ID A0A0Q8ENX4_9GAMM Unreviewed; 509 AA.
AC A0A0Q8ENX4;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:KRA47454.1};
GN ORFNames=ASD72_20255 {ECO:0000313|EMBL:KRA47454.1};
OS Pseudoxanthomonas sp. Root630.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Pseudoxanthomonas.
OX NCBI_TaxID=1736574 {ECO:0000313|EMBL:KRA47454.1, ECO:0000313|Proteomes:UP000051081};
RN [1] {ECO:0000313|EMBL:KRA47454.1, ECO:0000313|Proteomes:UP000051081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root630 {ECO:0000313|EMBL:KRA47454.1,
RC ECO:0000313|Proteomes:UP000051081};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KRA47454.1, ECO:0000313|Proteomes:UP000051081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root630 {ECO:0000313|EMBL:KRA47454.1,
RC ECO:0000313|Proteomes:UP000051081};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRA47454.1}.
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DR EMBL; LMGY01000010; KRA47454.1; -; Genomic_DNA.
DR RefSeq; WP_056879063.1; NZ_LMGY01000010.1.
DR AlphaFoldDB; A0A0Q8ENX4; -.
DR STRING; 1736574.ASD72_20255; -.
DR Proteomes; UP000051081; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2}.
FT ACT_SITE 84
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 19..22
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 84
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 333
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 342
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 346
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 509 AA; 57418 MW; DD1C728DFEEB25B4 CRC64;
MDSPDAPEGH IRKVVIAGGG TAGWLAACAL SHQFRDRLQI TLVESEQIGT VGVGESTVPP
IRTFHRFLQI DEQEFLRAVA GTFKLSISFE NWRRPGDRYI HPFGITGQGT WAAAFHHFWL
DSLRRGMPSE LGDFCLETVA SRGDQFSLQT QPQVNYAYHF DAGLYARFLR RIAEGYGLLR
VEGKIREVRQ HAHDGSVQSL VLEDGQIIEG DLFIDCTGFR GLLIEQTLQT GYEDWNAWLP
SDRAVAVQTE SIGPPVPYTR AIAHEAGWRW HIPLQHRVGC GLVFSSRHMS DDEARAKLLH
DVGAPAIRDP WLVPFRTGRR LKAWNKNVVA LGLASGFIEP LESTSIHLAI SAVVRLVQLF
PFAGIAPSLV ELYNEVSRAE MEHVRDFIIL HYHATQRDEP MWKSCREMPL PESLEIRLRA
WRERAHAWQD PDELFRVDSW THVLLGQGIR PGPPHPLARA LADDDLRRLL DSIRQPIARA
VATMPSQQAF IDRYCKAGAE VWGGRRAPN
//
