GenomeNet

Database: UniProt
Entry: A0A0Q7K0B0_9ACTN
LinkDB: A0A0Q7K0B0_9ACTN
Original site: A0A0Q7K0B0_9ACTN 
ID   A0A0Q7K0B0_9ACTN        Unreviewed;      1133 AA.
AC   A0A0Q7K0B0;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=Error-prone DNA polymerase {ECO:0000256|HAMAP-Rule:MF_01902};
DE            EC=2.7.7.7 {ECO:0000256|HAMAP-Rule:MF_01902};
GN   Name=dnaE2 {ECO:0000256|HAMAP-Rule:MF_01902};
GN   ORFNames=ASD10_17000 {ECO:0000313|EMBL:KQX72651.1};
OS   Aeromicrobium sp. Root472D3.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Nocardioidaceae; Aeromicrobium.
OX   NCBI_TaxID=1736540 {ECO:0000313|EMBL:KQX72651.1, ECO:0000313|Proteomes:UP000050971};
RN   [1] {ECO:0000313|EMBL:KQX72651.1, ECO:0000313|Proteomes:UP000050971}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root472D3 {ECO:0000313|EMBL:KQX72651.1,
RC   ECO:0000313|Proteomes:UP000050971};
RA   Gilbert D.G.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KQX72651.1, ECO:0000313|Proteomes:UP000050971}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root472D3 {ECO:0000313|EMBL:KQX72651.1,
RC   ECO:0000313|Proteomes:UP000050971};
RA   Schulze-Lefert P.;
RT   "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC       translesion synthesis (TLS). It is not the major replicative DNA
CC       polymerase. {ECO:0000256|HAMAP-Rule:MF_01902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632, ECO:0000256|HAMAP-
CC         Rule:MF_01902};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01902}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily. {ECO:0000256|HAMAP-Rule:MF_01902}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KQX72651.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LMET01000002; KQX72651.1; -; Genomic_DNA.
DR   RefSeq; WP_056611700.1; NZ_LMET01000002.1.
DR   AlphaFoldDB; A0A0Q7K0B0; -.
DR   STRING; 1736540.ASD10_17000; -.
DR   OrthoDB; 9803237at2; -.
DR   Proteomes; UP000050971; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd04485; DnaE_OBF; 1.
DR   CDD; cd07431; PHP_PolIIIA; 1.
DR   Gene3D; 1.10.150.870; -; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   HAMAP; MF_01902; DNApol_error_prone; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR023073; DnaE2.
DR   InterPro; IPR004805; DnaE2/DnaE/PolC.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   NCBIfam; TIGR00594; polc; 1.
DR   PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR32294:SF4; ERROR-PRONE DNA POLYMERASE; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; PHP domain-like; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01902};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW   Rule:MF_01902};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW   Rule:MF_01902};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW   Rule:MF_01902};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW   ECO:0000256|HAMAP-Rule:MF_01902};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695, ECO:0000256|HAMAP-
KW   Rule:MF_01902}; Reference proteome {ECO:0000313|Proteomes:UP000050971};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW   Rule:MF_01902}.
FT   DOMAIN          54..124
FT                   /note="Polymerase/histidinol phosphatase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00481"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..42
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1133 AA;  123985 MW;  0D0B193771C2FFC9 CRC64;
     MGWNNPDVSW GELERRLSGR PEPDGGDAPG WSRKRRKTGP REIEQPSGPV VPYAELHCHT
     HFSFLDGASG PGDLVEESIS LGLHGLAITD HDGFYGAPRF AEEAAKYPAT GLRTVYGAEL
     SLGLHAPQNG VADPEGTHLL VLARGVEGYH RLAAAITDAQ LRGDEKGRPV YDLDELAERG
     RDHWVVLTGC RKGHVRQALA AGGREAAASA LDLLTQRFGL DGVGVELVDH GFATDSATND
     VLADLARDHG LATVATNNVH FARPANGRLA AATAAVRARR SLAEMDGWLP ATGAAHLRSG
     AEMQQLFRRY PGAVARTVPL ADELAFDLRA ATPRLPKRGI PEGHTAMSWL RVLADRGIRK
     RYANNQQAAR ERIDRELAVI EEKDFPGYFL IVHDIVQFAR GRGILCQGRG SSANSALCYA
     LEITAIDSIF FDLPFERFLA TTREEEPDID VDFDSDRREE VIQWVYDQYG RHNAAQVANV
     ISYRPRSAIR DASKALGYSV GQQDAWSKQI DGWGPMGSED VEGIPAPVTS LARQMMTAPR
     HLGIHSGGMI LTERPIGEVC PIERGRMDKR TVLQWDKDAC EYMGLVKFDL LGLGMLGALD
     HTMRIVAEHL GEQWDLDAMP KEEAAVYDML CRADSIGVFQ VESRAQIGTL PRLQPRRAYD
     LAIEIALIRP GPIQGGAVHP YIRRAMGKEP VTYPHPILQP VLERTMGVPL FQEQLMQMAI
     AIGDCTGDEA DLLRRAMGSK RGIERIESLE DKLFAGMARH GLTDEEAEAI YVKIKSFANF
     GFAESHALSF SLLVYASSWL KLHYPAAFLA ALLRNQPMGF YSPQSLTTDA RRHGVTVLRP
     DITWSGAQAD LEQLGDAAGA TGRDACLEHE QPPVGRFVRG TPDPTPEHRR DGHFAVRLGL
     DEVQGIGSDV ARQIVAARAE RPFADMADVA RRTGLSVAQM ESLATAGAFD GFGITRRQAL
     WNAGYVESAD QLDGTAVTAP PPMLPGMSDV EVTMADLWAT RISPETHPVE HLRPLLRREG
     ILSVADTVTA EADRRVKVAG LITHRQRPAT ASGVTFLNLE DETGMLNVVC SQALWAHYRV
     VGRNAAGMVI RGILERSAEG VVNLVADKLM RIEEVYPEAG RAISPKHRGR DFQ
//
DBGET integrated database retrieval system