ID A0A0Q8EBI2_9GAMM Unreviewed; 506 AA.
AC A0A0Q8EBI2;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:KRA42991.1};
GN ORFNames=ASD72_13110 {ECO:0000313|EMBL:KRA42991.1};
OS Pseudoxanthomonas sp. Root630.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Pseudoxanthomonas.
OX NCBI_TaxID=1736574 {ECO:0000313|EMBL:KRA42991.1, ECO:0000313|Proteomes:UP000051081};
RN [1] {ECO:0000313|EMBL:KRA42991.1, ECO:0000313|Proteomes:UP000051081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root630 {ECO:0000313|EMBL:KRA42991.1,
RC ECO:0000313|Proteomes:UP000051081};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KRA42991.1, ECO:0000313|Proteomes:UP000051081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root630 {ECO:0000313|EMBL:KRA42991.1,
RC ECO:0000313|Proteomes:UP000051081};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRA42991.1}.
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DR EMBL; LMGY01000017; KRA42991.1; -; Genomic_DNA.
DR RefSeq; WP_056881000.1; NZ_LMGY01000017.1.
DR AlphaFoldDB; A0A0Q8EBI2; -.
DR STRING; 1736574.ASD72_13110; -.
DR OrthoDB; 462203at2; -.
DR Proteomes; UP000051081; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2}.
FT ACT_SITE 80
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 14..17
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 80
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 190
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 338
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 347
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 506 AA; 56757 MW; 5DCCC6EE81C3484E CRC64;
MDGNSIREVV VVGGGSAGWM AASALVRHLD RNCKVRLVES DEIGIIGVGE ATVPHIRTFN
AQALGLDEAE FVRATQGTFK LGIEFRDWAR IGDRYMHGFG TVGHDPGPAA FHHYWLRLLL
AGKNVGDIGS YQLQTAASRE DRFLPGANDV PPTSPLASVA YAYHFDATLY ARYLRGFAEG
QGVERIEGKV VDVELRPEDG FVSAVVMADG RRVEGDLFID CSGFRGLLIE QALKTGYEDW
SHWLPCDRAV AVPCARVGDP TPYTRSTART AGWQWRIPLQ HRTGNGLVYC SRFLSDDEAA
NTLLSNLDGE AQAEPRPLRF VTGKRKQFWN RNVVAVGLAS GFMEPLESTS LLLIQTAILR
LLDMFPRQGI DPGLVARYNE RTHFEYDHIR DFLILHYKAV ERDEPFWREC REMPIPDTLQ
ANIDLFRNSG RFYRDGEEFF ALQSWIQVML GQRIVPSAYS PLVDRLSEAE VEAFVANVRQ
TIDRCVQAMP KHQAFIERHC RAPAVG
//
