ID A0A0Q5UJQ7_9SPHN Unreviewed; 499 AA.
AC A0A0Q5UJQ7;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:KQS48473.1};
GN ORFNames=ASG20_15420 {ECO:0000313|EMBL:KQS48473.1};
OS Sphingomonas sp. Leaf198.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=1736299 {ECO:0000313|EMBL:KQS48473.1, ECO:0000313|Proteomes:UP000050871};
RN [1] {ECO:0000313|Proteomes:UP000050871}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf198 {ECO:0000313|Proteomes:UP000050871};
RA Garrido-Oter R.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000050871}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf198 {ECO:0000313|Proteomes:UP000050871};
RA Vorholt J.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQS48473.1}.
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DR EMBL; LMPX01000003; KQS48473.1; -; Genomic_DNA.
DR RefSeq; WP_056054634.1; NZ_LMPX01000003.1.
DR AlphaFoldDB; A0A0Q5UJQ7; -.
DR STRING; 1736299.ASG20_15420; -.
DR OrthoDB; 462203at2; -.
DR Proteomes; UP000050871; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000050871}.
FT ACT_SITE 82
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 17..20
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 82
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 331
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 340
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 344
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 499 AA; 55276 MW; 81D8757AA65024D8 CRC64;
MNDTSEPPRT RVVVAGGGTA GWIAAAAIVR QLGSLVDVTL VESDEIGTVG VGESTIPTAR
SFHAFLGIDE AAFMRATQAT FKLGIAFENW RQVGDRYFHP FGSIGRSVAI ADFQHFWLEA
RARGFGEAYG DYSLEQQAAG AGLFGHDEQH SLAYAYHLDA TAYARFLRAL AEPWGVRRVE
GCIERVERDG EGGYIAALVL ASGERISGDL FVDCTGFRAL LTEGTLETGF EDWSEWLATD
RALAVQTETV GPPVPYTRAI AHGAGWRWQI PLQTRTGNGL VYSSGHMSDD EAHETLIGAL
DGRTLFEPRP LRFRSGMRRQ AWNRNCIALG LAAGFIEPLE STSIHLIMNA VIRLIQLFPF
RGDDHGALAS RFNAQSRHEW EHVRDFIILH YHVTQRDDSA FWRDCARMTI PDSLAERIAL
FTKTAGAWQG QDDLFRIDSW VSVMLGQGVV PRAHHRIASI IKGQELRTSF EDLSRGIAST
VRLLPRHCDF LARYCPADG
//
