ID A0A0Q9WUR4_DROVI Unreviewed; 8858 AA.
AC A0A0Q9WUR4;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Uncharacterized protein, isoform F {ECO:0000313|EMBL:KRF85409.1};
GN Name=Dvir\GJ15760 {ECO:0000313|EMBL:KRF85409.1};
GN ORFNames=Dvir_GJ15760 {ECO:0000313|EMBL:KRF85409.1};
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244 {ECO:0000313|EMBL:KRF85409.1, ECO:0000313|Proteomes:UP000008792};
RN [1] {ECO:0000313|EMBL:KRF85409.1, ECO:0000313|Proteomes:UP000008792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00006692}.
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DR EMBL; CH940665; KRF85409.1; -; Genomic_DNA.
DR RefSeq; XP_015024040.1; XM_015168554.1.
DR EnsemblMetazoa; FBtr0435792; FBpp0392736; FBgn0202948.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR CDD; cd00063; FN3; 39.
DR CDD; cd00096; Ig; 3.
DR CDD; cd05748; Ig_Titin_like; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 78.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR14340; MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3; 1.
DR PANTHER; PTHR14340:SF21; MYOSIN BINDING PROTEIN C2; 1.
DR Pfam; PF00041; fn3; 38.
DR Pfam; PF07679; I-set; 35.
DR Pfam; PF00069; Pkinase; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 39.
DR SMART; SM00409; IG; 38.
DR SMART; SM00408; IGc2; 31.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 21.
DR SUPFAM; SSF48726; Immunoglobulin; 39.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50853; FN3; 39.
DR PROSITE; PS50835; IG_LIKE; 31.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 9..102
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 122..212
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 231..324
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 338..429
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 441..534
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 546..638
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 643..731
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 749..838
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1645..1723
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1740..1824
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2018..2115
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2118..2216
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2220..2310
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2317..2413
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2419..2514
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2616..2713
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2719..2813
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2818..2910
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2914..3013
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3019..3114
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3118..3207
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3215..3309
