ID A0A0Q9W0H7_DROVI Unreviewed; 2445 AA.
AC A0A0Q9W0H7;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Uncharacterized protein, isoform J {ECO:0000313|EMBL:KRF78493.1};
GN Name=Dvir\GJ18448 {ECO:0000313|EMBL:KRF78493.1};
GN ORFNames=Dvir_GJ18448 {ECO:0000313|EMBL:KRF78493.1};
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244 {ECO:0000313|EMBL:KRF78493.1, ECO:0000313|Proteomes:UP000008792};
RN [1] {ECO:0000313|EMBL:KRF78493.1, ECO:0000313|Proteomes:UP000008792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SIMILARITY: Belongs to the paxillin family.
CC {ECO:0000256|ARBA:ARBA00005813}.
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DR EMBL; CH940662; KRF78493.1; -; Genomic_DNA.
DR RefSeq; XP_015024314.1; XM_015168828.1.
DR SMR; A0A0Q9W0H7; -.
DR STRING; 7244.A0A0Q9W0H7; -.
DR EnsemblMetazoa; FBtr0441312; FBpp0397849; FBgn0205607.
DR GeneID; 6635934; -.
DR InParanoid; A0A0Q9W0H7; -.
DR OrthoDB; 370973at2759; -.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08368; LIM; 1.
DR CDD; cd09455; LIM1_Enigma_like_1; 1.
DR CDD; cd09461; LIM3_Enigma_like_1; 1.
DR CDD; cd09360; LIM_ALP_like; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 4.
DR InterPro; IPR031847; PDLI1-4/Zasp-like_mid.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR006643; Zasp-like_motif.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24214; PDZ AND LIM DOMAIN PROTEIN ZASP; 1.
DR PANTHER; PTHR24214:SF38; PDZ AND LIM DOMAIN PROTEIN ZASP; 1.
DR Pfam; PF15936; DUF4749; 1.
DR Pfam; PF00412; LIM; 4.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00132; LIM; 4.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00735; ZM; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 3.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 3.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 8..90
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 345..404
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 2330..2389
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 2390..2445
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT REGION 234..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 656..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 820..862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 939..978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 993..1015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1260..1284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1386..1405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1453..1472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1510..1588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1726..1750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1828..1857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1924..2017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2091..2125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..621
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..862
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..978
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1516..1588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1840..1854
