ID A0A0Q4Y0M2_9BURK Unreviewed; 506 AA.
AC A0A0Q4Y0M2;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:KQP20019.1};
DE EC=1.1.1.157 {ECO:0000313|EMBL:KQP20019.1};
GN ORFNames=ASF43_28060 {ECO:0000313|EMBL:KQP20019.1};
OS Pseudorhodoferax sp. Leaf267.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae.
OX NCBI_TaxID=1736316 {ECO:0000313|EMBL:KQP20019.1, ECO:0000313|Proteomes:UP000051560};
RN [1] {ECO:0000313|EMBL:KQP20019.1, ECO:0000313|Proteomes:UP000051560}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf267 {ECO:0000313|EMBL:KQP20019.1,
RC ECO:0000313|Proteomes:UP000051560};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQP20019.1, ECO:0000313|Proteomes:UP000051560}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf267 {ECO:0000313|EMBL:KQP20019.1,
RC ECO:0000313|Proteomes:UP000051560};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC {ECO:0000256|ARBA:ARBA00005086}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQP20019.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LMMV01000006; KQP20019.1; -; Genomic_DNA.
DR RefSeq; WP_056180296.1; NZ_LMMV01000006.1.
DR AlphaFoldDB; A0A0Q4Y0M2; -.
DR STRING; 1736316.ASF43_28060; -.
DR OrthoDB; 5287258at2; -.
DR Proteomes; UP000051560; Unassembled WGS sequence.
DR GO; GO:0008691; F:3-hydroxybutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:KQP20019.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000051560}.
FT DOMAIN 8..185
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 188..285
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 415..494
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 506 AA; 54357 MW; B8CD8742671C5535 CRC64;
MNKTYAVVGV VGAGAMGRGI AQIAAQAGST VKLFDVQAGA AATARAAVLL QWDKLHEKGR
LDAAELASRR ALLAEAGALS ALADCDLVIE AVVEKLDVKQ ALFAELETIV RPDTVLASNT
SSLSITAIAA RLQRPQRFAG YHFFNPVPLM KVVEVIGGLK TDPAVCDGLQ RYARDMGHTP
VLAQDTPGFI VNHAGRAYGT EALRIVGEGV ADFATVDRIL KDQVGFKLGP FELMDLTALD
VSHPVMESVY RQYYDEPRYR PSVITAQRLA GGVVGKKVGE GFYRYHDGVA QVPGEPVAPQ
VADIPPVWVS PRAARRAELL QLLKDLGARI ETGVSPSPQA LTVVSPLGFD VTTVAVVERL
DPARTIGIDM LVDDASTRRR VLATNPATRI DMREAAHALF ARDGKAVSVV RDSGGFVTQR
VVAAIVNIAS DICQQRICTP RDLELAVTLG LGYPLGPLAM GDRYGPANVL EVLFNMQTVY
GDPRYRPSPW LRRRGAIGLS LSHEEL
//
