ID A0A0Q5PVH6_9FLAO Unreviewed; 1002 AA.
AC A0A0Q5PVH6;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=ASG01_14765 {ECO:0000313|EMBL:KQR90824.1};
OS Chryseobacterium sp. Leaf180.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC Chryseobacterium group; Chryseobacterium.
OX NCBI_TaxID=1736289 {ECO:0000313|EMBL:KQR90824.1, ECO:0000313|Proteomes:UP000051405};
RN [1] {ECO:0000313|EMBL:KQR90824.1, ECO:0000313|Proteomes:UP000051405}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf180 {ECO:0000313|EMBL:KQR90824.1,
RC ECO:0000313|Proteomes:UP000051405};
RX PubMed=26633631; DOI=.1038/nature16192;
RA Bai Y., Muller D.B., Srinivas G., Garrido-Oter R., Potthoff E., Rott M.,
RA Dombrowski N., Munch P.C., Spaepen S., Remus-Emsermann M., Huttel B.,
RA McHardy A.C., Vorholt J.A., Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiota.";
RL Nature 528:364-369(2015).
RN [2] {ECO:0000313|Proteomes:UP000051405}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf180 {ECO:0000313|Proteomes:UP000051405};
RA Garrido-Oter R., Mueller D.B.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000051405}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf180 {ECO:0000313|Proteomes:UP000051405};
RA Vorholt J.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQR90824.1}.
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DR EMBL; LMPJ01000014; KQR90824.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0Q5PVH6; -.
DR STRING; 1736289.ASG01_14765; -.
DR OrthoDB; 32195at2; -.
DR Proteomes; UP000051405; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR046817; MmeI_N.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR025931; TaqI_C.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF20464; MmeI_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR Pfam; PF12950; TaqI_C; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000051405};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 36..165
FT /note="MmeI-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF20464"
FT DOMAIN 366..680
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT DOMAIN 759..877
FT /note="TaqI-like C-terminal specificity"
FT /evidence="ECO:0000259|Pfam:PF12950"
SQ SEQUENCE 1002 AA; 117060 MW; 1D6FC9164A25DFAE CRC64;
MEMFQKTIVN KYLKSQNTDL ISSKWNLFTA HFHHPEIQEN IRQSKEEQYQ GEFLIDLFVN
IFGYTKNPTP AYNLTTEYKN VKDSKKADGA IVITGSVKAI IELKGTKTTD LSKIEEQAFG
YKNNQPDCKY IITSNFEKLR FYIDNAIEHL EFNLFELKFE EFQLLYLCLA FENIAAGIPG
KIKDESLSQE DVITKKLYKD YSLFKRELFQ NLLVLNPEID QLELFKKSQK LLDRFLFLFF
GEDSGLLPPN SVRMILEQWD KLRDLDEYVP LYDRFRKYFT YLNTGFKGKQ FDVFAYNGGL
FKPDEILDTI QIDDQLLYTH TMRLAEYDFQ SEVDVNILGH IFENSLNEID EIKAQLAGEV
IDKSKTKRKK DGVFYTPKYI TKYIVENTVG KLCEEKKAEF TIVEEEYFTD RKRQQKTKAA
LLQKLYDYRD WLHQITIIDP ACGSGAFLNE ALNFLITEHQ YIDELEAKLT GSSIAFTYHS
ESILENNLFG VDLNEESVEI AKLSLWLRTA EKNRKLNSLN SNIKCGNSLI DDPEIAGDKA
FNWEQEFPQV FSKGGFDVVI GNPPYGVNFN ENEKKFLSNF DDFVPDFEIY IYFISLYKKV
LRTNGVLSYI FPNTFLATVF GKKYREMIFK NVQVYEIVDL SQDNTFADAA VRTCIFSFTN
SSKDYKTYLK KIQNKQFIEL VCYEKSDILK EVENVLSLFS QNKIEKLIIS KLSENQILAN
FLEVSQGLIP YDKYRGHDEE TIKNRIWHAN YKKDDTFQKE LKGGDVWRYG IHWNEELWIS
YGDWLAAPRK KEYFTNARLL IREILSGNLF CTWTEEEFYN TPSIINIINK KDLLDLKFAL
PLINSKLIGW FTYKTSPKAN KGLFPKILVG DVKKIPIKEI PSESQKPFII KADQMLSLNK
ELQEVNAKFL RIFKEEYKIN KLSKKLEGWY KLSFSEFLAE LKKQKVELSL SQKADLEEYF
DREKTKAVDL QSTIAGTDKE IDQMVYALYG LTEEEIAVVE NS
//