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1924..1950
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1951..1969
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1970..2016
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2094..2125
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2445 AA; 263359 MW; 3124EFF1201E8AFC CRC64;
MAQPQLLQIK LSRFDAQPWG FRLQGGVDFA QPLLVQKVNS GSLSEQAGLQ PGDAVIKIND
VDVFNFRHKD AQDIVVRSGN NFVITVQRGG STWRPHVTPT GNLPQANSPY LQTVTKTSLA
HHQPDSQHIG CGYNNSARPF ANGGGDGGVK SIVNKQYNTP VGIYSDESIA ETLSAQAEVL
AGGVLGVNFK KNEKEYQADR SEVLKFLREE ETGGSTPEPH SPANFYWTQS HAIGGNERRT
PLPHSQMQAQ SQSQAGRQDE RIGTNLQQNT LAPAATHRPS LPVAKPHQAE EEQLQQQEQA
DPRIIVMPIC PALQGPDYKA DMDAAAAALA SDAGGVRPLS ASGHPACQLC GVGIVGVFVR
IKDKNLHVEC FKCATCGTSL KNQGYYNFNN KLYCDIHAKL AAQQHPPAGT EGYVPVPIKP
NTKLSANTIS SALSSHGYGS NGYSNGNATP TPAPSEPMPE PDCSISSSSE LPLPPPPSPT
QLLQYEAEEL LLLPQNQQHQ HPTQGSANPL AAQPHPNPDP QQQQQQQQAS KHTRSLSSIS
SGSSQTSSSG VGGCAQLSPS LVASSASTLS LDMEHSPQHS RQASGSCTSL DVGSVVQCPV
DNYTMSMPSP PPPPPPAPAL TPLRSTQNEN DMNTQNKSHN AYNQLLKQYA NKLQQQHPNS
NNTNTTATAT ETTTNRHNNT AKPFAGTTTT ATATTGQLQP HVAALTATLA NQLKFNSHQA
TTTAAAAAPT ANSNPAQSEI MSAHVADEQS AAIYSSYNNN NINNNNMGDS AACTGPCMQT
SANGSDQPFE YVTLTGNVIR SVQPPGKGAG ASYRVNQGYA RPYGASQPPA AAPKSPVPVS
SYPPQQQQQS PRPAGNPYAT LPRSNVGQQE LEEEGLQPQF EEECYEVDVE VALAASRRSH
GSSFSWPPPQ DEGHAAPTAA PLYIAPPETQ HVVVANPVQE VPPLPPGSAT SRLDPQPQVQ
QKSQQAQQLQ PAQAPQWQSY SAPQLTNQLV QQAQLEQESS SDSYTSTSTT TTNTSEEYQR
MYAAQLQAYQ MQQAFEHSGS ELDYQLYYGS AQDVQESASG RRSAQECVDS LSAPLSTYKL
IDMVREVTPS PVPAAATAPA PAGRHVAFND EPEIKELPQL HTELETIPES ATEAEQAAAV
TAWVDDDGQA DDREGLIIDH RCQILESERM FQPTPEINFE IAPVRQRPAP SKIPNPMPKE
WINPMIRVLT TAPEVPFHLV ECPFPKPCDD DFEAAAAAAA AADAAEQTAV VVPPAPSTVA
ASLPTAPSDS YGSEILRESP PRGTRFSQAM ATAPEFPVRF APPATEGVPL PEETVPYMPP
PMDMKPYLRE DYRPKSPFVS ALTTAPERPF EGHFDRDVPI HLIDLPTPKE HLTMGDALCT
APDRGYTPLN PENATQRIDE EQKQQELKKY EFQVLDHEEE LGIQPQPPES VEYYRTEPQQ
QRKSSAFAAM QAFQPSREPL SSSNPNTVTN TPRASIASLS KEQTDLEYQK YCKAQQRNQK
RLDYYHKKEE ELQSQQHSHN QTQMIHQLKQ QQHQQQQQHI ETNSSNLNSN SNSNSLVTAS
NATASSNSSS TVQQSTNSTS TSTSTANSNS KSAYVAKVET HAQVQASSRS TFSATTASNL
TAVNTAYSKF DAHELIEETA DELEHSEVLF PPPSPLSHLK GKAVQSGLHK ADTIPKYQRN
WTVLPTQSPI RTPEPQELRD NVPLAFVDAP KAQAPSTETV HRPIAKVSTG GTTGPAPTAA
RGSIASQGKP MVQPSVPIII EDRSGPVTMA FQSLDEYERP DQSLTPTRPY TPSSVSSMIN
KPAPIIPFYQ TTEKLCFDEC PATHARDYDQ GAASPFPDRA RSPAPGPPPN PLSAIRAPRM
KEPDSTLLPV AAGPRLQAGS ITTGQSYQGQ LLAHSELSTQ SGSQSYSQQP ETLTERKIGN
LSVQQREQSS LLQQQQQSQL QSQTKTQIGN TQIERRRKVT EEFERTQSAK TIEIRTGSHS
QSQAPSQVQL QSQSQVQSQA QSESTERRQS YGRTGYVANQ ARRLSGLEQE ISSLTSQSQA
ISARASTLGE STFPQLRSPT FEDRFPLKPT AAEAMTPNYA AGLVAANKLL GPPPGFKQQQ
QQQSAFKSTS ASVSNSQQQL RSHANSSSLA SASAITSAST SSSASASRSA QASLTKASAI
TTTTNNQACA AYRGAAAAAA TGSSLSAALA KLPNKNASNA AQTAPKPTIA AAAAPPAPAS
FPPNICDLNS NVDGSTGAGG KSGAFGATSA PKRGRGILNK AAGPGVRIPL CNSCNVQIRG
PFITALGRIW CPDHFICVNG NCRRPLQDIG FVEEKGDLYC EYCFEKYLAP TCSKCAGKIK
GDCLNAIGKH FHPECFTCGQ CGKIFGNTPF FLEDGNAYCE ADWNELFTTK CFACGFPVEA
GDRWVEALNH NYHSQCFNCT FCKQNLEGQS FYNKGGRPFC KNHAR
//
