ID A0A0Q4HGQ1_9MICO Unreviewed; 1054 AA.
AC A0A0Q4HGQ1;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=ASE68_07410 {ECO:0000313|EMBL:KQM84540.1};
OS Agromyces sp. Leaf222.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Agromyces.
OX NCBI_TaxID=1735688 {ECO:0000313|EMBL:KQM84540.1, ECO:0000313|Proteomes:UP000050813};
RN [1] {ECO:0000313|EMBL:KQM84540.1, ECO:0000313|Proteomes:UP000050813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf222 {ECO:0000313|EMBL:KQM84540.1,
RC ECO:0000313|Proteomes:UP000050813};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQM84540.1, ECO:0000313|Proteomes:UP000050813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf222 {ECO:0000313|EMBL:KQM84540.1,
RC ECO:0000313|Proteomes:UP000050813};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQM84540.1}.
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DR EMBL; LMKQ01000001; KQM84540.1; -; Genomic_DNA.
DR RefSeq; WP_055860913.1; NZ_LMKQ01000001.1.
DR AlphaFoldDB; A0A0Q4HGQ1; -.
DR STRING; 1735688.ASE68_07410; -.
DR OrthoDB; 5240387at2; -.
DR Proteomes; UP000050813; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF59; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 23..324
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 328..633
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 44..51
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1054 AA; 110369 MW; C33F61832A84897F CRC64;
MPSSTAPSQP DATLVAPDSA ARAGGLAAGL VRRISEGVHH AVFGAPGSGK TTLAVELVAD
RVTRLGYGVD DVLVLCASRS TATALRDRIA VRLGVTTRGP LARTANSMAF QLVRAYTAAP
VTLLTGGEHD RIVADLVEGG IRDGFGPEWP EPLTPEVRVL RGFRTELRDL LMRAVELGVD
EHDLARLGEA AGRPEWVAAA AFMSEYADVK DQVRPNQFDS AELGAFAASI VRRSRVHPEA
SAALGPLAGL RMLVVDDAQE TTEASASLIA AFAACGVQIV AIGDPDVASN GFRGGRPELL
GSLSSMLDGA PVQRIELPTV HRGRPEIAEI VSGVRAHIGT ALGGTHRSAA LAGAEADAPA
DPLAPVLGIE AASSAAEHLA IASLLRERHL LDEVPWSQMA VVLRSGGDVP AVERALALAD
VPTAGAATGL ALRDAPAAAA LLTACSFVLG REPLTADLAV ALLTGPLGRL DGIGLRRLRL
ALRHEELAAG GTRTGDELLV DALSAPGGFV TIDAAPGRRA ARLAAVLDGA VQVARGGGTI
EEVLWSLWEG GGLGTEWGRQ AAGTGVLADE ADRSLDAAVA LFSAATRFVE REPGAPAVRF
VDEVLASELP EDSLAPRRTA ETVLVTTPQG VVGREFDVMV VAGLQDAVWP NLRPRGTLLH
AGLLPRVTQA ARSGSPLPGV ESPAEVRASV RDDELRMFVL AVSRARRQVV LACTSNDDEQ
PSVLMGYARE RVRPRRRPLQ LRPLVGALRR EAVTGDPESA AALALLAEEG VPGADPNEWY
GLAGLSNEAP LVDLEGDPEA SVQVSPSQID RVEESPLGWF VDHIASPPSG VAASIGTIVH
AVVEEIGARD DGETGVETIW AAVEERLKGV RFEAGWVAER ERRGARRMAE GAAEYLGSFD
DDAKLLLGAE GKFTITIDRV RITGTIDRIE ASPDGTTVIV DIKTGRTAPT FAQTAAHPQL
AAYQLAARES AVPSAGVLGG AKLVYVATPS RGLAYTERAQ QPFDDEADAA FRDRLAEVGR
VMAGSSFEGT TEPGHRSRFG SWQYRVHLVP AVSA
//
