ID A0A0Q7BCH1_9ACTN Unreviewed; 712 AA.
AC A0A0Q7BCH1;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:KQW48427.1};
GN ORFNames=ASC77_06605 {ECO:0000313|EMBL:KQW48427.1};
OS Nocardioides sp. Root1257.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Nocardioides.
OX NCBI_TaxID=1736439 {ECO:0000313|EMBL:KQW48427.1, ECO:0000313|Proteomes:UP000051939};
RN [1] {ECO:0000313|EMBL:KQW48427.1, ECO:0000313|Proteomes:UP000051939}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root1257 {ECO:0000313|EMBL:KQW48427.1,
RC ECO:0000313|Proteomes:UP000051939};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQW48427.1, ECO:0000313|Proteomes:UP000051939}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root1257 {ECO:0000313|EMBL:KQW48427.1,
RC ECO:0000313|Proteomes:UP000051939};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQW48427.1}.
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DR EMBL; LMDV01000008; KQW48427.1; -; Genomic_DNA.
DR RefSeq; WP_056151123.1; NZ_LMDV01000008.1.
DR AlphaFoldDB; A0A0Q7BCH1; -.
DR STRING; 1736439.ASC77_06605; -.
DR OrthoDB; 9766847at2; -.
DR Proteomes; UP000051939; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000051939};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 15..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 60..249
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 302..669
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 712 AA; 77018 MW; 973B966281CB27B1 CRC64;
MSPQNQNATQ RTGRLRLLVI QALVFSLFAT LFVRLYYLQV VGGDEYHAQA TSQSVREVVV
QPQRGLIVDD MGRPLVANRT SWVVSIDRTV LGKLDEHQQK VLLERVAGVV DVPAHRIRKQ
LVTCGDEGSE PGVCWNGSPY QPVPVAEDVK KSVALRVLEQ PEDFPGVVAE QQSVRAYPQP
YGINLAHVLG YLSPITEDEL DQAEQDDDTS VNGASSVGRA GIEKEYDRWL RGMPGYKSVA
VDSMGRVLGD DGEVAGEPGN TLVTSIDAKV QGIVERQLAD TIATARTQYD PVTHKNYVAD
SGAAVVMEAK TGRIVAMASQ PTYDPSEWVG GISKKQLARL YSAQADNPLL SRATQGQFAP
GSTWKPFMST GALSDDLGPD TRLGCTSGLQ IGNRWFKNYE SESYGNIGFA EALNVSCDTF
FYRVGLHFWQ KYGSDPADSK AKDPLAAAAH TFGFGEKTGI DIPGEASGRV GDRVWRASYY
ASMKDYYCSM DRKGTAKTAF LKLFAHEFCL EGNYFRQGDS ANFTIGQGDT IVTPIQLARA
YAALSNGGTL YAPRVGKAIV GPDGALVKKI PPKVVGHAKV TRQAIDYVDN ALLGTVRSDG
AWNGTLAWKF GDFPLDRVHL RGKTGSAEVE GKQSTSWVAT YDKDYVVIMM VTQAGTGSGT
SGPAVRKIWE ALYGIDGMTV NPKKAAIAGT TPPSALPTFM RDGSILPPKK GD
//
