ID   A0A0Q5JWJ6_9MICO        Unreviewed;       821 AA.
AC   A0A0Q5JWJ6;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE            EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN   ORFNames=ASF76_06360 {ECO:0000313|EMBL:KQR25258.1};
OS   Microbacterium sp. Leaf151.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Microbacterium.
OX   NCBI_TaxID=1736276 {ECO:0000313|EMBL:KQR25258.1, ECO:0000313|Proteomes:UP000051582};
RN   [1] {ECO:0000313|EMBL:KQR25258.1, ECO:0000313|Proteomes:UP000051582}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Leaf151 {ECO:0000313|EMBL:KQR25258.1,
RC   ECO:0000313|Proteomes:UP000051582};
RA   Gilbert D.G.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KQR25258.1, ECO:0000313|Proteomes:UP000051582}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Leaf151 {ECO:0000313|EMBL:KQR25258.1,
RC   ECO:0000313|Proteomes:UP000051582};
RA   Schulze-Lefert P.;
RT   "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KQR25258.1}.
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DR   EMBL; LMOR01000002; KQR25258.1; -; Genomic_DNA.
DR   RefSeq; WP_055954650.1; NZ_LMOR01000002.1.
DR   AlphaFoldDB; A0A0Q5JWJ6; -.
DR   STRING; 1736276.ASF76_06360; -.
DR   OrthoDB; 9806486at2; -.
DR   Proteomes; UP000051582; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR006691; GyrA/parC_rep.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 3.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:KQR25258.1};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          21..474
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
SQ   SEQUENCE   821 AA;  87345 MW;  8F327F47D1706CA6 CRC64;
     MPDSRSSSAA TSPVVERIED VDVSTEMQGS FLEYAYSVIY SRALPDARDG LKPVQRRILY
     QMAEMGLRPD RGHVKSARVV GEVMGKLHPH GDAPIYDALV RLAQHFTLRV PLVDGHGNFG
     SLDDGPAASR YTEARLAPPA LALTENLDED VVDFIPNYDG QFQQPEVLPA AFPNLLVNGA
     TGIAVGMATN MAPHNLVEVV SAATHLLQHP DATVEELMEF VPGPDLPTGG IIVGLDGIKD
     AYTNGRGTFR TRAKASIESL GPRRTGIVIT ELPYLVGAER VIEKIKDAVQ AKKLAGIADV
     TDLSDRHHGL RLVIGIKTGF DPKAVLEHLY RLTPLEDSFG INNVALVDGQ PQTLGLRDLL
     RVYLDHRVRV VTRRSEYRLA RRRERLHLVE GLLIAILDID EVIQVIRSSD DGEQARAKLQ
     EVFDLSHPQA EYILELRLRR LTKFSRIELE AERDQLNAEI AQLVELLGSE TLLRQQVARE
     LDAAAEAYGT PRRTLLLNGG PVQPRSAKAA AAADLQIADA PCRVYLSATG RMVRAELVAD
     APGGGVVAPT RRSKHDAIRS SVDTTTRGDI GAVTSAGRLV RFSPVDLPSV PANSVQVAAG
     MKVEQYLALG KGETVIGLVP LTDGPTIALG TEQGVVKRVA ASELGTKDEI EIIALRDGDR
     VVGAAPAGDN AELVFVADDA QLLRFDASSV RPQGRSAGGM AGIRLSDGAR AIAFAVVGAS
     AFDAVVVTVA GSSAALAGAD AGSAKVSAFT EFPAKGRATG GVRAQRLLRG EDALVLAWVG
     IEPRAVGTDG SVRALPEPGA KRDASGQPLD AAVGAIGTVV R
//