ID A0A0Q6VAP2_9ACTN Unreviewed; 555 AA.
AC A0A0Q6VAP2;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=3-ketosteroid-delta-1-dehydrogenase {ECO:0000313|EMBL:KQV74602.1};
GN ORFNames=ASC61_06055 {ECO:0000313|EMBL:KQV74602.1};
OS Aeromicrobium sp. Root344.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Aeromicrobium.
OX NCBI_TaxID=1736521 {ECO:0000313|EMBL:KQV74602.1, ECO:0000313|Proteomes:UP000051702};
RN [1] {ECO:0000313|EMBL:KQV74602.1, ECO:0000313|Proteomes:UP000051702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root344 {ECO:0000313|EMBL:KQV74602.1,
RC ECO:0000313|Proteomes:UP000051702};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQV74602.1, ECO:0000313|Proteomes:UP000051702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root344 {ECO:0000313|EMBL:KQV74602.1,
RC ECO:0000313|Proteomes:UP000051702};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQV74602.1}.
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DR EMBL; LMDH01000001; KQV74602.1; -; Genomic_DNA.
DR RefSeq; WP_056210448.1; NZ_LMDH01000001.1.
DR AlphaFoldDB; A0A0Q6VAP2; -.
DR STRING; 1736521.ASC61_06055; -.
DR OrthoDB; 9813348at2; -.
DR Proteomes; UP000051702; Unassembled WGS sequence.
DR GO; GO:0033765; F:steroid dehydrogenase activity, acting on the CH-CH group of donors; IEA:UniProt.
DR GO; GO:0008202; P:steroid metabolic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR PANTHER; PTHR43400:SF7; FAD_BINDING_2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43400; FUMARATE REDUCTASE; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000051702}.
FT DOMAIN 6..533
FT /note="FAD-dependent oxidoreductase 2 FAD binding"
FT /evidence="ECO:0000259|Pfam:PF00890"
SQ SEQUENCE 555 AA; 59727 MW; F599D254E9894427 CRC64;
MEQTCDVIVV GAGGAGMTAA LAAAKRGLDT VVIEKSAYFG GSTARSGGGV WIPGNRALRK
AGQVEADDAE QARTYLDSIV GDAVPKERRD TFLERGPEVI DFLLDNTPVQ LKWVPEYADY
LPEQPGGRPR GRSVEPVPMD GRILGAELER LHPPYAKAPA NLIVTQADFR KISLGIRTLR
GPLTMMRVML KRVLSSLRGR RMYAMGNALT ISLRKGLMDA GVPVHYETPL TGLVIEGGRV
VGIRAEHEGA EVVIRARRGV ILGSGGFEKN DALREKYLPS PTEAGWSTGA ATNTGAGIEA
GVAVGAATDL MDDAWWGPTI PLPSGPWFCL AERNLPGSII VNSAGQRFMN EALPYVEATH
AIYEGEATGV PHVPAWLVMD QRYRNRYLFA GLSPRQPFPG RWYKFGTVRK ADSLARLAAE
IEVPAEALEE TIRRFNGFAE SGIDEDFHRG ESAYDRYYAD PRVKPNPSLH SIDRGPFYAV
KIVPGDLGTK GGIVTDERAR ALRADGSVIE GLYAAGNCSS AVMGRTYAGP GATIGPAMTF
GYLAAEDIAR TVGTD
//
