ID   A0A0Q8PX48_9ACTN        Unreviewed;       374 AA.
AC   A0A0Q8PX48;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=Inosine-5-monophosphate dehydrogenase {ECO:0000313|EMBL:KRB78095.1};
DE            EC=1.1.1.205 {ECO:0000313|EMBL:KRB78095.1};
GN   ORFNames=ASE01_08015 {ECO:0000313|EMBL:KRB78095.1};
OS   Nocardioides sp. Root190.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Nocardioidaceae; Nocardioides.
OX   NCBI_TaxID=1736488 {ECO:0000313|EMBL:KRB78095.1, ECO:0000313|Proteomes:UP000050886};
RN   [1] {ECO:0000313|EMBL:KRB78095.1, ECO:0000313|Proteomes:UP000050886}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root190 {ECO:0000313|EMBL:KRB78095.1,
RC   ECO:0000313|Proteomes:UP000050886};
RA   Gilbert D.G.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KRB78095.1, ECO:0000313|Proteomes:UP000050886}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root190 {ECO:0000313|EMBL:KRB78095.1,
RC   ECO:0000313|Proteomes:UP000050886};
RA   Schulze-Lefert P.;
RT   "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the IMPDH/GMPR family.
CC       {ECO:0000256|ARBA:ARBA00005502}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRB78095.1}.
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DR   EMBL; LMIA01000008; KRB78095.1; -; Genomic_DNA.
DR   RefSeq; WP_056749820.1; NZ_LMIA01000008.1.
DR   AlphaFoldDB; A0A0Q8PX48; -.
DR   STRING; 1736488.ASE01_08015; -.
DR   OrthoDB; 9805398at2; -.
DR   Proteomes; UP000050886; Unassembled WGS sequence.
DR   GO; GO:0003938; F:IMP dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006164; P:purine nucleotide biosynthetic process; IEA:InterPro.
DR   CDD; cd00381; IMPDH; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR005990; IMP_DH.
DR   InterPro; IPR005992; IMP_DH-rel2.
DR   InterPro; IPR001093; IMP_DH_GMPRt.
DR   NCBIfam; TIGR01304; IMP_DH_rel_2; 1.
DR   PANTHER; PTHR11911:SF111; INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR11911; INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED; 1.
DR   Pfam; PF00478; IMPDH; 1.
DR   SMART; SM01240; IMPDH; 1.
DR   SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000313|EMBL:KRB78095.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050886}.
FT   DOMAIN          15..299
FT                   /note="IMP dehydrogenase/GMP reductase"
FT                   /evidence="ECO:0000259|Pfam:PF00478"
SQ   SEQUENCE   374 AA;  40044 MW;  6AC3DECB41D5944B CRC64;
     MSDIEIGRAK RARRAYSFDD IAIVPSRRTR DPEEVSVDWQ IDAYRFSLPI LAAPMDSVMS
     PRTAIEFGQH GGLGVLNLEG LWTRYDDPEP LLEEVAGLQG VEATRRLQEI YDEPIKPDLI
     TERLREMREA GVTVAGSLSP QRTKEFAKTV TDAGVDLFVI RGTTVSAEHV SSQAEPLNLK
     EFIYELDVPV IVGGCATHQA ALHLMRTGAA GVLVGFGGGA AHTTRTVLGI AVPMASAVAD
     VAAARRDYLD ESGGRYVHVI ADGSIGKSGD LAKAVACGAD AVMVGSPLAR ATDAPGRGFH
     WGAEAHHADL PRGQRVQFDQ VGTIEEILFG PSRVADGTMN LVGALKRSMA TTGYTELKEF
     QRVEVVSGPL TSPT
//