ID   A0A0Q8ZIN6_9ACTN        Unreviewed;       445 AA.
AC   A0A0Q8ZIN6;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   RecName: Full=L-fuconate dehydratase {ECO:0000256|ARBA:ARBA00013142};
DE            EC=4.2.1.68 {ECO:0000256|ARBA:ARBA00013142};
GN   ORFNames=ASE41_32235 {ECO:0000313|EMBL:KRD06267.1};
OS   Streptomyces sp. Root264.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1736503 {ECO:0000313|EMBL:KRD06267.1, ECO:0000313|Proteomes:UP000051177};
RN   [1] {ECO:0000313|EMBL:KRD06267.1, ECO:0000313|Proteomes:UP000051177}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root264 {ECO:0000313|EMBL:KRD06267.1,
RC   ECO:0000313|Proteomes:UP000051177};
RA   Gilbert D.G.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KRD06267.1, ECO:0000313|Proteomes:UP000051177}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root264 {ECO:0000313|EMBL:KRD06267.1,
RC   ECO:0000313|Proteomes:UP000051177};
RA   Schulze-Lefert P.;
RT   "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O;
CC         Xref=Rhea:RHEA:22772, ChEBI:CHEBI:15377, ChEBI:CHEBI:21291,
CC         ChEBI:CHEBI:37448; EC=4.2.1.68;
CC         Evidence={ECO:0000256|ARBA:ARBA00001737};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRD06267.1}.
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DR   EMBL; LMIZ01000042; KRD06267.1; -; Genomic_DNA.
DR   RefSeq; WP_057582038.1; NZ_LMIZ01000042.1.
DR   AlphaFoldDB; A0A0Q8ZIN6; -.
DR   STRING; 1736503.ASE41_32235; -.
DR   OrthoDB; 9796450at2; -.
DR   Proteomes; UP000051177; Unassembled WGS sequence.
DR   GO; GO:0050023; F:L-fuconate dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009063; P:amino acid catabolic process; IEA:InterPro.
DR   GO; GO:0016052; P:carbohydrate catabolic process; IEA:InterPro.
DR   CDD; cd03324; rTSbeta_L-fuconate_dehydratase; 1.
DR   Gene3D; 3.20.20.120; Enolase-like C-terminal domain; 1.
DR   Gene3D; 3.30.390.10; Enolase-like, N-terminal domain; 1.
DR   InterPro; IPR036849; Enolase-like_C_sf.
DR   InterPro; IPR029017; Enolase-like_N.
DR   InterPro; IPR029065; Enolase_C-like.
DR   InterPro; IPR034610; L-fuconate_dehydratase.
DR   InterPro; IPR018110; Mandel_Rmase/mucon_lact_enz_CS.
DR   InterPro; IPR013342; Mandelate_racemase_C.
DR   InterPro; IPR013341; Mandelate_racemase_N_dom.
DR   InterPro; IPR046945; RHMD-like.
DR   PANTHER; PTHR13794; ENOLASE SUPERFAMILY, MANDELATE RACEMASE; 1.
DR   PANTHER; PTHR13794:SF58; MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1; 1.
DR   Pfam; PF13378; MR_MLE_C; 1.
DR   Pfam; PF02746; MR_MLE_N; 1.
DR   SFLD; SFLDF00111; L-fuconate_dehydratase; 1.
DR   SFLD; SFLDG00179; mandelate_racemase; 1.
DR   SMART; SM00922; MR_MLE; 1.
DR   SUPFAM; SSF51604; Enolase C-terminal domain-like; 1.
DR   SUPFAM; SSF54826; Enolase N-terminal domain-like; 1.
DR   PROSITE; PS00909; MR_MLE_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000051177}.
FT   DOMAIN          203..299
FT                   /note="Mandelate racemase/muconate lactonizing enzyme C-
FT                   terminal"
FT                   /evidence="ECO:0000259|SMART:SM00922"
SQ   SEQUENCE   445 AA;  48314 MW;  8A5579028E745834 CRC64;
     MTATSARITA VDTYDVRFPT SRELDGSDAM NPDPDYSAAY VVLRTDAGDG HEGHGFTFTI
     GRGNDVQVAA IGALRPHIVG RSVQDLCADP GSLSRDLIGD SQLRWLGPEK GVMHMAIGAV
     LNAVWDLAAK REDKPLWQLL AHAEPEWLVS QVDFRYIADA LTPEDALRLL REGRTGIAER
     ETSLLQDGYP GYTTSPGWLG YSDDKLTRLA KQAVADGFTQ IKLKVGADLD DDIRRLRTAR
     AAVGSGIRIA IDANQRWNVD EAIEWTNALA EFDPYWIEEP TSPDDVLGHA AVRRAVAPVK
     VATGEHVQNR IVFKQLLQAG AIDVLQIDAA RVGGVNENLA ILLLAAKFGV PVCPHAGGVG
     LCELVQHLSM FDYLALSGTT ENRVIEFVDH LHEHFTAPVV MRDGRYSAPL APGFSATMRE
     ESIAAYHYPD GAFWAADRAA QGGTA
//