ID A0A0Q5C857_9MICO Unreviewed; 827 AA.
AC A0A0Q5C857;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=ASF54_01860 {ECO:0000313|EMBL:KQQ27559.1};
OS Frondihabitans sp. Leaf304.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Frondihabitans.
OX NCBI_TaxID=1736329 {ECO:0000313|EMBL:KQQ27559.1, ECO:0000313|Proteomes:UP000051456};
RN [1] {ECO:0000313|EMBL:KQQ27559.1, ECO:0000313|Proteomes:UP000051456}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf304 {ECO:0000313|EMBL:KQQ27559.1,
RC ECO:0000313|Proteomes:UP000051456};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQQ27559.1, ECO:0000313|Proteomes:UP000051456}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf304 {ECO:0000313|EMBL:KQQ27559.1,
RC ECO:0000313|Proteomes:UP000051456};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQQ27559.1}.
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DR EMBL; LMNV01000002; KQQ27559.1; -; Genomic_DNA.
DR RefSeq; WP_055958109.1; NZ_LMNV01000002.1.
DR AlphaFoldDB; A0A0Q5C857; -.
DR STRING; 1736329.ASF54_01860; -.
DR OrthoDB; 9806486at2; -.
DR Proteomes; UP000051456; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 2.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:KQQ27559.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000051456};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 19..472
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT REGION 533..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 827 AA; 87774 MW; 3A19D1CB5E32D741 CRC64;
MTTTDSTGSS PTGERIEEID VSSEMQGSFL EYAYSVIYSR ALPDARDGLK PVQRRILYMM
SEMGLRPERG HVKSARVTGE VMGKLHPHGD SAIYDALVRL AQDFTMRLPT IDGHGNFGSL
DDPPAAARYT EVRLAPAAMA MNEGLGEDVV GFVPNYDNQL MQPEVLPAAF PNLLVNGGSG
IAVGMATNMA PHNLVEVIGA ARHLIEHPEA TLDDLMAFVP GPDLPTGGTI AGLAGVRDAY
ATGRGSFKVR AKVSIENLTA RKKGLVFTEL PYMIGPEKII EKVKDGVNAK KLTGISDIND
FSDRHHGMRL IIDIKTGFSP EAVLEQLYRH TPLEDGFSIN NVALVEGQPR TLGLKELLEV
YVAHRLEVVT RRSRYRLQKR EDRLHLVEGL LIAILDIDEV IQVIRTSDDS EAAKTRLREV
FDLSDLQAEY ILELRLRRLT KFSRMELEAE RDELLAAIAS LRELLSDPAK LRALVSSELA
DIADEYGTPR RTLLTEAAPS VASTRKNAPV VEVADVPTRV YLSTTGRLLR VDLQDPAAAD
TESGAGPVPP SRRTKHDAIR SSVTTTTRAE IGAVTSTGRL IRFSPVDLPA APPTSVQLGA
GVPVKDYLGL SSASSPSSEK VLALVSLDSA DPVALGTAQG VVKRVTPGAW PSKPEFPVIA
LKPGDSVVGV AQGPDSDELV FVTTSTQLLR YPAALVRPQG TAGGGVAGIS LAARATVLFF
GAVPATASAV VATISTSAAT IAGADPGRAK ISDFADYPAK GRATGGVRAH ALLKGEDGLS
VAWVGVAPAI AVAADGGVRK LPETLVRRDA SGTPLDTVVG SIGGAVS
//
