ID A0A0Q9WVZ8_DROVI Unreviewed; 8966 AA.
AC A0A0Q9WVZ8;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Uncharacterized protein, isoform T {ECO:0000313|EMBL:KRF85423.1};
GN Name=Dvir\GJ15760 {ECO:0000313|EMBL:KRF85423.1};
GN ORFNames=Dvir_GJ15760 {ECO:0000313|EMBL:KRF85423.1};
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244 {ECO:0000313|EMBL:KRF85423.1, ECO:0000313|Proteomes:UP000008792};
RN [1] {ECO:0000313|EMBL:KRF85423.1, ECO:0000313|Proteomes:UP000008792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00006692}.
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DR EMBL; CH940665; KRF85423.1; -; Genomic_DNA.
DR RefSeq; XP_015024043.1; XM_015168557.1.
DR EnsemblMetazoa; FBtr0441377; FBpp0397910; FBgn0202948.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR CDD; cd00063; FN3; 39.
DR CDD; cd00096; Ig; 3.
DR CDD; cd05748; Ig_Titin_like; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 78.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR14340:SF24; -; 1.
DR PANTHER; PTHR14340; MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3; 1.
DR Pfam; PF00041; fn3; 38.
DR Pfam; PF07679; I-set; 35.
DR Pfam; PF00069; Pkinase; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 39.
DR SMART; SM00409; IG; 38.
DR SMART; SM00408; IGc2; 31.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 21.
DR SUPFAM; SSF48726; Immunoglobulin; 39.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50853; FN3; 39.
DR PROSITE; PS50835; IG_LIKE; 31.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 9..102
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 122..212
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 231..324
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 338..429
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 441..534
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 546..638
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 643..731
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 749..838
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1753..1831
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1848..1932
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2126..2223
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2226..2324
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2328..2418
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2425..2521
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2527..2622
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2724..2821
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2827..2921
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2926..3018
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3022..3121
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3127..3222
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3226..3315
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3323..3417
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3424..3519
