ID A0A0Q6FAW4_9ACTN Unreviewed; 1062 AA.
AC A0A0Q6FAW4;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=ASG49_11220 {ECO:0000313|EMBL:KQT91660.1};
OS Marmoricola sp. Leaf446.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Marmoricola.
OX NCBI_TaxID=1736379 {ECO:0000313|EMBL:KQT91660.1, ECO:0000313|Proteomes:UP000051542};
RN [1] {ECO:0000313|EMBL:KQT91660.1, ECO:0000313|Proteomes:UP000051542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf446 {ECO:0000313|EMBL:KQT91660.1,
RC ECO:0000313|Proteomes:UP000051542};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQT91660.1, ECO:0000313|Proteomes:UP000051542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf446 {ECO:0000313|EMBL:KQT91660.1,
RC ECO:0000313|Proteomes:UP000051542};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQT91660.1}.
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DR EMBL; LMRF01000003; KQT91660.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0Q6FAW4; -.
DR STRING; 1736379.ASG49_11220; -.
DR OrthoDB; 9806690at2; -.
DR Proteomes; UP000051542; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000051542}.
FT DOMAIN 5..353
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 354..667
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 26..33
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1062 AA; 114027 MW; 88E501F7E84EC47B CRC64;
MRADYEVSAQ QWQAISAPLA PAVVIAGAGS GKTTLMAARV VYLVVTGQVR PDEVLGLTFT
TKAASELRSR IRDALVVAGV LGPDVRPAAL APGEDPEDAL EPTVVTYNAY AASLLADHGL
RIGHEPDTRV ITDASRFQLG ARAVERYTGD VQVLSDHPPT VIQNLLALDG AMTEHLVAPA
QVLALDAEAR AGFVRAHEEE VAGKNRKTYL EPLAKAVSAI DRRADLMGLV LSYRRLKADL
GLMDFADQIA LGARLAQEQP EVGALERSRF RVVMLDEYQD TSVAQAQMLA RLFSGPTPAA
GLGHAVTAVG DPNQAIYGWR GASVSNILGF GATFPAVDGP VPVLPLTVNR RSDRRILEVA
NTLAEPLYAA LPDVAPLVPA GDREGRVTTQ VFETADAELA WLLEEVRATH DPDGASGTRV
DWSDIGVLTR DNTTAEAVFD ALTAGGVPVE IVGLSGLLRL PEVAEVVAVL TLLHDVTANP
ALLTLLTGPR WAVGPRDLRL LGERATEIAG RRGRADGPVS IARELTEIAD GIDPAEAAAL
SDALADPGDA AYSPEALERF GLLAGELRGL RAAVGEPILD VVRRIVDTTG VDVELASAVS
PAAAARRDNL DLFLKAVAEF QAVDGDVTLP ALLAYLTAED DQGNGLDVAT PTEADSVKLL
TVHRSKGLEW HSVFVVGVCE TRFPSNRSRT LWTSSPAVLP APLRGDAADQ PQLHGHDKAA
LDAYRAATRA HDAEEELRLG YVALTRAARR LSVTSHLWGT RATPYGPSSY QQRLREQVEA
WGEEVTWLDK PEKGAPNPYD DVDRSSPWPL SGLGREATLR LAAAEVVRAS DPDGDDRDLD
MVETARVGDW DAEIDRLLTE ARADRAEVVD VPLPSSLSAT AVVRLREDPE SFARDLARPM
PRRPSPAARF GTRFHAWVEA RFGQQSLLDP DDLPGRGDLG IDDEDDLREL VVRFEAGPFA
DRVPHAVEAA FSLVLGGQVV RGRIDAVYAE PGGRWLVVDW KTSSHQDEDP LQLALYRLAW
ADLVGARLED VDAAFHYVRS GETARPPDLP DRAALEALVR PG
//