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3316..3411
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3415..3505
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3513..3606
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3612..3707
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3711..3800
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3808..3901
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3907..4002
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4006..4094
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4101..4195
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4201..4300
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4304..4393
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4401..4494
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4497..4595
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4599..4690
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4696..4789
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4795..4889
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4892..4982
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4990..5085
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5091..5185
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5190..5279
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5287..5380
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5386..5480
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5445..5573
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5580..5674
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5680..5775
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5875..5972
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5978..6073
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6077..6166
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 6175..6269
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6275..6368
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6375..6470
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6464..6561
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 6570..6664
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6670..6765
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6866..6960
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6966..7061
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7067..7162
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7168..7258
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 7361..7456
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7462..7557
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7557..7651
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 7656..7749
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 7754..7847
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7904..8159
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 8227..8315
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 8352..8439
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 8557..8645
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 8665..8753
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 8764..8852
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 839..863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1047..1202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1217..1411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3097..3118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3590..3620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3886..3912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5066..5096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5362..5391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6351..6398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6453..6478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6650..6674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8468..8542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1047..1078
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1090..1106
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1122..1202
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1244..1289
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1334..1351
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1371..1393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5362..5378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8474..8541
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 7933
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 8858 AA; 990793 MW; D87056B27FB3B96F CRC64;
MGVAEDFAPS FVKKPQLHQE DDGNRLIFEC QLVSSPKPDI EWFRSDNKLT EDARTKFKIQ
PIGDNKFTVV LELDDVVETD AGLYKVKAKN KSGEVSASIN LNFTLGKFSL LEDLRQIDGF
APTFAKKPAI RQEEDGKRLL FECRVNADPL PNITWFHNGT TVQESPRHRL TIDKDVHSYF
ATLEIQNVTV EDAGKYKVNA KNELGESNAT ISLNFDSDEA PVPESTDGIK PTFTERPVIR
QSEDGGNVTF ECRCVGDPTP TVTWSHGETV LSEGKRYKMS LTLDQKLYHM ARLEISSVVS
SDQGEYRAQA KNKHGSGVAT INLNFESGSK KIPDGKSPRF PKKPTIRQEE DILIMECILE
AHPVPDITWY CSDKQILDNQ RTKMTRKAIT KDSYVLTLEI QYPTKDDGGN YRCNAINMFG
ESNANIALNF QGANDANGFA PSFIEKPRII PNETGTLITM KCKCKAKPEP TVKWYRGQDL
VEKSKKIKIN STVIAEDTYE LTLEIKDPGA TDGGTYRCNV KNEYGESNAN LNLNIEAEPE
PEGEGPTFIE KPRIISENNG KLVIMECKVK ADPKPDIVWF RNGEVIKESN KLKIFMEQRG
DQYYIKLELI DPQLEDSGLY KCNIKNSLGE LNANLTLNIE IVPVIKDKPK IIKIIKKRTV
VIECVVVSKF EPKCTWYKET NTVAESKRHV YLVEKTKEGE FAVKLEINEV EDSDKGAYKL
VASNEKGEAV SQVVNLVDIP EEERKPSKPD IARKLVDQKV TESKTFELII SLKNSDRKCK
VEWYKGSTLI RETKDITTTF DGTTARLTFS SAKSEHTSNY KVVVSNELGK DESTCKVTVE
KKDKKKDEKS EQDKEKEEAE KKRKVIETKT KTKTKEISQQ EDLAEREQQT NQISLKVQNN
QIVNQQISVT SYEQAYIQEQ QSTLIVQQTK QTEQQQVSET HVSYSSEVQK AHHQELLVQE
HSSPKVQAKV SSTCTIETQP TSGLTIYQIP KLKSRKTSEP PVNASESKEK NIFGVKLTPV
RHVLNDEEPA EQIGLKKVER RASIVSVKEE SKSETRRKSI IKSHEQTSEE DTKTVSRRSS