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3523..3613
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3621..3714
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3720..3815
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3819..3908
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3916..4009
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4015..4110
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4114..4202
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4209..4303
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4309..4408
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4412..4501
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4509..4602
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4605..4703
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4707..4798
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4804..4897
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4903..4997
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5000..5090
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5098..5193
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5199..5293
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5298..5387
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5395..5488
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5494..5588
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5553..5681
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5688..5782
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5788..5883
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5983..6080
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6086..6181
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6185..6274
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 6283..6377
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6383..6476
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6483..6578
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6572..6669
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 6678..6772
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6778..6873
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6974..7068
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7074..7169
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7175..7270
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7276..7366
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 7469..7564
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7570..7665
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7665..7759
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 7764..7857
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 7862..7955
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 8012..8267
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 8335..8423
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 8460..8547
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 8665..8753
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 8773..8861
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 8872..8960
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 839..863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1047..1202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1218..1307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1339..1497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3205..3226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3698..3728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3994..4020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5174..5204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5470..5499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6459..6506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6561..6586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6758..6782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8576..8650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1047..1078
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1090..1106
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1122..1202
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1244..1307
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1346..1367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1376..1406
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1420..1434
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1479..1497
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5470..5486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8582..8649
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 8041
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 8966 AA; 1003157 MW; 49F33549887310A3 CRC64;
MGVAEDFAPS FVKKPQLHQE DDGNRLIFEC QLVSSPKPDI EWFRSDNKLT EDARTKFKIQ
PIGDNKFTVV LELDDVVETD AGLYKVKAKN KSGEVSASIN LNFTLGKFSL LEDLRQIDGF
APTFAKKPAI RQEEDGKRLL FECRVNADPL PNITWFHNGT TVQESPRHRL TIDKDVHSYF
ATLEIQNVTV EDAGKYKVNA KNELGESNAT ISLNFDSDEA PVPESTDGIK PTFTERPVIR
QSEDGGNVTF ECRCVGDPTP TVTWSHGETV LSEGKRYKMS LTLDQKLYHM ARLEISSVVS
SDQGEYRAQA KNKHGSGVAT INLNFESGSK KIPDGKSPRF PKKPTIRQEE DILIMECILE
AHPVPDITWY CSDKQILDNQ RTKMTRKAIT KDSYVLTLEI QYPTKDDGGN YRCNAINMFG
ESNANIALNF QGANDANGFA PSFIEKPRII PNETGTLITM KCKCKAKPEP TVKWYRGQDL
VEKSKKIKIN STVIAEDTYE LTLEIKDPGA TDGGTYRCNV KNEYGESNAN LNLNIEAEPE
PEGEGPTFIE KPRIISENNG KLVIMECKVK ADPKPDIVWF RNGEVIKESN KLKIFMEQRG
DQYYIKLELI DPQLEDSGLY KCNIKNSLGE LNANLTLNIE IVPVIKDKPK IIKIIKKRTV
VIECVVVSKF EPKCTWYKET NTVAESKRHV YLVEKTKEGE FAVKLEINEV EDSDKGAYKL
VASNEKGEAV SQVVNLVDIP EEERKPSKPD IARKLVDQKV TESKTFELII SLKNSDRKCK
VEWYKGSTLI RETKDITTTF DGTTARLTFS SAKSEHTSNY KVVVSNELGK DESTCKVTVE
KKDKKKDEKS EQDKEKEEAE KKRKVIETKT KTKTKEISQQ EDLAEREQQT NQISLKVQNN
QIVNQQISVT SYEQAYIQEQ QSTLIVQQTK QTEQQQVSET HVSYSSEVQK AHHQELLVQE
HSSPKVQAKV SSTCTIETQP TSGLTIYQIP KLKSRKTSEP PVNASESKEK NIFGVKLTPV
