ID   A0A0Q9K2N1_9MICO        Unreviewed;       642 AA.
AC   A0A0Q9K2N1;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (Decyclizing) {ECO:0000313|EMBL:KRE31426.1};
GN   ORFNames=ASG80_03000 {ECO:0000313|EMBL:KRE31426.1};
OS   Agromyces sp. Soil535.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Agromyces.
OX   NCBI_TaxID=1736390 {ECO:0000313|EMBL:KRE31426.1, ECO:0000313|Proteomes:UP000051793};
RN   [1] {ECO:0000313|Proteomes:UP000051793}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Soil535 {ECO:0000313|Proteomes:UP000051793};
RA   Garrido-Oter R., Bai Y.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KRE31426.1, ECO:0000313|Proteomes:UP000051793}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Soil535 {ECO:0000313|EMBL:KRE31426.1,
RC   ECO:0000313|Proteomes:UP000051793};
RA   Schulze-Lefert P.;
RT   "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRE31426.1}.
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DR   EMBL; LMRW01000001; KRE31426.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0Q9K2N1; -.
DR   STRING; 1736390.ASG80_03000; -.
DR   OrthoDB; 3194735at2; -.
DR   Proteomes; UP000051793; Unassembled WGS sequence.
DR   GO; GO:0016823; F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0019310; P:inositol catabolic process; IEA:InterPro.
DR   CDD; cd07035; TPP_PYR_POX_like; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR030817; Myo_inos_IolD.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR045229; TPP_enz.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   NCBIfam; TIGR04377; myo_inos_iolD; 1.
DR   PANTHER; PTHR18968:SF9; 3D-(3,5_4)-TRIHYDROXYCYCLOHEXANE-1,2-DIONE HYDROLASE; 1.
DR   PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:KRE31426.1};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN          7..137
FT                   /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02776"
FT   DOMAIN          225..359
FT                   /note="Thiamine pyrophosphate enzyme central"
FT                   /evidence="ECO:0000259|Pfam:PF00205"
FT   DOMAIN          422..590
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
SQ   SEQUENCE   642 AA;  68770 MW;  B5B5C8D7A667851C CRC64;
     MAATRRMTVS QALIEFLARQ WTVDGDIRER TIPGVFGIFG HGNVAGVGQA LKQLNVDQPE
     LMPYFQARNE QAMVHQSVGY ARMHRRRATF ASAASVGPGA TNMLTGAALA TTNRLPALLL
     PSDTFATRVA DPVLQQLEQP WDIGLTVNDA FRPLSKFFDR VQRPEQLYSI ALGAMRVLTD
     PVETGAVTIA LPEDVQAETL DVPIEFLQDR EWHLRRPLPE HGALARAVAT IRGAERPFIV
     AGGGVLYSGA EDQLRALVGA TGIPVGTTQA GGGSLPWDHP QYLGAVGATG TTAANRLAAE
     ADVVIGIGTR YSDFTTASRT AFRDPSVRFV NINVAAFDAY KHGTQLPVVA DARETLVALA
     AELAGHRVAA GYSERIAHEK SEWDAAVDVA FAPSGRALPG QPEIIGAVQS ATAPEDVIVQ
     AAGSLPGDLH QLWRVRDPLG YHVEYAYSCM GYEIAGGLGV KRGLTAAGDE RDVIVMVGDG
     SYLMLSSELA TVVAEGIKLI VILIQNHGFA SIGHLSETVG SERFGTKYRV YDAEARNFQG
     DRVLPVDLAM NARSYGIDVI EITPGSDAIA DLAAAVAAAK ASDRATFIHV HSDPLVYGPD
     GEGWWDVPVS EVSTLESTQR ARAEYERLRQ AQRPLLGAED AR
//