ID A0A0Q7K0B0_9ACTN Unreviewed; 1133 AA.
AC A0A0Q7K0B0;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Error-prone DNA polymerase {ECO:0000256|HAMAP-Rule:MF_01902};
DE EC=2.7.7.7 {ECO:0000256|HAMAP-Rule:MF_01902};
GN Name=dnaE2 {ECO:0000256|HAMAP-Rule:MF_01902};
GN ORFNames=ASD10_17000 {ECO:0000313|EMBL:KQX72651.1};
OS Aeromicrobium sp. Root472D3.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Aeromicrobium.
OX NCBI_TaxID=1736540 {ECO:0000313|EMBL:KQX72651.1, ECO:0000313|Proteomes:UP000050971};
RN [1] {ECO:0000313|EMBL:KQX72651.1, ECO:0000313|Proteomes:UP000050971}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root472D3 {ECO:0000313|EMBL:KQX72651.1,
RC ECO:0000313|Proteomes:UP000050971};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQX72651.1, ECO:0000313|Proteomes:UP000050971}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root472D3 {ECO:0000313|EMBL:KQX72651.1,
RC ECO:0000313|Proteomes:UP000050971};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC translesion synthesis (TLS). It is not the major replicative DNA
CC polymerase. {ECO:0000256|HAMAP-Rule:MF_01902}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632, ECO:0000256|HAMAP-
CC Rule:MF_01902};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01902}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC subfamily. {ECO:0000256|HAMAP-Rule:MF_01902}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQX72651.1}.
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DR EMBL; LMET01000002; KQX72651.1; -; Genomic_DNA.
DR RefSeq; WP_056611700.1; NZ_LMET01000002.1.
DR AlphaFoldDB; A0A0Q7K0B0; -.
DR STRING; 1736540.ASD10_17000; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000050971; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd07431; PHP_PolIIIA; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR HAMAP; MF_01902; DNApol_error_prone; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR023073; DnaE2.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF4; ERROR-PRONE DNA POLYMERASE; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01902};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_01902};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_01902};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW Rule:MF_01902};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|HAMAP-Rule:MF_01902};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695, ECO:0000256|HAMAP-
KW Rule:MF_01902}; Reference proteome {ECO:0000313|Proteomes:UP000050971};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_01902}.
FT DOMAIN 54..124
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1133 AA; 123985 MW; 0D0B193771C2FFC9 CRC64;
MGWNNPDVSW GELERRLSGR PEPDGGDAPG WSRKRRKTGP REIEQPSGPV VPYAELHCHT
HFSFLDGASG PGDLVEESIS LGLHGLAITD HDGFYGAPRF AEEAAKYPAT GLRTVYGAEL
SLGLHAPQNG VADPEGTHLL VLARGVEGYH RLAAAITDAQ LRGDEKGRPV YDLDELAERG
RDHWVVLTGC RKGHVRQALA AGGREAAASA LDLLTQRFGL DGVGVELVDH GFATDSATND
VLADLARDHG LATVATNNVH FARPANGRLA AATAAVRARR SLAEMDGWLP ATGAAHLRSG
AEMQQLFRRY PGAVARTVPL ADELAFDLRA ATPRLPKRGI PEGHTAMSWL RVLADRGIRK
RYANNQQAAR ERIDRELAVI EEKDFPGYFL IVHDIVQFAR GRGILCQGRG SSANSALCYA
LEITAIDSIF FDLPFERFLA TTREEEPDID VDFDSDRREE VIQWVYDQYG RHNAAQVANV
ISYRPRSAIR DASKALGYSV GQQDAWSKQI DGWGPMGSED VEGIPAPVTS LARQMMTAPR
HLGIHSGGMI LTERPIGEVC PIERGRMDKR TVLQWDKDAC EYMGLVKFDL LGLGMLGALD
HTMRIVAEHL GEQWDLDAMP KEEAAVYDML CRADSIGVFQ VESRAQIGTL PRLQPRRAYD
LAIEIALIRP GPIQGGAVHP YIRRAMGKEP VTYPHPILQP VLERTMGVPL FQEQLMQMAI
AIGDCTGDEA DLLRRAMGSK RGIERIESLE DKLFAGMARH GLTDEEAEAI YVKIKSFANF
GFAESHALSF SLLVYASSWL KLHYPAAFLA ALLRNQPMGF YSPQSLTTDA RRHGVTVLRP
DITWSGAQAD LEQLGDAAGA TGRDACLEHE QPPVGRFVRG TPDPTPEHRR DGHFAVRLGL
DEVQGIGSDV ARQIVAARAE RPFADMADVA RRTGLSVAQM ESLATAGAFD GFGITRRQAL
WNAGYVESAD QLDGTAVTAP PPMLPGMSDV EVTMADLWAT RISPETHPVE HLRPLLRREG
ILSVADTVTA EADRRVKVAG LITHRQRPAT ASGVTFLNLE DETGMLNVVC SQALWAHYRV
VGRNAAGMVI RGILERSAEG VVNLVADKLM RIEEVYPEAG RAISPKHRGR DFQ
//