ID A0A0Q5T189_9BACT Unreviewed; 2018 AA.
AC A0A0Q5T189;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Alpha-2-macroglobulin {ECO:0000313|EMBL:KQS24839.1};
GN ORFNames=ASG33_24140 {ECO:0000313|EMBL:KQS24839.1};
OS Dyadobacter sp. Leaf189.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Spirosomataceae;
OC Dyadobacter.
OX NCBI_TaxID=1736295 {ECO:0000313|EMBL:KQS24839.1, ECO:0000313|Proteomes:UP000051810};
RN [1] {ECO:0000313|EMBL:KQS24839.1, ECO:0000313|Proteomes:UP000051810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf189 {ECO:0000313|EMBL:KQS24839.1,
RC ECO:0000313|Proteomes:UP000051810};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQS24839.1, ECO:0000313|Proteomes:UP000051810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf189 {ECO:0000313|EMBL:KQS24839.1,
RC ECO:0000313|Proteomes:UP000051810};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQS24839.1}.
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DR EMBL; LMPS01000008; KQS24839.1; -; Genomic_DNA.
DR RefSeq; WP_056291573.1; NZ_LMPS01000008.1.
DR STRING; 1736295.ASG33_24140; -.
DR OrthoDB; 9767116at2; -.
DR Proteomes; UP000051810; Unassembled WGS sequence.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF01835; MG2; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000051810};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..2018
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006262371"
FT DOMAIN 1249..1339
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 2018 AA; 229711 MW; F54CBE615E7A6609 CRC64;
MKTSYSATIL LSTLFLILNT MHANSQNPIK TYDANWKKVA DLQATGLAKS ALTGVREIYR
LARQEKQDAQ VIKAAIAMVN LQSEFREDNE IAAIKDLEAE LANSSGVVNS IFSSLLASYY
YNYYQQKRWQ LYQRTETTGF LKEDIDTWST TDFHHRIAEL YLASLSNENE LQQTKLEPFD
AIITKGNARQ LRPTLYDLLA HNALRYFSSD EPELKRPGYA FEINSASAFD PAADFIHRHF
ETKDSTSLEL YALKLYQKLI AFHMHDPVAD ALIDVDLARI QYVKQKSVHE NTDELYYLAI
NHVANQYQQT PAAAQAWYLL AQYHFDLGTA YKIREDSTNR FAKVQAVSIC KEIIRQNPTS
EGGVNAANLL SRIRQKALQF NAEQVLVPAK PFLIFVEYQN INKLYLRLVN STPSLLKDFD
RRNSDAFWRT VSKATAIRNW EQTLPDTKDY QEHSVEIKAD ALPAGEYMLL ASSSPDFSDT
QSIGGVRLLY VSNISYIQRE RDYFVLHRDT GQPLAGATVK RWDSAFDYQT RTYKKSLAAH
YTTDKNGYFK ESMPSQSKVQ SESFEMLHGN DRLFIQESIN TYYNDEEEKE DAGTTIYLFT
DRSLYRPGQT VYFKGIVAEG TSVLKDKTRK IEVKLQNANY EEVETVTKTV NDFGSFSGSF
VLPGTSLNGE FSILADDDYS VSFQVEEYKR PRFAVSFDTL RNTYKLGDTI RVTGTGTAYA
GNRIDGAKVV YRVVRNERFL YPWTRRASYF PLSPPKEITH GETVTDQEGH FYVSFEAIPD
AKSDRNFDPV FNYTIYADVT DTNGETRSAE TSVSVGYKSL LIKAEIPERV SADDFTQLKI
RTENMNGEFV SAEAKVKLTR LIPESRLIRS RYWAQPDMFV MTKSEFIASF PNDEYNNETE
KENWPEQKVV FEKSQALTAD KELAFPGGKV AAGFYKIDIA ATGQDGDEVK DTRYIELTEE
TNPKLLKPEY QWTKSGPAVE PGEKTNVQFA TSAPDVFLIS TSGRTENPAN FSFLKLNDEK
RTFPILAKEA DRGGYAIDYV FVKHNRVHQA QNFVNVPWTN KELTIEYATF RDKALPGSKE
QWKVKISGYR KGQVAAEMLA SMYDTSLDQF YQHQWTKPGH WPTGRTLNRW GNGINFTPKD
ATIVNFLFTS EKAFEKSYDQ LIDPDIIRMS SGGGRNARYR RSLSMDQLSY KKGEMHEEEI
ATSVPAPPML GDATRELQEV VTVGYGQTKP KSPAAEPEKT KVRKNFNETA FFLPDLKTDE
NGAITFSFTL PEALTRWKFQ ALAHTPELAF GYSKKEIVTQ KELMVQPNAP RFLREGDQIL
FPAKIVNLSD RTLNGNATLQ LFDPATNENV TAHFGLISNE KAFSITAGQS ATVDFNLNIP
AGYHHALTWR VVAKAANLSD GEENTLPVLS NRMLVTESLP LTMRGSGKKE FRFEKLINSA
NSKSLAHESV TVEYTSNPAW YAVQALPYLI EYPHECAEQT WNRYYANAVA SNIVSKSPRI
AAIFNSWKTV DTAALASNLQ KNQELKSLLL EETPWVLAAK SESEQKRNIA LLFDLIKMKG
ELDTYLAKLR EMQNESGGFP WFKGGHKDRY ITQYIVTGIG RLLQKKVIAE NRDINAIIEK
AFPYLDRQIK EDYDRLIKNQ VNMQEYVPGP QQVQYLYMRT CFDDAPIETT AFDAYEFFLQ
RARASWPKQS KYMQGLIALM LHRSKDAATP KAILKSLRET SISNEELGMY WKNTRSWWWH
EAPIEQQALL IEAFHEIAGD SATVDKLKTW LLKNKQTNRW ESTRATAEAC HALLLTGNNW
LVEEKAPTVR IGSEVIKPDN VESGTGYFKK AFESSVVNAE MGKIEVDISS SSNSKSPSWG
AVYWQYFEDL DQITFSETPL KLSKKLFIQT NTDRGPVLSE VKEGDSVKVG DKIVVRIELR
VDRDMEYVHM KDMHAAALEP VNVLSGYKWQ GGLGYYESTK DASTNFFFDR LRKGTYVFEY
QLFVNHQGNF SNGITSIQCM YAPEFTAHSE GIRISIRK
//