FAVEENVSES RRSSVVDKKA LEQVESKKIE ANNNPQAIKE EIPKLKPADK RRIPKAVEEQ
KPAEELPKLR KTSIAKPKEE PIPEAAKPKA KGKLKAKPKY EELPEIPDYE RPALEKYEKS
DFTPSDFARE LEIPNKMEKP ALETAKKPAE IVPQKNGLPK KTEVVEQPAE EPKTIKLGKG
KLPDDEDTRD GATLKPVIVE PEEEKPKVPK MQPPAPGDPP KIEVIREKRP SLAPEPPSRR
GSLVPPADTG RRPSLIINDE KKLRPGEVMD TRLLRPGEVG EGQQKQQRPG EMGDTKQRRR
PSIDVRRPSV QDLEDLINKP STPLRDIGDG GPPTIIDVQE SYSAVEDSTA YLTVGVEGNP
APTFKFYKGV TEIIEGGRYK FLTDGQTNTI TLCMRKCKPN DEGKYKVVVS NIHGEDSAEM
QLYVSDSSGM DFRAMLKKRR YQKWDKEEQD PNWGDLKETE KPLPALKKVE RKVESFLSPL
IDQFAKEGKD KKVVFEARFS KPNCKPKWLF RKDEVFTGSK FKFKQENDTY QLIISTPKVE
DSGKYTIEIG GVSSTAFLNV EEADPTYTFT KPLKKKLEGF TRHETTLECS VSSSMANVSW
FKDNQKLESD DPRYLISKDI NGNLKLIIKE SVLEDAGQYR CQLDKQPDKT ECALKIVEYP
YKFVKVLKSQ QCVEKDTVTL ACEIDDAQGD VQWFRNGEEI KPDKRMQVVK DGRKRKLIIK
DCKVTDAGQF KCTTNADQTD AEIIINYQNR FNKKLKDTDA VEREKLVLDV ELQDQTAPCD
WKFNGEPIVP NERIEIKNLG GGKHQLVFNG LDLSDAGEIT CESGQLTSTC KLSVRKGESR
PNIDCPDEFA EPISAPVVIE VPYKVSGTKQ TPVEGKLIKD GKPLPLKDVE VAITDDKITF
KIKKPSRDLS GPYQIKISNA QGEDTKDVNI ICQDVPQPPQ DVDVTDVYQT SCVVNFKPPT
DDGGSPITKY VIERQDLSKK QGWEPVAEVL PNEPRLKKID DLVPKKQYRF RIRAVNKLGP
SDPATFKNSI LAKDPWDEPG KPKAVDLTDW DKDHADLKWE APDSDGGDPI TSYVIEYKEK
FSNDWVPGRE VPGDARTGTV ENLKEGQQYE FRVRAVNRAG PGEPSDKTKP IIAKCRFVKP
FLVGDGLKNI TVKKGQTIRY DIKYDGEPEP VASWIKSNEP LKFDNQRICL EQLERNSSIT
IKKSVRNDTG KYKLVLTNSS GTIESEAQVV VLDRPLAPGG PFEPEEVRAH RIKMKWKRPP
DDGGCEITGY ALERMDEETG RWIPSGEVGP DETSFDFKGL TPNKKYKFRV KAINKEGESE
PLETTDAILA KNPYDPPSPP SQPVIDDYDN KSVSLKWKRP PSDGGRPVTH YVVEFKDKFS
PTWSEVAKTE DPTPECKVEG LKEKMVYQFR VRAVNKAGPS EPSQPTDNHL CKHKNLKPQI
DRSTFKRVTI KSGRTHKWSV DITGEPVPEL HWSWRDDIAL TTGDRISIEN VDYHTDFVIM
NAKRQDSGFY SLKAENRNGV DRETVELVVL GKPSSPKGPL AVSDVTATGC KLQWKKPEDD
GGIPIKEYVV EKMDTATGKW VRVGRSPGEK EPPSFDVTGL NPGSEYMFRV SAVNEEGESE
PLTTLVGVVA KDPFDEPNKP GTPEVIDYDN QSISLKWTPP KNDGGAPIQK YIIEKKDKNK
PDWEKALEIP GDQLEAAVAG LQEYGEYQFR VIAVNKAGPS PPSDASVPQV AKYKKLKPRI
DRSNLKPLLI RAGKPIKYDV NVRGEPVPTI TWYQNDKELK PEDLPTNCEI QNIPHNTKIS
IIDTVRKHTG TYKIRAVNEH GEDEADVEVN VLAPPGKPKG PLAVKDITKD SCKLKWQKPD
DDGGKPITAY QVEKFDKKQG RWVPVGRASG NDTEFDVKGL QEGHEYQFRV KAINEEGESE
PLETDGSILA KNPYDAASKP GTPKIDDYNE HMVKLKWDAP KHDGGAPITG YIIEKKDKFS
PIWDEVFTTN TPAPEAIVDG LTEGNVYQFR VRAINKAGTS EPSDPTEPHL AKPRNLKPSI
NREKMKPVKV RAGQTVKFDV DVKGEPAPTL TWSFKEKEVT PSGQLRLDND DYNTKLVLLD
TTRKDTGVYK LKAENINGVD EAEVEVIILD KPAKPEGPLE VSDIHKEGCK LKWKKPKDDG
GVPLSGYAIE KMDTATGKWV PCGTVDPEKT EFDVKGLDPN HRYQFRVRAL NEEGESEPLE
TESAITAKNP FDISAPPGLP ELEDWDEHHV KLKWEPPIRD GGTPITNYII EVMDKDSGEF
VKASETEGPI CKGVVKKLEE GQQYKFRVRA VNKAGPSEPS EQTNWHTAKP RFLKPHIDRT
NLKPVIVKAG LSISLDINVK GEPAPKVEWL FNGLPVISDE EGIKIDNVDY NTKFFVMRAK
RPQSGKYTIK ATNEVGEDVA DLDVTVLGKP GKPKGPLEVN DMTKHSCKLK WEKPEDDGGA
PIDYYEIEKL DPHTGQWLPC GKSAEPEAKV IGLHEGKPYK FRVRAVNKEG ESEDLETDKP
VIAKNPFDEP DKPGRPEPTN WDKDFVDLAW DPPKNDGGAP IQKYIIQMRD KSGRAWVDAA
