ID A0A0Q4G447_9BURK Unreviewed; 2057 AA.
AC A0A0Q4G447;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Alpha-2-macroglobulin {ECO:0000313|EMBL:KQM68352.1};
GN ORFNames=ASE76_15085 {ECO:0000313|EMBL:KQM68352.1};
OS Xylophilus sp. Leaf220.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales; Xylophilus.
OX NCBI_TaxID=1735686 {ECO:0000313|EMBL:KQM68352.1, ECO:0000313|Proteomes:UP000051325};
RN [1] {ECO:0000313|EMBL:KQM68352.1, ECO:0000313|Proteomes:UP000051325}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf220 {ECO:0000313|EMBL:KQM68352.1,
RC ECO:0000313|Proteomes:UP000051325};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQM68352.1, ECO:0000313|Proteomes:UP000051325}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf220 {ECO:0000313|EMBL:KQM68352.1,
RC ECO:0000313|Proteomes:UP000051325};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQM68352.1}.
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DR EMBL; LMKO01000028; KQM68352.1; -; Genomic_DNA.
DR RefSeq; WP_055843506.1; NZ_LMKO01000028.1.
DR STRING; 1735686.ASE76_15085; -.
DR OrthoDB; 9767116at2; -.
DR Proteomes; UP000051325; Unassembled WGS sequence.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF11974; bMG3; 1.
DR Pfam; PF01835; MG2; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000051325};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..2057
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006218349"
FT DOMAIN 1073..1256
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 1314..1404
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT REGION 292..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 853..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1856..1890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1863..1890
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2057 AA; 219703 MW; 31F15FAC23B11F48 CRC64;
MTIHRPALAA LVAAAALGAV PAAHALQVSS FSPQGEVARI RQAVAKFDGP AVRFGDPAAP
APLALRCSDA EAGKGTGRWT SDREWVFDFA RDLPPGVSCT VQPVTAFKSA SGQPLAPTTS
YKFNSGGPIV VNTRPGSYQP IDEEQFFVLQ LNGAATAASV QQNVWCAVDG LGERVPVRAI
EGAQRAAVLK ATGLAERAGK EPLAFPTLAC NRTLPPGGKV SIVFGQGVST PSGVANTVEK
RFTWTVREPF SAEFSCSREN AQAACLPIRP MSLRFNAPVT RQQAGAIRLR GGSQAGTPVF
EGDEARPAGQ KAPDPDSVVN ALRFTGPFDE SATYTLELPA GFKDASGRTL RNAGSFPLQA
RTGALPPLAK FAAAPFGVVE RFAEPDGEKT GKGMLPVTLR KVEPGLPVKT LAPGAAAPPA
GTVSDLRPQG DAEIIRWMKL LQRYDDGSVQ RSQAQRDVRG PLPPALPQEG SKRLSDRVET
RSVSLLGGQA GVKTLDLPYA EGNDPRPFEV VGIPLDPGFH VVEIASQRLG EALLDDRYGP
QRPMFVRTGA LVTNLGVHFK LGRENAAVWV TSLDKGLPVA GAAVRVSDCT GKELAAATTD
ADGLARIEGL SPEAPRCAGE NDWDYRRAYF VSARARSAGA DDMAFTWSDW QRGIEPWRFN
VPTSRAPTAD QRAHTVFDRT LLRAGETVSM KHYLRTETRT GFGLPARWPG TLVITHVGSG
QQFTQPLAWR STGTGGRSAE STFKLPPAAK LGSYSVELRQ DDTPAARPGE DGDDAGRTLT
TGEFRVEEFR LPVLEGRIAP VQQGPLVDAK AVPLQLRVGY VAGGGAARLP VRVSALVRPR
PLDFPDYGGF SFAPPRARAD AQSRGADDDD AGEEAPEAAT DTRVVADKLP VVLDAEGNGK
LSLPDLPAAA QPRDLLVEAT YADPNGELQT IRGTSTLWPA GVVVGLKTEG WVSVQKALRM
QALALDLAGK PKEGVALSVR AVSRTVTTSR KRMVGGFYTY DNSTDTQDLG EVCSGKSDSR
GLLQCETQLK SAGQVELVVT AKDGDGRSIQ AGGTVYVTRQ GEIWFGGEDH DRIDVLPEKK
SYEPGETARL QVRMPFRQAT ALVAVEREGI LETRVVQLRG QDPTVEIKVQ EGWGPNVYVS
VLALRGRLRE VPWYSFFTWG FKAPREWWTA FRYEGKEYVA PTALVDLSKP AYRLGMAEIR
VGTKAHRIEV KVAADKESYP VRGTARVTVR ATLPDGKPAA GAEVALAAVD QALLELMPNT
SWNLLEAMLQ RRAWGVETST AQMEIIGRRH FGRKAVPAGG GGGRSATREL LDTLLLWNPR
VVLDAAGQAQ VDVPLNDALT SFRIVAVADA GTGSFGTGQT TIRATQDLQI ISGLPPLVRE
GDEFRAQVTL RNTTAKPMTV EATARATLLD LAPQTVEIPA GGSREVSWNV TAPEPLGQTR
TEALLWEISA RDTATGATAR DALKARQRIV PAVPLSVQQA ALVQLDGPYW LDVAAPAGAL
PATGAKRGGI QLMLQPRLAE GLPGVRDWFA RYPFLCLEQK TSKAVGLADG ALWKGVAAEL
PTYLDKDGLA SYFPPREGQD DRGSDTLTAY LLAATHEASA LHPDFVLPQA ERDAMARGLA
AFVEGRIQRN FWSPQKDLDV RKLAAVEALS RYGLAQGRMV GSITVAPNQW PTHAVIDWLS
ILKRVQDVPQ RAQRLEEAQQ ILRGRLSYQG TKLVFSTEEG DYWWWLMANG DANTAKLMLA
VMDDPAWKDD MGRLANGFIA RQQGGAWHTT TANLWGGLAL EKFSAKFEAA PVAGTTRATL
GDASAQVDWS KVVRARPSDT GGAAHQRSFF GAPASPTGLS NNGMFLPWPA GATGATGATG
AAAGASGTAQ SPSTASPAGP GTLEVQQQGS GKPWLTVQSL AAVPRTAPFA AGYAVTKTVT
AVEQAQPGRT TRGDVLRIVL EVNASAPMTW VVLSDPIPGG ATILGSGLGR DSEIAAQAGK
KDTVDPGAAW LAYEERSFEA FRAYYEYVPK GVFKVEYTVR LNNVGAFSLP ATRVEAMYAP
EMFGEVPNAR VTVQAVP
//
