ID A0A0Q9WBK4_DROVI Unreviewed; 1967 AA.
AC A0A0Q9WBK4;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 28-JUN-2023, entry version 36.
DE SubName: Full=Uncharacterized protein, isoform B {ECO:0000313|EMBL:KRF82061.1};
GN Name=Dvir\GJ19044 {ECO:0000313|EMBL:KRF82061.1};
GN ORFNames=Dvir_GJ19044 {ECO:0000313|EMBL:KRF82061.1};
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244 {ECO:0000313|EMBL:KRF82061.1, ECO:0000313|Proteomes:UP000008792};
RN [1] {ECO:0000313|EMBL:KRF82061.1, ECO:0000313|Proteomes:UP000008792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; CH940651; KRF82061.1; -; Genomic_DNA.
DR RefSeq; XP_015026571.1; XM_015171085.1.
DR SMR; A0A0Q9WBK4; -.
DR EnsemblMetazoa; FBtr0440042; FBpp0396671; FBgn0206189.
DR GeneID; 6632194; -.
DR OrthoDB; 2877710at2759; -.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 12.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 13.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 3.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722:SF10; CUB DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF00057; Ldl_recept_a; 10.
DR Pfam; PF00058; Ldl_recept_b; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00192; LDLa; 13.
DR SMART; SM00135; LY; 9.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR SUPFAM; SSF57424; LDL receptor-like module; 13.
DR SUPFAM; SSF63825; YWTD domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01209; LDLRA_1; 6.
DR PROSITE; PS50068; LDLRA_2; 13.
DR PROSITE; PS51120; LDLRB; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 48..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1809..1830
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 288..329
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 330..366
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 425..469
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 513..556
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 557..599
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 79..91
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 86..104
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 98..113
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 140..155
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 168..180
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 175..193
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 229..244
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1042..1057
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1087..1102
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1111..1123
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1118..1136
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1130..1145
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1151..1163
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1158..1176
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1191..1203
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1198..1216
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1210..1225
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1266..1281
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1305..1320
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1344..1356
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1351..1369
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1967 AA; 217864 MW; E283C147B0A1F7A7 CRC64;
MNKNAVNKTT NCCTKSKYQM AAILRDNHVR TQCHVRGRQW SGKNVSRWSW WLLCLCPAVL
LLVCGEASAA ATGSAHARCD ADQFQCRNGV CILQAKMCDG RSDCTDNTDE LECDYKMCRQ
PHWFPCAQPH GACLAAELIC NGVDNCPGGE DELQCPHRLV FNFGRRNCSQ YEYMCQDHSC
IPLDFMCDGK SDCADNSDET AGCKQAATSC TSGHLCSNGR CLHRKQWLCD GVDDCGDGSD
ESDCENLCQP SMGKFMCRNH GSCLPLSQVC DGQPNCSDGS DESESCRAKP DCSTKQCPPG
ASCHMMPASG AECFCPDGFR LLKFKDKCED INECQERDDL CSQRCENTSG GYRCACDAGY
ELDASNNRTC HALDIGSGKQ SALLLYTTQV TVMGMHLKQQ THQRNHVFSV ATNLSKVIGV
AFDGDHIYWT NIQNEAESIV RARADGSMAE ILLTSGLDAP EDLAVDWLTH NIYFSDNIMR
HIAVCSNDGL SCVVLVTQDV HQPRSLALWP QRGQMFWTDW GNKPMIARAS MDGTRSQPIV
ADNIHWPNGI ALDMHQERIY WVDAKLGSVQ TVRPDGSARR TVLDGMLKHP YGLAVFEDQL
YWSDWGTKSI HACNKFSGKQ HRILARDRII YAVHVYHPAK QPQVPHPCET ARCSHLCLLA
EPDAGGYSCA CPEGMTLSPD GHRCSQTEKK QRLFIGLRQV LLEIEHTSFG RHVVSASHTL
PCRISELAYN SINSTVFIAD NMQRAIFEYA PHPSEQRLTM LVSRNLGNIS SLAFDHLAHN
LYWADMERHV IELLSLRTGH RALVRFFAGD ELPIGLSVMP AEGYMFVALK ARRHTHIDRV
ALSGRGAQTH VFEEDLGDDD IKFAVDYETH TMYWSDSDTS RLSFSNYRQT HAQMFRGKFR
RPYALALVNQ DLFWSELGTP AIYWTHKSNM GPNKRIEIET NPHLGLDGDA ATAATYLHLT
LPVRIPLTAS GRVVASLTPH PCQQANGGCS HVCVSAGQFD RACLCPAGFV YRDAFNRSCT
EALDCEFRCR SSGECLTMAH RCNGHQDCAD SSDESDCDTI KRVKVKCGLT QFTCHDGERC
LDKSKRCDGH KDCDDNSDEL HCAQFDKTKL CHAHQLACDN GKCVDYTLVC DGKNDCGDNS
DELRCKEAAS CDRGMFQCSS GSCIASSWEC DGRIDCSDAS DEHDKCGQRQ CPAQMHRCLL
GQCLDAQLVC DGHNDCGDLS DELNCEQRKG AAATGAAVNI SCGTLTTPMY QCASNMQLCL
DMEVRCNGSA ECPRGEDEAD CGELCSIYEF QCRDSKQCIR QEFRCDKERD CADGSDEEHC
EQYANGNETS THLAGESVSA RRACKPHLFD CHDGECVDMS HVCNGFADCT NGNDEGPQCT
SACSKPLCQH RCQATPAGAV CTCLDGYRLA SDQRSCVDID ECAVPAEQQP CAQLCENTPG
SYQCQCHADF MLSQDRSSCK SIQSGAPLLF TSYNEVRNLS AHPVTLSVAW SANDTAISGF
DVDMRRQLGY FSSEEQNIIY RVNLRDRSQM TALALRSPSK MAVEWTTGNV YVISGRTPQQ
ISVCNFEAKM CGSILQMLSR FSLKALAVDA HKARLFYVAI RSESFGQPIT QLHMARLDGS
RRELLLRKQR SYVTAIATDP HQQLLYFVDL HSHTLEMISY KGRGSGKQRE AHVLLQKSNA
LLQPTGLSIY ENQAHIVNMG AKEAVSCQLY GQRTCKAINL NVLNAQDIIV AGWSRQPAAT
KNPCQHAHCA GMCVLGDYGY ECMCGDAVVP ETQQCPHGST NELDINSLLS SEQRSDGSGD
GGGGGGSRVV WLLAILLLIG VVGTGIGILW QRWPANRFRR SATKWTWQAK AAVAPVAQAR
AQAQASTAAL EPQPPLLRRG AKRFTLAYPK SCRDYYNKGK HRTANWLQKF RSKTHDSQAK
YSRWSMDGEV VECRTSWYQA LAMMPPQPDT TGEITQAMMC MHGLYHR
//