TVPSDKTKGT VTAVEEGHEY EFRVVAINKA GPSEPSDVSK SVVAKPRFLK PHIDRKNLQK
KIMRSGQMLH MDAAVKAEPP AKITWTYNGA EIKTSDKIKI ENEEYKTTFI MPKVRRADKG
TYIVTAKNDS GVDTVDVELE VLCKPSKPKG PLAVSDVTAE SVHLKWHKPD DDGGEPIEHY
VVERMDTETG RWVPVLTTKT PEADVTGLTE GKEYLFRVKA VNAEGESEPL VTDTPVTAKN
PYDAADTPGK PQITDWSANH ADLKWRAPDD DGGAPITGYI IEKKDNNTGK WQKVLETNTP
DCKTRVNDLI EGTKYQFRVK AVNKAGQSKP SEASDQMSAK DRFAAPKIDR TNIKDITVKA
GQHIRFDIKV SGEPPPSKTW FHNKARIDDD DYNIDIESYR TKLAVPFAKR LHSGKYTIKA
ENESGHDEAS FEVTVLDKPA PPEGPLRVTD VHKEGCKLKW NPPMDDGGLP IEHYVVEKMD
VETGRWLPSG RFKEPFAELN NLEPGHEYKF RVLAVNTEGE SEPLVGEHSI VAKNPFDEPG
KPGTPEPVDW DKDRVDLVWR PPLNDGGSPI TGYVVEKREK GTDKWIKGAE INAPALGEEC
KASVPNLDEN CEYEFRVKAF NAAGSGEPSD ASKSVITRPR KLAPKIDRKN IRTYNIKAGE
PIFLDINVSG EPAPEISWTQ NGKIVYSTPA TKIENVPYNT KYINSNPERK DTGLYKIAAH
NLYGQDQVEF QINVITKPGK PEGPLEVSDV HKDGCKLKWK KPKDDGGEPI DSYLVEKFDP
DTGVWLPVGK SAVPEITVDG LIPGHEYKFR VKAVNKEGES EPLETLGSII AKDPFTAPSK
PGVPETTDWT ANKADLAWNE SASDGGSPIT GYIIEIKDKY SPLWEKALET DSPSPVATVN
GLIEGNEYQF RVIALNKGGQ SEPSEASKPF IAKPRYLAPK IDRRNLRDVT ISAGTALKLD
AVITGEPAPK VEWKFSNYPL QSGKNTTIET PDYYTKLVIR PTQRGDSGEY LVTATNSSGK
DSVLINVNIT DKPTPPNGPL QISDVHKEGC HLKWKRPNDD GGTPIEYFQI DKLDPETGYW
LPCGRSTEPQ ADITGLTPGN EYKFRVSAVN AEGESAPLVG EESIIAKNPF DEPGKPENLR
ATDWDKDHID LAWTPPLNDG GSPVTGYLVE KKDKYGQWEK ALEVPADQCK GTVPDLTEGE
AYEFRVSAIN AAGLGEPSDA TAPIVAKSRN KPPVIDRSNL IEVRIKAGQA FTFDCKISGE
PAPKTKWLLK KKEVFSKDNI KVTHIDYNTK LKVTNANRSD SGLYTVHAEN YNGEDSADVK
VTVIDKPSPP NGPLKVENVH AEGCTLNWNP PDDDGGQPIE NYAVEKMDEA TGRWVPAGES
HGPVTSLKLK GLTPGHKYKF RVRAKNRQGT SDPLTTHHAT EAKNPYDEPT KPGTPSIKDF
DKDFVDLEWA RPESDGGSPI SGYIIEKRDK YSPNWEPCAE IDGDVTSGHV SDLIEGVKYE
FRVRAVNKAG QGVPSDATEP HVARAKNVAP KIDRNFMLDI KIRAGNVFEF DVPVSGEPIP
SKEWTHEDNM VINTDRVKIS NYDDRTKLRI LDAKRADTGS YTLVARNING IDKHTVKVTV
LDVPTAPEGP LRGDEITKNS MTLRWRPPKD DGGSEITHYV VEKMDNEAMR WVPVGECAGT
EIRADNLIEN HDYNFRVRAV NKQGQSQPLT TSQAITAKDP YSHPDKPGQP QAVDWGKNFV
DLEWAAPKRD GGAPITSYIV EKRPKFGQWE RATVVPGDER KAHIPDLTDG GEYEFRVIAV
NRGGQSDPSD PSGTIVCKPR FLAPFFDKSL LDNITVHAGK RLGWTLPIEA SPRPTIKWLF
NGKEIEPSTR IESNLFQNEL TFEIPSALRA DEGRYTLILK NEHGSFDASA HATVLDRPSP
PKGPLDISKI TRDGCHLAWH VPDDDGGSPI LHYIIEKMDL SRGTWSDAGM STHPVHDVIR
LVHCKEYLFR VKAVNAIGES EPLEASKSII AKNEFDEPDS PSKPIVTDWD RDHVDLQWAA
PKSDGGAPLT EYIIQKKEKG SPYWVNVVHV PPNKTAATVP DLVEGQEYEF RVIAVNQAGQ
SEPSEPSDMI MAKPRFLAPK IITPLHEVRI KAGLIFHIDI DFIGEPAPEA IWTHNLNSLK
SNERSTITTI GHHTVVHTVN CQRSDSGIYH LLLRNDSGID EGSFELIVLD RPGPPDGPLE
YEEITANSVT ISWKPPKDNG GSEISAYVIE KRDLTHGGGW VPAVSFVNAK YNHAVVPRLL
EGTKYEFRVM AENLQGRSDP LTSEQPVIAK NQYTVPGAPG KPELSDSDKD HITIKWKQPI
SNGGSPILGY DIERRDVNTG RWIKINGEPV PTTEYRDDRV SPNHQYQYRV SAVNAAGNSK
PSEPSSTFNA RPMREKPRLY LDGLVGRRIK VRAGEPVNVN IPISGAPTPT IEWKRGDVKL
PESKNVSYDT NSERTIFRID DSTRQDSGVY KITATNEFGK DSADVKIIVV DKPTPPEGPL
TYTETAPDHI SLQWNPPKDD GGSEITGYII EFTEFSVDDW KPVPGYCPKT NYTVKGLTEG
KKYLFRVRAE NIYGVSDALE GKPVVAKSPF DPPGAPSQPQ VVAYTPSSAS LEWHPPDYCG
