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Database: UniProt
Entry: A0A0Q4LC04_9SPHN
LinkDB: A0A0Q4LC04_9SPHN
Original site: A0A0Q4LC04_9SPHN 
ID   A0A0Q4LC04_9SPHN        Unreviewed;       433 AA.
AC   A0A0Q4LC04;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   10-APR-2019, entry version 17.
DE   RecName: Full=UDP-glucose 6-dehydrogenase {ECO:0000256|PIRNR:PIRNR000124};
DE            EC=1.1.1.22 {ECO:0000256|PIRNR:PIRNR000124};
GN   ORFNames=ASF00_01330 {ECO:0000313|EMBL:KQN31477.1};
OS   Sphingomonas sp. Leaf34.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingomonas.
OX   NCBI_TaxID=1736216 {ECO:0000313|EMBL:KQN31477.1, ECO:0000313|Proteomes:UP000051932};
RN   [1] {ECO:0000313|EMBL:KQN31477.1, ECO:0000313|Proteomes:UP000051932}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Leaf34 {ECO:0000313|EMBL:KQN31477.1,
RC   ECO:0000313|Proteomes:UP000051932};
RA   Gilbert D.G.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KQN31477.1, ECO:0000313|Proteomes:UP000051932}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Leaf34 {ECO:0000313|EMBL:KQN31477.1,
RC   ECO:0000313|Proteomes:UP000051932};
RA   Schulze-Lefert P.;
RT   "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH +
CC         UDP-alpha-D-glucuronate; Xref=Rhea:RHEA:23596,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58052, ChEBI:CHEBI:58885;
CC         EC=1.1.1.22; Evidence={ECO:0000256|PIRNR:PIRNR000124};
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000256|PIRNR:PIRNR000124}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KQN31477.1}.
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DR   EMBL; LMLC01000001; KQN31477.1; -; Genomic_DNA.
DR   RefSeq; WP_055873064.1; NZ_LMLC01000001.1.
DR   EnsemblBacteria; KQN31477; KQN31477; ASF00_01330.
DR   GeneID; 29952111; -.
DR   OrthoDB; 647136at2; -.
DR   Proteomes; UP000051932; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   InterPro; IPR028357; UDPglc_DH_bac.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500134; UDPglc_DH_bac; 1.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52413; SSF52413; 1.
DR   TIGRFAMs; TIGR03026; NDP-sugDHase; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000051932};
KW   NAD {ECO:0000256|PIRNR:PIRNR000124, ECO:0000256|PIRSR:PIRSR500134-3};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000124};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051932}.
FT   DOMAIN      317    418       UDPG_MGDP_dh_C. {ECO:0000259|SMART:
FT                                SM00984}.
FT   ACT_SITE    263    263       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR500134-1}.
FT   BINDING      30     30       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      35     35       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      86     86       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     122    122       NAD; via amide nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     155    155       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     266    266       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     331    331       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
SQ   SEQUENCE   433 AA;  46422 MW;  3F586B3A8EAF5FD9 CRC64;
     MRITMIGAGY VGLVSGACFS DFGHDVCCVD LDQAKIDALH AGRMPIFEPG LDQLVASNVA
     AGRLTFTTDL TSAVAGADAI FIAVGTPSRR GDGHADLRYV FAATEEIAAA ITGPTVVVTK
     STVPVGTGDR VEAILREIRP DIDVAVVSNP EFLREGAAIG DFKRPDRIVI GTDDERAQQV
     MRDVYRPLYL GESPILFTSR RTSELIKYAA NAFLATKITF INEIADLCEA VGADVRDVSR
     GIGLDNRIGK KFLHAGPGYG GSCFPKDTLA LLKTAEDYQS PVHIVEAVVK VNDSRKRAMG
     RKVISALGDH PRGKTVALLG LTFKPNTDDM RDAPSLAIAT ALADAGVTVR AFDPEGMDAA
     KAMMPDLVYC GDAYEAAEGA DAVVLVTEWD AFRALDLLRL KDLLTVPVMI DLRNVYERAD
     LDALGFRYVA VGR
//
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