RHVLNDEEPA EQIGLKKVER RASIVSVKEE SKSETRRKSI IKSHEQTSEE DTKTVSRRSS
FAVEENVSES RRSSVVDKKA LEQVESKKIE ANNNPQAIKE EIPKLKPADK RRIPKAVEEQ
KPAEELPKLR KTSIAKPKEE PIPEAAKPKA KGKLKAKPKY EELPEIPDYE RPALEKYEKS
DFTPSDFARE LEIPNKMEKP ALETAKKPAE IVPQKNGLPK KTEVVEQPAE EPKTIKLGKG
KLPDDEDTRD GATLKPVIVE PEKDKQNTDK SEEAEKPSLM DIIKQRRRSS VRNLMTKEPI
QNESFLGVVL KPVVKDAKEQ VAPQQAKQLH KANITENFNP TKSSKAQISD MKKPEALATI
VDDYERPKLE KYEPIEFEKT KSEKPTPVVK SPDQNTPEVK LPVEDSKEEK PKVPKMQPPA
PGDPPKIEVI REKRPSLAPE PPSRRGSLVP PADTGRRPSL IINDERRRPS IDVRRPSVQD
LEDLINKPST PLRDIGDGGP PTIIDVQESY SAVEDSTAYL TVGVEGNPAP TFKFYKGVTE
IIEGGRYKFL TDGQTNTITL CMRKCKPNDE GKYKVVVSNI HGEDSAEMQL YVSDSSGMDF
RAMLKKRRYQ KWDKEEQDPN WGDLKETEKP LPALKKVERK VESFLSPLID QFAKEGKDKK
VVFEARFSKP NCKPKWLFRK DEVFTGSKFK FKQENDTYQL IISTPKVEDS GKYTIEIGGV
SSTAFLNVEE ADPTYTFTKP LKKKLEGFTR HETTLECSVS SSMANVSWFK DNQKLESDDP
RYLISKDING NLKLIIKESV LEDAGQYRCQ LDKQPDKTEC ALKIVEYPYK FVKVLKSQQC
VEKDTVTLAC EIDDAQGDVQ WFRNGEEIKP DKRMQVVKDG RKRKLIIKDC KVTDAGQFKC
TTNADQTDAE IIINYQNRFN KKLKDTDAVE REKLVLDVEL QDQTAPCDWK FNGEPIVPNE
RIEIKNLGGG KHQLVFNGLD LSDAGEITCE SGQLTSTCKL SVRKGESRPN IDCPDEFAEP
ISAPVVIEVP YKVSGTKQTP VEGKLIKDGK PLPLKDVEVA ITDDKITFKI KKPSRDLSGP
YQIKISNAQG EDTKDVNIIC QDVPQPPQDV DVTDVYQTSC VVNFKPPTDD GGSPITKYVI
ERQDLSKKQG WEPVAEVLPN EPRLKKIDDL VPKKQYRFRI RAVNKLGPSD PATFKNSILA
KDPWDEPGKP KAVDLTDWDK DHADLKWEAP DSDGGDPITS YVIEYKEKFS NDWVPGREVP
GDARTGTVEN LKEGQQYEFR VRAVNRAGPG EPSDKTKPII AKCRFVKPFL VGDGLKNITV
KKGQTIRYDI KYDGEPEPVA SWIKSNEPLK FDNQRICLEQ LERNSSITIK KSVRNDTGKY
KLVLTNSSGT IESEAQVVVL DRPLAPGGPF EPEEVRAHRI KMKWKRPPDD GGCEITGYAL
ERMDEETGRW IPSGEVGPDE TSFDFKGLTP NKKYKFRVKA INKEGESEPL ETTDAILAKN
PYDPPSPPSQ PVIDDYDNKS VSLKWKRPPS DGGRPVTHYV VEFKDKFSPT WSEVAKTEDP
TPECKVEGLK EKMVYQFRVR AVNKAGPSEP SQPTDNHLCK HKNLKPQIDR STFKRVTIKS
GRTHKWSVDI TGEPVPELHW SWRDDIALTT GDRISIENVD YHTDFVIMNA KRQDSGFYSL
KAENRNGVDR ETVELVVLGK PSSPKGPLAV SDVTATGCKL QWKKPEDDGG IPIKEYVVEK
MDTATGKWVR VGRSPGEKEP PSFDVTGLNP GSEYMFRVSA VNEEGESEPL TTLVGVVAKD
PFDEPNKPGT PEVIDYDNQS ISLKWTPPKN DGGAPIQKYI IEKKDKNKPD WEKALEIPGD
QLEAAVAGLQ EYGEYQFRVI AVNKAGPSPP SDASVPQVAK YKKLKPRIDR SNLKPLLIRA
GKPIKYDVNV RGEPVPTITW YQNDKELKPE DLPTNCEIQN IPHNTKISII DTVRKHTGTY
KIRAVNEHGE DEADVEVNVL APPGKPKGPL AVKDITKDSC KLKWQKPDDD GGKPITAYQV
EKFDKKQGRW VPVGRASGND TEFDVKGLQE GHEYQFRVKA INEEGESEPL ETDGSILAKN
PYDAASKPGT PKIDDYNEHM VKLKWDAPKH DGGAPITGYI IEKKDKFSPI WDEVFTTNTP
APEAIVDGLT EGNVYQFRVR AINKAGTSEP SDPTEPHLAK PRNLKPSINR EKMKPVKVRA
GQTVKFDVDV KGEPAPTLTW SFKEKEVTPS GQLRLDNDDY NTKLVLLDTT RKDTGVYKLK
AENINGVDEA EVEVIILDKP AKPEGPLEVS DIHKEGCKLK WKKPKDDGGV PLSGYAIEKM
DTATGKWVPC GTVDPEKTEF DVKGLDPNHR YQFRVRALNE EGESEPLETE SAITAKNPFD
ISAPPGLPEL EDWDEHHVKL KWEPPIRDGG TPITNYIIEV MDKDSGEFVK ASETEGPICK
GVVKKLEEGQ QYKFRVRAVN KAGPSEPSEQ TNWHTAKPRF LKPHIDRTNL KPVIVKAGLS
ISLDINVKGE PAPKVEWLFN GLPVISDEEG IKIDNVDYNT KFFVMRAKRP QSGKYTIKAT
NEVGEDVADL DVTVLGKPGK PKGPLEVNDM TKHSCKLKWE KPEDDGGAPI DYYEIEKLDP
HTGQWLPCGK SAEPEAKVIG LHEGKPYKFR VRAVNKEGES EDLETDKPVI AKNPFDEPDK
