ID   A0A0Q6BJ60_9PROT        Unreviewed;       691 AA.
AC   A0A0Q6BJ60;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Diguanylate cyclase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=ASG34_06545 {ECO:0000313|EMBL:KQT42405.1};
OS   Methylophilus sp. Leaf416.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC   Methylophilaceae; Methylophilus.
OX   NCBI_TaxID=1736373 {ECO:0000313|EMBL:KQT42405.1, ECO:0000313|Proteomes:UP000050891};
RN   [1] {ECO:0000313|EMBL:KQT42405.1, ECO:0000313|Proteomes:UP000050891}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Leaf416 {ECO:0000313|EMBL:KQT42405.1,
RC   ECO:0000313|Proteomes:UP000050891};
RA   Gilbert D.G.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KQT42405.1, ECO:0000313|Proteomes:UP000050891}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Leaf416 {ECO:0000313|EMBL:KQT42405.1,
RC   ECO:0000313|Proteomes:UP000050891};
RA   Schulze-Lefert P.;
RT   "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KQT42405.1}.
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DR   EMBL; LMQS01000002; KQT42405.1; -; Genomic_DNA.
DR   RefSeq; WP_055828323.1; NZ_LMQS01000002.1.
DR   AlphaFoldDB; A0A0Q6BJ60; -.
DR   OrthoDB; 9813903at2; -.
DR   Proteomes; UP000050891; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 1.
DR   CDD; cd06225; HAMP; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   InterPro; IPR033417; CHASE8.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   PANTHER; PTHR44757:SF2; BIOFILM ARCHITECTURE MAINTENANCE PROTEIN MBAA; 1.
DR   PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR   Pfam; PF17152; CHASE8; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF158472; HAMP domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        14..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        151..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          178..231
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          281..413
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          422..676
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
SQ   SEQUENCE   691 AA;  78670 MW;  610E364EB4ABD905 CRC64;
     MLRLFRNLKI AEKLLLTELA MTLSMLLVFS IFALGNHYHD LRTHLIQNIL VQMNVVATSI
     GPAVMFDELS SAAKTLEPLS DNENIRTIVV LNQQQQTLES LHPLHAPITS AWQWLYPFFG
     DMELTAPIIV NEKAVGTLRA IIKQEQIVDM LIGFAWSNTI AAIAAALFGY FVMWRLNRYI
     VGPIHNLQTF VSNITQNHHY EQRIYTNSND EIGLLGKDIN NMLESISQRD AQLQKELDHR
     KEIEEKLQFL AHYDKGTLLL NRHAFEEIIT KKITTPIDER KHIYLLLLDL DRFKIVNDTF
     GHNTGDKLLQ QVAHRLRGNM SQEDAIFRLG GDEFAVILDA PKRTTIEQVC KRVIQNISTP
     FIVDDHEIHI GVSIGVATLR PGFDSKTEVM KNADIALYQA KDAGRNTYRF YSDEDETNTS
     ELRTLREELH FSLQNQELEL FYQPIIHTQH LKTIGFEALL RWRHPTRGLL APDQFIHLAE
     GSGLIISIGA WVIHQSLRQL AMWQQMFDKE LFMNVNISSR QLDDDSLSGT IRHALEHYHI
     APRTLNLEIT ESMVMRNIEA AKHILYALKQ LGIGIAIDDF GIGHSSMNYL KQLPVDILKI
     DKQFTSGIPH DKVDIAIVDA LVALAVSLNL KVVAEGVESA IQFEYLQYKL CHHVQGYLFS
     AALSASQTTA FMAEFPESIP ASFRKAVQQE T
//