ID A0A0Q9WSI7_DROVI Unreviewed; 1959 AA.
AC A0A0Q9WSI7;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Uncharacterized protein, isoform C {ECO:0000313|EMBL:KRF85223.1};
GN Name=Dvir\GJ14080 {ECO:0000313|EMBL:KRF85223.1};
GN ORFNames=Dvir_GJ14080 {ECO:0000313|EMBL:KRF85223.1};
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244 {ECO:0000313|EMBL:KRF85223.1, ECO:0000313|Proteomes:UP000008792};
RN [1] {ECO:0000313|EMBL:KRF85223.1, ECO:0000313|Proteomes:UP000008792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; CH940647; KRF85223.1; -; Genomic_DNA.
DR RefSeq; XP_015031566.1; XM_015176080.1.
DR SMR; A0A0Q9WSI7; -.
DR EnsemblMetazoa; FBtr0444661; FBpp0400981; FBgn0201298.
DR eggNOG; KOG4292; Eukaryota.
DR OrthoDB; 2917265at2759; -.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00041; CUB; 10.
DR CDD; cd00054; EGF_CA; 6.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 10.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR47761:SF2; C-TYPE LECTIN; 1.
DR PANTHER; PTHR47761; C-TYPE LECTIN-RELATED; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 10.
DR Pfam; PF00008; EGF; 3.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF12661; hEGF; 1.
DR SMART; SM00042; CUB; 10.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 6.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 12.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01180; CUB; 10.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..1959
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006387091"
FT DOMAIN 158..194
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 196..238
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 240..282
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 294..333
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 427..463
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 464..501
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 507..623
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 627..744
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 750..861
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 862..987
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1099..1212
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1216..1325
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1326..1440
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1442..1553
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1557..1672
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1776..1886
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 184..193
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 228..237
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 253..270
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 453..462
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 491..500
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 507..534
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 862..889
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 1959 AA; 216214 MW; E43D20317FE489F6 CRC64;
MHIDKANLVT SLYLCLLALC LHLPRIKAAG ARLQPQLHGS EDGTLLFEAA TDQNITFRLM
GEAATLLLND VDVVSLLQGR QRAAAAQSAA TRREPLSLDA LKEQFRSVQR DLLRLARWLS
NMQNGTRRYG PTQRVLRRDL QRVQVIANTL TSLETNLAKD ECLSTPCKNG GTCYDAYNAF
YCVCAAGWQG STCEDDVNEC TDFAGTDLSV CKNDAQCINT PGSYRCFCRN GFSGEHCRLR
QHACLTNQSA ELCGSHGTCL PANNAGGYVC ICDPGWTWAD TNVSVANSSP CTRDVDECAP
DVNPCHNECI NLPGSYRCGA CPPGYTGDGR HCRDINECAD GNNGGCSQRP LVSCINTEGS
FRCGRCPPGW TGDGRVCNEA KSNLCNDQLI CDLRAQCEYI SGTVVCSCGA GFYGHGYGAD
GCTEDSSRKP CDDHRCLNNG TCVLSGRGTS CICQPGYTGA VCAEADACHP NPCQNGGTCR
LLPGNQHQCM CPVGYTGSSC SHVRSYCGLV LRNETGTLQF PPGDNSGYQP NERCAFIIRS
RRGMVLNVTF GMFELQPSAD CSADFVQLHD GSSLTARLIG RFCGSGLPLG NGSVVSTQEQ
LFFWFRSDNE TQARGFNLTW KSQPLVCGED LTLALGESGI LRSPSYPGKA RPGLYCRWHL
TAPYGTRWLL RFYEITLGNS IGNPSLNCSD GDSLSVWDAD RQLYMACQSA QPAPLHSSSN
LLHIHFHTDQ YRTDSSFQLH YEVVTGHPGC GGTFTEPSGL ISGHMNAELC LYLIEQPNGT
RIELNFQRIN LLRAEDCSLQ KLEIFDGRSD EQPLLGRYCG QPEESELQPL ISSSNVVLVR
YAYALPGFEL HKSFVLRYNR ACTGIYSDAE GGIITSPNYP NPYFENLNCT YYLRGPTNTV
VRINITDLSL SETQPPAPES DELSIQAEDQ LSYLDVYLTR NESEKQRFVK NLTNLLLIST
NNQARLVFHS ASNPQRGRGL HVEYTFIENA YCGGVLSTPS GAVDFYINHQ SCQWIIEAPG
RKHLQMRCMT LFGTFNLNVY DNSTGGEGKQ LHSYHINEAH TLFEFDEYTD SNLLTIIATS
SPHTAYAVTF KYEPIKQECG ATNTARYGNI KSPNWPLKYG SSENCTWLIR APLGSRIELI
VKNFTLEASS DACYADYLEI RNGDQPTSPL IGRYCGDRIP PRLPSYGNVL YVHFESDYAV
EEAGFHLVWE TAATGCGGKL SSPVGAIHSP HSVAGNSGAV ACDWQISVAQ GSTVRLQLQS
QDDVCNGQLT IYDGPTTRSN QLRLNCSSAG QQMNLEASSN RVLVRYNVDN ETSDGIDFVL
DYTTNCRVRL EQMRGAIETP NFPDNYPTNT NCEWDIRGGA SSNRIQLAFS HLAVERTDSD
NCIFDYVLLG DYRDDQLISE RRLCSAKDLD ITSVGNRLLI RFNSDASEQE QGFRAEYKRL
GCGDELQGPG GTFETPNAPY SVGLDCDWLI TVPEGYQIRL LLRELHIETP QGDCSQDVLT
VLPGGNSSQV LLRSCQVESN VQTLISPANE LRVRFQSSPQ RARKYIKASY VMVPAVCGGY
MSLSSGTITS PGFYEQGHDI YDKDVECVWT LETADTHGFL LHFEPFNLTD SSNCSVAWLE
LSSSKVRNSE QFIERYCGDK PPSAVIVQNR LRLHFKVSSG FWGKFELHYQ RICGGGRIAS
EGYLRSRLDE NCYWTIFGPE GSKISLNINQ LECPRCTAAD GNCTAGLRIL NDEDEVQYYN
LCQEHPANLL LPTNKVRIQS NGIAMEAQYT TIENSCGGNI TSVRGTLSSP SYPDSYPANV
ECVWLIEPRA GNAIELNFEA MDIAKSEHCN GDFLEVRAGI LGAVLGLYCG MELPAEPLLV
RTKLWLKFRS QLGSSANGFK LRWSYVHDNE LTEGTNGTIE SPSTAAVRGD DQPYSWRIFT
ERERVLALDF KEYNTGLLIR TWHSCSCLMA STILRCPSA
//