PGRPEPTNWD KDFVDLAWDP PKNDGGAPIQ KYIIQMRDKS GRAWVDAATV PSDKTKGTVT
AVEEGHEYEF RVVAINKAGP SEPSDVSKSV VAKPRFLKPH IDRKNLQKKI MRSGQMLHMD
AAVKAEPPAK ITWTYNGAEI KTSDKIKIEN EEYKTTFIMP KVRRADKGTY IVTAKNDSGV
DTVDVELEVL CKPSKPKGPL AVSDVTAESV HLKWHKPDDD GGEPIEHYVV ERMDTETGRW
VPVLTTKTPE ADVTGLTEGK EYLFRVKAVN AEGESEPLVT DTPVTAKNPY DAADTPGKPQ
ITDWSANHAD LKWRAPDDDG GAPITGYIIE KKDNNTGKWQ KVLETNTPDC KTRVNDLIEG
TKYQFRVKAV NKAGQSKPSE ASDQMSAKDR FAAPKIDRTN IKDITVKAGQ HIRFDIKVSG
EPPPSKTWFH NKARIDDDDY NIDIESYRTK LAVPFAKRLH SGKYTIKAEN ESGHDEASFE
VTVLDKPAPP EGPLRVTDVH KEGCKLKWNP PMDDGGLPIE HYVVEKMDVE TGRWLPSGRF
KEPFAELNNL EPGHEYKFRV LAVNTEGESE PLVGEHSIVA KNPFDEPGKP GTPEPVDWDK
DRVDLVWRPP LNDGGSPITG YVVEKREKGT DKWIKGAEIN APALGEECKA SVPNLDENCE
YEFRVKAFNA AGSGEPSDAS KSVITRPRKL APKIDRKNIR TYNIKAGEPI FLDINVSGEP
APEISWTQNG KIVYSTPATK IENVPYNTKY INSNPERKDT GLYKIAAHNL YGQDQVEFQI
NVITKPGKPE GPLEVSDVHK DGCKLKWKKP KDDGGEPIDS YLVEKFDPDT GVWLPVGKSA
VPEITVDGLI PGHEYKFRVK AVNKEGESEP LETLGSIIAK DPFTAPSKPG VPETTDWTAN
KADLAWNESA SDGGSPITGY IIEIKDKYSP LWEKALETDS PSPVATVNGL IEGNEYQFRV
IALNKGGQSE PSEASKPFIA KPRYLAPKID RRNLRDVTIS AGTALKLDAV ITGEPAPKVE
WKFSNYPLQS GKNTTIETPD YYTKLVIRPT QRGDSGEYLV TATNSSGKDS VLINVNITDK
PTPPNGPLQI SDVHKEGCHL KWKRPNDDGG TPIEYFQIDK LDPETGYWLP CGRSTEPQAD
ITGLTPGNEY KFRVSAVNAE GESAPLVGEE SIIAKNPFDE PGKPENLRAT DWDKDHIDLA
WTPPLNDGGS PVTGYLVEKK DKYGQWEKAL EVPADQCKGT VPDLTEGEAY EFRVSAINAA
GLGEPSDATA PIVAKSRNKP PVIDRSNLIE VRIKAGQAFT FDCKISGEPA PKTKWLLKKK
EVFSKDNIKV THIDYNTKLK VTNANRSDSG LYTVHAENYN GEDSADVKVT VIDKPSPPNG
PLKVENVHAE GCTLNWNPPD DDGGQPIENY AVEKMDEATG RWVPAGESHG PVTSLKLKGL
TPGHKYKFRV RAKNRQGTSD PLTTHHATEA KNPYDEPTKP GTPSIKDFDK DFVDLEWARP
ESDGGSPISG YIIEKRDKYS PNWEPCAEID GDVTSGHVSD LIEGVKYEFR VRAVNKAGQG
VPSDATEPHV ARAKNVAPKI DRNFMLDIKI RAGNVFEFDV PVSGEPIPSK EWTHEDNMVI
NTDRVKISNY DDRTKLRILD AKRADTGSYT LVARNINGID KHTVKVTVLD VPTAPEGPLR
GDEITKNSMT LRWRPPKDDG GSEITHYVVE KMDNEAMRWV PVGECAGTEI RADNLIENHD
YNFRVRAVNK QGQSQPLTTS QAITAKDPYS HPDKPGQPQA VDWGKNFVDL EWAAPKRDGG
APITSYIVEK RPKFGQWERA TVVPGDERKA HIPDLTDGGE YEFRVIAVNR GGQSDPSDPS
GTIVCKPRFL APFFDKSLLD NITVHAGKRL GWTLPIEASP RPTIKWLFNG KEIEPSTRIE
SNLFQNELTF EIPSALRADE GRYTLILKNE HGSFDASAHA TVLDRPSPPK GPLDISKITR
DGCHLAWHVP DDDGGSPILH YIIEKMDLSR GTWSDAGMST HPVHDVIRLV HCKEYLFRVK
AVNAIGESEP LEASKSIIAK NEFDEPDSPS KPIVTDWDRD HVDLQWAAPK SDGGAPLTEY
IIQKKEKGSP YWVNVVHVPP NKTAATVPDL VEGQEYEFRV IAVNQAGQSE PSEPSDMIMA
KPRFLAPKII TPLHEVRIKA GLIFHIDIDF IGEPAPEAIW THNLNSLKSN ERSTITTIGH
HTVVHTVNCQ RSDSGIYHLL LRNDSGIDEG SFELIVLDRP GPPDGPLEYE EITANSVTIS
WKPPKDNGGS EISAYVIEKR DLTHGGGWVP AVSFVNAKYN HAVVPRLLEG TKYEFRVMAE
NLQGRSDPLT SEQPVIAKNQ YTVPGAPGKP ELSDSDKDHI TIKWKQPISN GGSPILGYDI
ERRDVNTGRW IKINGEPVPT TEYRDDRVSP NHQYQYRVSA VNAAGNSKPS EPSSTFNARP
MREKPRLYLD GLVGRRIKVR AGEPVNVNIP ISGAPTPTIE WKRGDVKLPE SKNVSYDTNS
ERTIFRIDDS TRQDSGVYKI TATNEFGKDS ADVKIIVVDK PTPPEGPLTY TETAPDHISL
QWNPPKDDGG SEITGYIIEF TEFSVDDWKP VPGYCPKTNY TVKGLTEGKK YLFRVRAENI
