ID A0A0Q9WEZ6_DROVI Unreviewed; 2778 AA.
AC A0A0Q9WEZ6;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=Uncharacterized protein, isoform F {ECO:0000313|EMBL:KRF83112.1};
GN Name=Dvir\GJ23976 {ECO:0000313|EMBL:KRF83112.1};
GN ORFNames=Dvir_GJ23976 {ECO:0000313|EMBL:KRF83112.1};
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244 {ECO:0000313|EMBL:KRF83112.1, ECO:0000313|Proteomes:UP000008792};
RN [1] {ECO:0000313|EMBL:KRF83112.1, ECO:0000313|Proteomes:UP000008792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
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DR EMBL; CH940650; KRF83112.1; -; Genomic_DNA.
DR RefSeq; XP_015027499.1; XM_015172013.1.
DR SMR; A0A0Q9WEZ6; -.
DR EnsemblMetazoa; FBtr0438996; FBpp0395702; FBgn0211063.
DR GeneID; 6629618; -.
DR eggNOG; KOG2060; Eukaryota.
DR eggNOG; KOG3799; Eukaryota.
DR OrthoDB; 2891597at2759; -.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd04031; C2A_RIM1alpha; 1.
DR CDD; cd04028; C2B_RIM1alpha; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR010911; Rab_BD.
DR InterPro; IPR039032; Rim-like.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12157:SF21; RAB3 INTERACTING MOLECULE, ISOFORM F; 1.
DR PANTHER; PTHR12157; REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF17820; PDZ_6; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50916; RABBD; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 4..130
FT /note="RabBD"
FT /evidence="ECO:0000259|PROSITE:PS50916"
FT DOMAIN 68..118
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 808..885
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1103..1224
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 2635..2753
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 142..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 527..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 586..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 642..661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 751..800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 906..930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 990..1032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1049..1087
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1248..1316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1359..1420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1439..1481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1494..1519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2114..2247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2294..2361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2411..2441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2468..2599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 19..56
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 157..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..545
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..800
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1032
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1252..1295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1298..1312
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1360..1382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1439..1479
