ID A0A0Q7N1H6_9NOCA Unreviewed; 1690 AA.
AC A0A0Q7N1H6;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:KQY33295.1};
GN ORFNames=ASD42_15595 {ECO:0000313|EMBL:KQY33295.1};
OS Nocardia sp. Root136.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1736458 {ECO:0000313|EMBL:KQY33295.1, ECO:0000313|Proteomes:UP000051507};
RN [1] {ECO:0000313|Proteomes:UP000051507}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root136 {ECO:0000313|Proteomes:UP000051507};
RA Garrido-Oter R., Bai Y.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQY33295.1, ECO:0000313|Proteomes:UP000051507}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root136 {ECO:0000313|EMBL:KQY33295.1,
RC ECO:0000313|Proteomes:UP000051507};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQY33295.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LMFE01000007; KQY33295.1; -; Genomic_DNA.
DR RefSeq; WP_056818437.1; NZ_LMFE01000007.1.
DR STRING; 1736458.ASD42_15595; -.
DR UniPathway; UPA00011; -.
DR Proteomes; UP000051507; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR CDD; cd19540; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 996..1071
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1578..1652
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1088..1109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1690 AA; 181153 MW; 5F11F8F42CBD32DD CRC64;
MSDTEATLSV AERRKLLLQQ KLRERGMSVV QSEPVAVPRI PAGERRPLTP GQRRMWFLQT
RDADDTALNI CVAYRLTGPL DADRLHAAFD TVVARHDILR TTYGADVDGT PFQVFTADAR
ADWSTHDVTE LAESGRDLRV EVLAQRDFAR PFALGTELPL RATLIRTGVD EHVVLFTIHH
ICWDDDSWAI FFAELNAAYR LGAPAADASA ADSQPDTVQF AAIAPTAEPA EDDVAYWRDA
LRPLPEPLEL PGAASAGAGR HARRRTHRLP ADLVTRTEQF AREQAATPFM VLLAGFDALV
HRYTAADDFL VSIPVTDRPV GTEQLIGYFG NTLLLRAGIG GRDDFATLVA GVRDTCTGSF
ARRGVGIDRV VREANPDRVA GRDGMDQLVR LGFSVRKSAD GFAIDGVRST QLELGAASAQ
VPLAFAVVLE ADGSAVVEAE YQTDVLADAL VDQLLVHFGR LLDSALRDPE RRLADLDMLG
DADRAALLDR SHGVLVDEEA TTLVALLESA AAADPEARAL VSDDVELTYA ALHARANRLA
HWLIEQGIGT EDIVGLRLGT SVEFIVAVLA VLKAGGAYLP IDPAYPEDRI EYLVEDANPR
LLLGAVELAA AEDAASELPA TAPTDAERLR PLRPSNLAYV IYTSGSTGKP KGVPVPHNAI
AEHIVCFTAD WNMTPADRLM QSSSVSFDAS LVDIAITLTV GAQLIVPKPN AFRDIRYVAD
LISRRQVTVL HMVPSMLSTF LLLPEISEWQ SLRQIPVGGE ALPGEVADRF ANTLDAELRN
HYGPTEAVVC STHMPVSGPQ GTGVVPIGIP NRNVYTYVLD EALQLVPDGV VGELYLGGEQ
LARGYLDRPA LSAQRFVADP FTPGARLYRS GDLVRRNTFG ELEFVGRADE QVKVRGFRIE
LGEVEAAIAA HPAVAHCVVV VTEDPAIGAM LAAYVVPADG TVDLEQVHAF AASGLPEYMV
PSAFAVIPEI PLTVNGKLDK RALPAATPAV VRTHRAPATA TERKVCALFG ALFSLDEVSA
EDSFFELGGH SLLAARLVAQ VRAEFGVELD VRVVFDSPTP AALAANLVAR FLAEFDIDLD
AVDNDFDDAP AATESETTDT GRPAIGGRAR GERVPLSYSQ LAMWFQYRME GAGSVGNLPL
AMRFDGALDI AALRAALDDV VARHESLRTT FPEHDGVPYQ VVHPAAPVPL PVREIASDQL
TEALAEIADY HFTLDGEPLI RAELLVLDAD THVLSLLVHH IVADHASFGV LLDDLTTAYR
ARCELGVAPN WAALPVQFAD YALWQRELFD QAAPSAFATD QIDYWRAALA DVPEEIAVAH
DRQRPPVLGK RGQVVNFSLP AAVRSGLESL AIRSGATEFM VCQAAVATLL HTLGGGTDIT
LGTPVAARTD PSTTAMIGLF ANMVVLRNDL SNAPTLHDTV LRARNVVLDA NAHQELPIER
LVEALNPRRS RSRNPLFQSM IHFRGADWAP TTLPFASSGE TTVTVLPADF DVSFLDLNLS
LNVTADGGMD VRVVVNADLY DPATAALIAD ALAATLRAFA ETPDLPVADL RVLPAADLER
LLAPPAPIAT SAVATGAATD SDTERTLIAL IEELLEIDEV VGDDNFFALG GDSVISIQWS
ARADALGLPL SPQMVFECAT ITELAAAVDA AAGGATRADE PEQVSHAPMS ASGLESDALS
ALTAAWSAQG
//