YGVSDALEGK PVVAKSPFDP PGAPSQPQVV AYTPSSASLE WHPPDYCGGK PISGYIVERR
ERGGEWIKCN NYPTPNTSYT VPDLREGARY EFRVIAVNEA GPGSPSKPSE PMTAELQRYR
PDPPEPPKPD RITKDSVTLS WRPPRNDGKS KIKGYYIEMR PKNSKDWKPV NDIPIHSTVF
RVPDLKEGEE YWFRVIAEND VGRSDPSKPS QPITIEEQPN KPRMDLGGVR DIICRAGDDF
SIHVPYVGFP KPTASWYSND TVLDDDQRVH QHLTDEAASF VVKNSKRSDS GQYRLQLKNP
SGFDTATINV KVLDRPGPPT NLRADEFAGD SLTLYWNPPK DDGGSPVQNY IIEKKEARSS
TWTKVSSYCT VPFVRIRNLT IGKEYDFRVI AENKYGQSDP ANTSEPIRAR HPFDVPNAPG
IPRGIDSTED SITIAWSKPK HDGGSPITGY VIEKRLLSED KWTKAIHALC PDLTCKIPNL
IENAEYEFRV AAVNAAGQSL FSASSDLIYC RRPPHAPKIT SDLSIRDMTV IAGEEFHITV
PYHANPRPVP SWNINGLEVS PDERIRFDTD DYSSVYHNKC AKRSETGSYT ITLVNSKGSD
TASCHVTVVD RPGPPQGPLN AYDITPDTCT LAWKTPLDDG GSPITNYVVE KLDTSGTWVK
VSSFVRNTHY DVMGLEPNHK YHFRVRAENQ YGLSDPLEIP EPITAKHQFT VPDEPGQPKV
IDWDSGNVTL IWTRPASDGG SRIQGYQIEY RDIVNDSSWN TYEYLIKDTK YQLYNLTNGS
EYEFRIKAKN AAGFSKPSPP SLRFKLKGKF NVPAPPGTPQ VTKVGKNYVD LKWEKPISDG
GSRITGYIIE RRDIGGAVWV KCNDYNVLDT EFTVINLIEM GDYEFRIFAI NAAGRSEPSL
CTMPIKVCEV LGGEKPDWIS RLQDRIAPSG KDFTLQCAAS GKPSPTARWL RNGKEIQMQP
GGRFICDSKD GVFRLHISNV QSGDDGDYTC EAINSLGFVH TSGYLKVGSP PIINRCPSEL
YLPESDNTKI KVYYSGDQPL SVKITKNNEL ISDGADESHF KYTIFDEYIA IFIRDIIKSD
AGNYQIELSN DSGSATGHFD AYITGLPSAP VGPMGISHIN KHSCTLAWRP PANVGGLRIT
HYVVERKDIT SPHWITVSSS CKDTSFNVQG LLENQEYIFR VMAVNENGIG APLEGLNPIR
AKAPIDPPSP PGIPEITEIG GDFVHLEWAK PESDGGAHIQ GYWVDKREVG SDTWQRVNPI
INAANQINCH NLIEGRQYEF RIFAQNIAGL SKESTASQVV KIVDPKAATA PIIVKSLRDA
NCIQNHNAQF TCTITGVPRP TITWYKGARE ITSGARYYIY SEGDNHFLNI NDVFGEDADE
YVCRAVNKAG AKSTRAALAI MTAPKLNVPP RFRDTAYFDK GENVVIKIPF TGFPKPRIHW
VREGENIESG GHYNVEVKER HAVLTIRDGS RLDSGPYRIT AENELGSDTA IIQVQISDRP
DPPRFPVVES IGTDSLSLSW KAPIWDGGSD ITNYYVERRE HPLSSWIRVG NTRFTSMAVT
GLTPGKEYDF RVFADNVYGR SDASDISTLI KTKESIKKKP VERKWELDES GKRIRGKADG
PIKDYDSYVF DIFSKFVPQP VEISHESVYN RYDILEEIGN GAFGVVHRCR ERSTGNIFAA
KFIPVSHAVE KDLIRREIDI MNQLHHQKLI NLHDAFEDDD EMVLILEFLS GGELFERITA
EGYVMTEAEV INYMRQICEG IRHMHEKNII HLDIKPENIM CQTRTSTNVK LIDFGLATRL
DPNEVVKITT GTAEFAAPEI VNREPVGFYT DMWATGVLAY VLLSGLSPFA GDNDVQTLKN
VKACDWDFDL EAFKHISDEG KDFIRKLLIA SKEKRMTAHE CLLHPWLTGD HRELNQKIAR
DRYLAYREKL RKKYEDFGKY LLPIGRLAEY SSLRKLLMEK YKMHDAVFDR RQAAPRFVIR
PSSQFCYEGQ SVKFYCRCIA IATPTLTWSH NNIELRQSVK FMKRYAGDDY YFIINRVKLD
DRGEYIIRAE NHYGSREEVV FLNVHPLPKE QPKYRTESTP VRRREPLPYT LWQEESESAP
SFTFLLRPRV MQARDTCKLL CCLSGKPVPT VKWYKDGREL SKYEYAMTHS DGVVTMEIID
CKPSDSGKYT CKATNCHGTD ETSCVVIVEG EWVTPEQAEL AHNFLYSGDR KYIEQHFKPT
PPPIITTRQF TSSATSSNSQ QTSSTRTTSD GKTVITNSSS STQNSISSKK KYAASSLQAP
GSPSRSRSAT KELILPPDDS LMCKPEFTKP LHDLTISDGE QLLLTCHVKG DPEPQITWSK
NGKSISSSEI MDLKYKNGIA TLTIHEVFPE DEGVFSCTAT NSISSVETKC KLTIKPLDKQ
SSKRLPTGSD KPPKIVSHLE SRFVKDGDAV TLACRIIGAD HFDVVWLHNN KEIKPSKDFQ
YSNEANIYRL QIAEIFPEDG GTYTCEAFND AGESFSTCTI NVNVPGDEPK VPTFVKFPVS
VSVTEGENAT FECESDGELI NLAWLKDGKP IDEARARYSF TKDSNRYKFS VNKCTLDDVG
QYQARAVSKK GESLCAFSVN VLSSEA
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