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2187..2245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2411..2438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2485..2512
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2521..2536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2778 AA; 300768 MW; 298644CFC836755E CRC64;
MDEMPDLSHL TPHERMQIEN VLMRQKQEEE KQNEIMRRKQ DEVVTLEMQI RQRSEQQKKA
GVELDATCHI CLKTKFADGV GHICHYCNIR CCARCGGKVT LRSNKVIWVC ILCRKKQELL
SKTGQWINKT AVQQDGFIRR IEPDGSSDIS QQAIVDPHDT TDKRPKLERT RSAAEKENLP
MQRAGSMLRR QYSQQEQPTN RRLSVSDSGM DPMSPGQQQQ RQRMQPMTPQ QAQQYQLQQQ
QGYGQQHSQR SGAYPEDDPR YYQGELDGLM RQHPHLAHPS QLQQQQAHQQ QQQQQQQQQQ
HQQQQHHMPQ QQQRPQPQQQ QYNARQQHPQ QQNQQQQHQQ QQQQQQQQHQ QQQSYQGIAT
HAQIHQQPSQ VGGGYQKPPP LTRNLTISGG HAMDATSYNQ QQQQQHQQQQ RRALAGAQYA
SQQQRSFSSS EEEFQNHLMA AEAQVQGHTP NAGSDYDGGR LQVRTDPWRQ QRSLNERDLL
TVGGSYSSSD VRLLGHTNQR LYASADQRDR YELQLQHRER LEQYPLTRTA RLDVQQRNSL
NRSNHERAPG AGGAGVGPGA ASGVGVGVGI GVGGGAFRRA PPLSAANGYQ GSSSSSTSSS
YYPQSHSKPQ IVIGGGAGTG TAYERGAMSA TADGARGNLS RERGLLSAGG GGGSSSLSST
EAAYWDEPAG STSSSSAAQD SRRFTERRIK KTVRFDAHDD ESLLGPAGTG TATGGTGTLP
PVTTILPSTA VDVGTATLLT SAKLAQPLDG DWSRWDAERQ GSQDSATKDS GIDTSSTFTS
SEDSNRGEGP KNPVNWHTSA DNTRMIGHMI LRKYYDGEDI LGLKVNGGQP IGIGGPCGAI
VEKVKRGSVA DLEGCIRPGD EIIEWNRRSL HNRSADEVYD IIDDSRLDAQ VELVVCRPLL
LPTGASSVDS GGSSNVSPSS ACSGSGSSIT RRSSANFPHS GLASSMAGSA VVSSGGRYIQ
RKAPGIEALE LHREKPSVLI TSPGSPDLLI SGSANGLRHR GAGTGSSAQQ AQRLEASHSH
SSSGSGSSST SSATLQAAVA AAAAAASGGQ HSTTTAGHHH HCYPAAASPP SHAHAHPHSY
SHPHTHSHVP HYGMGVTTQP IPVEGRLQLK LGYDQNTLQL IVTLVCATGL SLRQSGAGRN
PYAKVFLLPD RSQKSKRRTK TVGTTCEPRW GQTFLYSGLR RCDLNGRLLE VTLWDYVRYG
ANDFIGEVVI DLAHHVLDDE AEWYQLQPHQ DNSHLLRDEG SDVDGLILTP TDHLSPPSTM
SRLSDSDTTS ECDIDGTTPG ASISSMGSST SPPLLELDLN ERRSRRDMSP QGRKRVAGMV
ARDYRTVSGI GQSYHNQASA TGYYRRGVGN GIGATIGPGG MSLSQRSHSA APSDNYHSVG
GSGSGVHQGH PGSGYGYRSS SPRRGSLSPP DDRYIDYPVL PIHGSPNAAA YAGGGSTAAA
AQATQQHRFQ SRSATATPTG SPKKRQLPQV PQSSRSAMLR DRLGQDFDER LASGSRFGRH
RTRQPHHQAT YRSTGMGGWE RHYTGLSDSD LQSMDTRMRP RHSLSPDKDF MAEFGDSDME
SVVSVTSSAF STQSERPRTS RGLSFSRNWR NLFGAQNSLL SGAVGGPVTG LKVYPVEHHR
ANTIEVDDCD YLSSGGTQQL LLLEQLEQLQ QLAALAAADS PPNTALLGLS GAAPIAATTT
LPMPTQHVLV TDTSSGELVE QFFVEPALVA EETSPLEPHE PHFHSHCDYY SPHLPNTFIP
PPGTANIYQR RHNGRQLAPA TATATATATT HANAHSHAYA LPLPLPSFEQ FKRYTTPVMN
LFRSSTTAAP AHDHAHAHTV SSSPSSYVGY VRDHLDNSCS HCQNGSQPVV LSTNTALATP
GLAIGACTDP CCLADAHPHP QHQPITYPYS AEQLLRRPSL SMYQPSSSEP SLPTMDPAMC
GECVDQHFLG GLTGPQLNLG IVPTYHVHTP TPTAHRRAKS QLTPHPPLPT QFVLRLSRQL
SEDALVAAVP IAEATARAQP TSILKKPKLE RRRMFHEGQS RSLDYDDLHT KSWGRRRIRY
EDEVAPHEIL TYPTEGQLPS SRRYGSETNI RQSYMGANVD AANPLSHSHF LVTDDKIVTI
TYDSDVGWTR RGVAPSLFRG PHRRGPDARN HMSLDLQRTS QQKLYGPAAP YMKRRRNLPH
PPSAQNAHNF SPMEAGAGVG NENGIGVGGG AQNSTYNHNQ NSSHNTNHNS QAASSFSVSQ
SHNNNNNNNY NQQQQQQQQS ARQKGKEGIA MNGLMASASE QLTKSSSGSG GATTAAAAAA
GNIVCDGNNA NNASSSSFAN PPQQHHGVAN QPITTTNASP NKRAPSLIHN TTTTNDANNL
THDATSTNPT QQQQQQQQQT PNTCTNLITN TTTTTNTSSN ATNAAATTTT TTTTTITLTT
ATTATTTATN TTTKTTTNTN NTNEPNATTT TANTNPDTDA DADADAPLDV IDWDAIDAML
DDDFSEYDKE KNGINEPGGA KSVEGGAETE EKVDGSLSDT TTDRKKCGTV DQERSPKGGS
GMGKKSNSTS QLSATGRKRR MGFGKKGKNS FTVHRSEEVL PGDITREMRS VGGAGVGGLS
RGSSSEADPV EQFFGDGAGG ERFSPSLRND GALNEFVDGL GPGQLVGRQV LGAPSLGDIQ
LSLCHQKGFL EVEVIRARGL QQKPSSKMLP APYVKVYLVS GKRCIDKMKT STARRTLDPL
YQQQLVFKQS YTGCVLQVTV WGDYGRIEKK VFMGVAQIML DDLNLSNIVI GWYKLFGTTS
LGRPIVWAGE SIMEEQGE
//
