ID A0A0Q6W1E9_9BURK Unreviewed; 1905 AA.
AC A0A0Q6W1E9;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Alpha-2-macroglobulin {ECO:0000313|EMBL:KQV85105.1};
GN ORFNames=ASD15_08270 {ECO:0000313|EMBL:KQV85105.1};
OS Massilia sp. Root351.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Telluria group; Massilia.
OX NCBI_TaxID=1736522 {ECO:0000313|EMBL:KQV85105.1, ECO:0000313|Proteomes:UP000051876};
RN [1] {ECO:0000313|EMBL:KQV85105.1, ECO:0000313|Proteomes:UP000051876}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root351 {ECO:0000313|EMBL:KQV85105.1,
RC ECO:0000313|Proteomes:UP000051876};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQV85105.1, ECO:0000313|Proteomes:UP000051876}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root351 {ECO:0000313|EMBL:KQV85105.1,
RC ECO:0000313|Proteomes:UP000051876};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQV85105.1}.
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DR EMBL; LMDJ01000012; KQV85105.1; -; Genomic_DNA.
DR RefSeq; WP_057155953.1; NZ_LMDJ01000012.1.
DR OrthoDB; 9767116at2; -.
DR Proteomes; UP000051876; Unassembled WGS sequence.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF11974; bMG3; 1.
DR Pfam; PF01835; MG2; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000051876};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1905
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006295319"
FT DOMAIN 1014..1170
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 1228..1318
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT REGION 797..828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..817
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1905 AA; 205563 MW; 635DF21F918954B5 CRC64;
MRAISTLALL CLLPVAVQAQ TLVEAFSPQD AVKGVRQVKA RFSAQMVPFG EPRLSDPFDA
DCGAGQGAGT GAGEPAPVAA GKGRWVDGRN WVYDFERDLP AGVACRFTLK AGLADVEGRR
LGGARSYSFN TGGPSIVTSL PHEGAGYLDE NQIFVLTLDA PAREADIAQH AYCTAEGINE
KIAVRLLTGK ERQQVLDGRK MRPGRDGKTP VSVVQCKRSL PQNAKVTLVW GAAIATPGGL
ANAHDQVLSF KTRPDFTATF HCERPSAKGH CIPFQPVRVS FSAMVRTADA RAIAITGPGG
KRWGPKLSKE DERAEYVSGV LIVGPFPEKA RLRLVLPDAL KDDAGRSLLN QARFPLAVQT
GEMPPLVKFP ARFGIIEARG DRLLPVTVRN VEAGIAGRMA KASGAAGAML TVEGPDEQQD
RQVMDWLRRL HGAKRSAGWV PGELWGLKES VFTEPKGSPK PKTERFTLPK PGGGKAFEVI
GIPLRKPGFH VVELASPKLG LALQGKPSMA YVSAAALVTN MVAHFKHGAE SSLVWVTSLD
KGLPVPNAQV AVRACSGKLL WQGKTDANGV ASIREELFHD GCPYSEGYFV SARSGADMTF
TLSNWSEGIE PWRFNVPTDD LRADKTIATT VFDRTLLRAG ETVHMKHFIR RRSSDGFAYA
TQPGKETRLV ITHQGSAQKY ELPLVWSSGG VAESSWTIPA DAKQGEYDVL YEGRVGGVFR
VEQFRVPTMK ALLQGPPAPV VQAEQVALDL QLSYLSGGGA AGAQVKLRTT QQPRGVHFED
YDDFAFAMGD VRAGKVEQSA SFEGDGDDGE EPGMAEEEGQ GEAGAPVQTR NLTLDRAGGA
RFVVDKLPKL EQPATLLAEM SYQDANGETL SSATTIALWP SNYVIGIKPD NWVLSKTALK
FQVAVLDTQG KPVAGAPVDV DFFQRLNYSH RRRLVGGFYA YENNSEIKAL GKACEGKTDA
KGLLICEVAA PEAGNLILRA RTQDGEQRAA VTSRETWVAD GDAWWFKASD DDRIDLLPER
KRYEPGETAS FQLRMPFREA TALVTVEREG ILDTYVKHLS GASPVFSIPV KPNYAPNMFV
SALVVRGRVA GVQPTALVDL GKPAYKMGVA QLKVGWAAHE LKVAVNTDQQ TYKVRQKAQV
SVKVTRADGT PAPAGAEVAL AAVDVGLLEL MPNASWDLLE TMMRQRGLQV ETSTAQMQVV
GKRHFGRKAV PHGGGGGKGG GRELFDTLLF WKGRVKLDAN GEASVQVPLN DSLTAFRIVA
IASANTGLFG SGRAEIRSTQ DLMLLSGLPA VVREGDKFRA GFTLRNATAG DLKVELGAQV
SGKALPRQSV AIAAGMAQEI GWDYQVPSGA SELAWDVTAH TSGMPAAGAL AAEPGAAPAA
SSDRLRVKQA VRTAVPVRTL QATLLQLDQP QTMKVEIPAD ALPGRGGVRT LFAARLGSEL
PGVRDYMQAY PYTCFEQNTS RAIALRDRER WQHLAAQLPA YLDHDGLLKY FPVMEQGSDT
LTAYVLSAVQ EAGFPIPGDA KARMEEALLN FVQGRITRGS PLATADLAVR KVAALEALSR
VNRVTGAELE SFSPEPNLWP TSAVIDWYLI HQRVQGLPER DKRLAQAQQI LRSRLNLQGT
TMGFSTERND NWWWLMVSGD VNANRLLLAM TDNPSWQSDI GRLARGALGR QHKGRWNTTV
ANAWGVLALD KFSDKFEREP VAGSSTASIG NASKSVALDA KATSGSALLA WPRGAAELSL
KHAGSGKPWV TVQSLAAIPL KAPVSSGYKI VKTITPVEQA VKGAWTRGDV YRVRLDLEAQ
ADMTWVVVDD PIPASASVLG TGLGKDSQLL TAGEKSQGWV WPAFQERTFE AFRSYYEFVP
KGKWSVEYTV RLNNAGQFQL PPTRVEAMYS PEAFAELPNA AVSVK
//
