGTVDRL LIGADVVRVI DFKTGRRAPR
DVAEVPDYHL RQMAAYAAAL RVIFPGRRVE AALLYTAGPR LIAVPEDTLV RHKPGYAATE
QS
//
