ID A0A0Q5UYP8_9CAUL Unreviewed; 512 AA.
AC A0A0Q5UYP8;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:KQS54390.1};
GN ORFNames=ASG17_12205 {ECO:0000313|EMBL:KQS54390.1};
OS Brevundimonas sp. Leaf363.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Brevundimonas.
OX NCBI_TaxID=1736353 {ECO:0000313|EMBL:KQS54390.1, ECO:0000313|Proteomes:UP000051182};
RN [1] {ECO:0000313|EMBL:KQS54390.1, ECO:0000313|Proteomes:UP000051182}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf363 {ECO:0000313|EMBL:KQS54390.1,
RC ECO:0000313|Proteomes:UP000051182};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQS54390.1, ECO:0000313|Proteomes:UP000051182}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf363 {ECO:0000313|EMBL:KQS54390.1,
RC ECO:0000313|Proteomes:UP000051182};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQS54390.1}.
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DR EMBL; LMPZ01000003; KQS54390.1; -; Genomic_DNA.
DR RefSeq; WP_056104114.1; NZ_LMPZ01000003.1.
DR AlphaFoldDB; A0A0Q5UYP8; -.
DR STRING; 1736353.ASG17_12205; -.
DR OrthoDB; 5695497at2; -.
DR Proteomes; UP000051182; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000051182}.
FT ACT_SITE 83
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 17..20
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 83
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 190
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 337
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 346
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 350
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 512 AA; 57377 MW; 80C9FA303EF98089 CRC64;
MEAKAPNALR KVCVVGGGTA GWVAAALMAE HFKGKLFEIE LVESDDIGTI GVGESTVPPF
LQLLAKLGVN EQEFIRETQA SFKLGIEFKD WLEKGQSYFH PFGTIGLPID LSDFYQVWLK
AKLAGYDRPL QDFAPASVMA REGKFTLPFK AQRTPLAGAS YALHVDAKRV AQFLRRFAEA
RGVTRTEGMV SEVQTRADGF VEQLVLKDGR TVEADFFIDC SGFRALLIGK TLDVGYEDWS
HWLLCDRAIA VQTENVGPPP PYTLAHAQDY GWRWRIPLQH RAGNGYVFSS QYLSDDEATA
TLMAQVEGKP VVDPMVVPFR TGVRDRIWDK NVLALGLAGG FIEPLESTAI HLIYRGMDFF
FRFLPDRDCA PELATEYNRR MRADYEEIRD FIILHYCVTR RTDTPFWDAC RTMTVSESLQ
RKIDLFRING TVAEGLDELF RDPNWQSVLD GMGVVPRTYH PLVDRIPFGR ATDGLDEAVA
NLERMVAGLP DHQSFIAQHC AAERPTAPVV AA
//