GKPISGYIVE RRERGGEWIK CNNYPTPNTS YTVPDLREGA RYEFRVIAVN EAGPGSPSKP
SEPMTAELQR YRPDPPEPPK PDRITKDSVT LSWRPPRNDG KSKIKGYYIE MRPKNSKDWK
PVNDIPIHST VFRVPDLKEG EEYWFRVIAE NDVGRSDPSK PSQPITIEEQ PNKPRMDLGG
VRDIICRAGD DFSIHVPYVG FPKPTASWYS NDTVLDDDQR VHQHLTDEAA SFVVKNSKRS
DSGQYRLQLK NPSGFDTATI NVKVLDRPGP PTNLRADEFA GDSLTLYWNP PKDDGGSPVQ
NYIIEKKEAR SSTWTKVSSY CTVPFVRIRN LTIGKEYDFR VIAENKYGQS DPANTSEPIR
ARHPFDVPNA PGIPRGIDST EDSITIAWSK PKHDGGSPIT GYVIEKRLLS EDKWTKAIHA
LCPDLTCKIP NLIENAEYEF RVAAVNAAGQ SLFSASSDLI YCRRPPHAPK ITSDLSIRDM
TVIAGEEFHI TVPYHANPRP VPSWNINGLE VSPDERIRFD TDDYSSVYHN KCAKRSETGS
YTITLVNSKG SDTASCHVTV VDRPGPPQGP LNAYDITPDT CTLAWKTPLD DGGSPITNYV
VEKLDTSGTW VKVSSFVRNT HYDVMGLEPN HKYHFRVRAE NQYGLSDPLE IPEPITAKHQ
FTVPDEPGQP KVIDWDSGNV TLIWTRPASD GGSRIQGYQI EYRDIVNDSS WNTYEYLIKD
TKYQLYNLTN GSEYEFRIKA KNAAGFSKPS PPSLRFKLKG KFNVPAPPGT PQVTKVGKNY
VDLKWEKPIS DGGSRITGYI IERRDIGGAV WVKCNDYNVL DTEFTVINLI EMGDYEFRIF
AINAAGRSEP SLCTMPIKVC EVLGGEKPDW ISRLQDRIAP SGKDFTLQCA ASGKPSPTAR
WLRNGKEIQM QPGGRFICDS KDGVFRLHIS NVQSGDDGDY TCEAINSLGF VHTSGYLKVG
SPPIINRCPS ELYLPESDNT KIKVYYSGDQ PLSVKITKNN ELISDGADES HFKYTIFDEY
IAIFIRDIIK SDAGNYQIEL SNDSGSATGH FDAYITGLPS APVGPMGISH INKHSCTLAW
RPPANVGGLR ITHYVVERKD ITSPHWITVS SSCKDTSFNV QGLLENQEYI FRVMAVNENG
IGAPLEGLNP IRAKAPIDPP SPPGIPEITE IGGDFVHLEW AKPESDGGAH IQGYWVDKRE
VGSDTWQRVN PIINAANQIN CHNLIEGRQY EFRIFAQNIA GLSKESTASQ VVKIVDPKAA
TAPIIVKSLR DANCIQNHNA QFTCTITGVP RPTITWYKGA REITSGARYY IYSEGDNHFL
NINDVFGEDA DEYVCRAVNK AGAKSTRAAL AIMTAPKLNV PPRFRDTAYF DKGENVVIKI
PFTGFPKPRI HWVREGENIE SGGHYNVEVK ERHAVLTIRD GSRLDSGPYR ITAENELGSD
TAIIQVQISD RPDPPRFPVV ESIGTDSLSL SWKAPIWDGG SDITNYYVER REHPLSSWIR
VGNTRFTSMA VTGLTPGKEY DFRVFADNVY GRSDASDIST LIKTKESIKK KPVERKWELD
ESGKRIRGKA DGPIKDYDSY VFDIFSKFVP QPVEISHESV YNRYDILEEI GNGAFGVVHR
CRERSTGNIF AAKFIPVSHA VEKDLIRREI DIMNQLHHQK LINLHDAFED DDEMVLILEF
LSGGELFERI TAEGYVMTEA EVINYMRQIC EGIRHMHEKN IIHLDIKPEN IMCQTRTSTN
VKLIDFGLAT RLDPNEVVKI TTGTAEFAAP EIVNREPVGF YTDMWATGVL AYVLLSGLSP
FAGDNDVQTL KNVKACDWDF DLEAFKHISD EGKDFIRKLL IASKEKRMTA HECLLHPWLT
GDHRELNQKI ARDRYLAYRE KLRKKYEDFG KYLLPIGRLA EYSSLRKLLM EKYKMHDAVF
DRRQAAPRFV IRPSSQFCYE GQSVKFYCRC IAIATPTLTW SHNNIELRQS VKFMKRYAGD
DYYFIINRVK LDDRGEYIIR AENHYGSREE VVFLNVHPLP KEQPKYRTES TPVRRREPLP
YTLWQEESES APSFTFLLRP RVMQARDTCK LLCCLSGKPV PTVKWYKDGR ELSKYEYAMT
HSDGVVTMEI IDCKPSDSGK YTCKATNCHG TDETSCVVIV EGEWVTPEQA ELAHNFLYSG
DRKYIEQHFK PTPPPIITTR QFTSSATSSN SQQTSSTRTT SDGKTVITNS SSSTQNSISS
KKKYAASSLQ APGSPSRSRS ATKELILPPD DSLMCKPEFT KPLHDLTISD GEQLLLTCHV
KGDPEPQITW SKNGKSISSS EIMDLKYKNG IATLTIHEVF PEDEGVFSCT ATNSISSVET
KCKLTIKPLD KQSSKRLPTG SDKPPKIVSH LESRFVKDGD AVTLACRIIG ADHFDVVWLH
NNKEIKPSKD FQYSNEANIY RLQIAEIFPE DGGTYTCEAF NDAGESFSTC TINVNVPGDE
PKVPTFVKFP VSVSVTEGEN ATFECESDGE LINLAWLKDG KPIDEARARY SFTKDSNRYK
FSVNKCTLDD VGQYQARAVS KKGESLCAFS VNVLSSEA
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