ID A0A0Q9WBF9_DROVI Unreviewed; 2261 AA.
AC A0A0Q9WBF9;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 22-FEB-2023, entry version 36.
DE SubName: Full=Uncharacterized protein, isoform P {ECO:0000313|EMBL:KRF81810.1};
GN Name=Dvir\GJ17604 {ECO:0000313|EMBL:KRF81810.1};
GN ORFNames=Dvir_GJ17604 {ECO:0000313|EMBL:KRF81810.1};
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244 {ECO:0000313|EMBL:KRF81810.1, ECO:0000313|Proteomes:UP000008792};
RN [1] {ECO:0000313|EMBL:KRF81810.1, ECO:0000313|Proteomes:UP000008792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH940649; KRF81810.1; -; Genomic_DNA.
DR RefSeq; XP_015028478.1; XM_015172992.1.
DR SMR; A0A0Q9WBF9; -.
DR EnsemblMetazoa; FBtr0443801; FBpp0400173; FBgn0204773.
DR GeneID; 6628358; -.
DR OrthoDB; 5480873at2759; -.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd11694; DHR2_DOCK_D; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF26; ZIZIMIN, ISOFORM K; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008792}.
FT DOMAIN 277..388
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 789..966
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1800..2229
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 109..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 391..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1544..1567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2261 AA; 256054 MW; E3207B07DE718BDA CRC64;
MERKFTRGLN KPGMAAQLRE SVSQVVRESA VLSKPLVVEP VDFEAFIAKN KTLIQNDPQR
ELLIYPADDV SEIVMPRKQR TNVKSVADRF EPPNEAIVCP LHGSVVLGSN GHSQVSRQSS
LQSNGSLHNG HSSNTSLSNG NGQLSRKSSQ CSNGSASRKT SQESSYESAL SSSTLRSHLA
QPEEVDEYAE EETAAGEDAT DATTLGTRAE CTRFTRQALY TYRAKNHLIH YKYSAYGGNC
HDLPSTSPAE ELLEELYEID ADQDRIDEQM TRSQADTITK QGYLLKGPDS ASDRMFANIG
NKSFKRRYCY LRQEIDGTYM LELHKDEKQG EAKATIVMDF CTEVVQNPKR GRFCFELRMT
AGHKSFTLAA ENEQDFKDWL TKLSSVLAQN KAQEEKRNAS LERQPAANAT PTPQLQPPAM
EPPTFGTLKG LDQSLHPQLM KYGRETDHSI AQARREQRRR LFACYQSHGK AVTNDNVEQY
REHFGTRVLL TCQSLRFRLQ CQPVDLADGA GGEQLCQVEP YITSLALYDA KAGRKLSESF
YFNINEPAAA QMLPNTPVPA SVAGCGIPRR AESDERNAAQ APHSLFDGVS SELLRCPRQQ
FQQLRQCMLS VSAPHADIYL VLRIEKVLQS SIAQAAEPYL KAARDAKLGQ KVHKAAKSCA
QHIGHYRQPF AWAARPLFKA YSHELDVESQ CIFEFNTIYR QELAKLRDEE LLKLLADYRK
PEKLSKLNII PGYMRLQVQL LDQTAPCGLS KSLAPLSTFS ASAKQPLTLE LSEFQSQTER
DAYPYTNFCN HLYVYPLSLQ FDSQKLFSRA RNITVVVELR DGDGEYSKPL KCIYGRPGQD
LLVSQIACPV LHHNVTPTWY EEIKLRLPLG LFPEHHLLFS FYHVSCNLSK KRDAHASFET
PIGYAWLPLL QKNRICLEEQ MLPVAATLPV GYLSIQPLGW GKGNCGPDIQ WIDNQRALYS
VGLRLDSTVL TSDQHLHNFF AHCERLLEGG KTGALPAETE TCKILKAAHA IDMRSLINFL
PTLLNELFTL LVHTQSEEIG LNVIRLLTNI IHQISDEAKR TELLAAYVKY VFHAPYYSQQ
TARLRTVHGE LCRHLPYLLN PNNTDFLIVN KFMRYSAIFF DLIVKSMAQH LLATGRIRML
RNERFPKEYA DRVEQLIKAL VPYITTRYED LGEETQLLNR SLARFVRQCL SYMDRGFVFK
LIRFYMEQFA PGNPRVLHEY KFNFLQEICQ HEHYVPLNLP FVLNPKNRPP ELLQHFTLSE
QFCRQHFLSG LLLQELKSSL NEIGHVRRHA LSIFKDLLAK HELDARYQQR GQLCRIALLY
VPWLGIVMDN LHRIDDLSDS GGCTPNGHVY ADSASYTKRL SCSSSYVFSK DSSTFSSLTS
TPRSKNRLTL HTDQASPCRT SMHIKDHNYL AAIAGTAIGN GISNLSLNSN SDSGDTTTIG
AYTNGETDVA LRNGHNRSVS VTHAQVLARC DKFSAAESKD LLLGFLFIVK HLSQDQMVAW
WQNCNETETL QFLSILDLCL LQFRYVGKKN VVLASDARLQ RPTKAHTLPA RSTPPVLENG
SQEPNTGTLT QTREHLLEDM DLSARSQQAL YESNLATEVG MIILDCLGLY VLQFRQLLAE
SLVLPKLARV YLRFLQLGQS ERLSKHVFAA LRAFINNYSM ALFKGNAMLC GQMVYELLKA
CDSRLVDIRH ESCAVLYLLM RSNFEFSGRK ALTRVHLQVI ISVSQMIGNV IGLNNARFQE
SLSIINSYAN SDKAMKGTGF PLEVKDLTRR VRTVLMATAQ MQAHHMDPER LLELQYSLAN
SYASTPELRH TWLVTMARNH EQNGNLSEAA CCHLHIAALM CEYLRLRGGC TLSWSSTAFG
KISRNIPLDE QGLKLDAGAQ DSQYTEQMLL EQLKQCADFL DRAERFECLG ELYKLILPIY
ERARNFIELA QSYEHLTQAY NKIVEVNRSG KRMLGRFYRV VFYGMMYFEE DHAIEFVYKE
PKLTSLSEIS DRLAKQYKEK FGADVVKLIM DSSPVKVDEL DAKLAYIQVT HVIPFFTKDE
LDQRLNEFEQ NHDVDTFMYE TPFTKSGAAR GSVEEQWKRK TVIKTQYSFP YVLKRIPVKS
REIIELSPIE VAIDEMQSKV SELEEIILPP ADVKKLQLRL QGSVAVTVNA GPLAYAHAFL
DAKVIKNFSL DRVEDLKDVF RDFIGVCHKA LCVNERMISA DQKEYHHVLK ENYEKLCQAL
SELLQDESFQ PLSDDADTAA QRNSMALFNA ISGASHNSST A
//