ID   A0A0Q8RHP4_9SPHN        Unreviewed;       334 AA.
AC   A0A0Q8RHP4;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=2-oxoisovalerate dehydrogenase {ECO:0000313|EMBL:KRB93975.1};
GN   ORFNames=ASE22_24810 {ECO:0000313|EMBL:KRB93975.1};
OS   Sphingomonas sp. Root720.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingomonas.
OX   NCBI_TaxID=1736595 {ECO:0000313|EMBL:KRB93975.1, ECO:0000313|Proteomes:UP000051570};
RN   [1] {ECO:0000313|Proteomes:UP000051570}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root720 {ECO:0000313|Proteomes:UP000051570};
RA   Garrido-Oter R., Bai Y.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KRB93975.1, ECO:0000313|Proteomes:UP000051570}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root720 {ECO:0000313|EMBL:KRB93975.1,
RC   ECO:0000313|Proteomes:UP000051570};
RA   Schulze-Lefert P.;
RT   "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRB93975.1}.
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DR   EMBL; LMID01000002; KRB93975.1; -; Genomic_DNA.
DR   RefSeq; WP_056356488.1; NZ_LMID01000002.1.
DR   AlphaFoldDB; A0A0Q8RHP4; -.
DR   STRING; 1736595.ASE22_24810; -.
DR   Proteomes; UP000051570; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   CDD; cd07036; TPP_PYR_E1-PDHc-beta_like; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR033248; Transketolase_C.
DR   PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF02780; Transketolase_C; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000051570}.
FT   DOMAIN          1..176
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   334 AA;  36567 MW;  0D8225E7A246C66C CRC64;
     MNMIQAINSA IDIAMGRDEM IVVLGEDVGY FGGVFKATEG LQKRYGKTRV FDTPISECGI
     IGVAVGMATY GLRPVPEIQF ADYIYPALDQ LVSEAARLRY RSGGEFTAPI TVRTPFGGGI
     FGGQTHSQSP EGIFTHVAGL KTVIPSNPYD AKGLLIAAIE DNDPVIFFEP KRIYNGPFDG
     HHDRPVQPWS KFAESAVPEG YYKVPLGKAN VVREGNDVTV LAYGTMVHVA HSVIKETGVD
     AELIDLRTLV PLDIETVVAS VKKTGRCMVV HEATKTSGFG AELSALVQEH CFHWLEAPVQ
     RVTGWDTPYP HSLEWAYFPG PVRLTEALKR VMQD
//