ID A0A0Q9X0W9_DROWI Unreviewed; 2049 AA.
AC A0A0Q9X0W9;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Uncharacterized protein, isoform C {ECO:0000313|EMBL:KRF97549.1};
GN Name=Dwil\GK20754 {ECO:0000313|EMBL:KRF97549.1};
GN ORFNames=Dwil_GK20754 {ECO:0000313|EMBL:KRF97549.1};
OS Drosophila willistoni (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7260 {ECO:0000313|EMBL:KRF97549.1, ECO:0000313|Proteomes:UP000007798};
RN [1] {ECO:0000313|EMBL:KRF97549.1, ECO:0000313|Proteomes:UP000007798}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14030-0811.24 {ECO:0000313|Proteomes:UP000007798};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CH963846; KRF97549.1; -; Genomic_DNA.
DR RefSeq; XP_015034720.1; XM_015179234.1.
DR STRING; 7260.A0A0Q9X0W9; -.
DR EnsemblMetazoa; FBtr0420946; FBpp0379056; FBgn0222750.
DR eggNOG; KOG3614; Eukaryota.
DR InParanoid; A0A0Q9X0W9; -.
DR Proteomes; UP000007798; Unassembled WGS sequence.
DR GO; GO:0034703; C:cation channel complex; IEA:EnsemblMetazoa.
DR GO; GO:0097682; F:intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity; IEA:EnsemblMetazoa.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:EnsemblMetazoa.
DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR Gene3D; 1.20.5.1010; TRPM, tetramerisation domain; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR InterPro; IPR032415; TRPM_tetra.
DR InterPro; IPR037162; TRPM_tetra_sf.
DR PANTHER; PTHR13800:SF1; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR Pfam; PF16519; TRPM_tetra; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007798};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 940..960
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1007..1025
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1074..1095
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1154..1174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 204..471
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 948..1179
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1270..1325
FT /note="TRPM tetramerisation"
FT /evidence="ECO:0000259|Pfam:PF16519"
FT REGION 77..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1482..1520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1718..1749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1803..1822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1831..1863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1882..1906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1926..1959
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1980..2009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2029..2049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1482..1503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1831..1858
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1929..1943
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2049 AA; 227780 MW; C6C68498BED52F39 CRC64;
MVVIDSPLAP HKYLRRISKD FSTVRRYSNT PLPTPIHTVA TTANASASYA STSAAFIAAE
AKASAASVAS AAAAVSGNSP HGIRKRRQRR KRSSVSSTLS KVLILNVRDL LKAQANNPNP
EDEHQPRSWI ETNFQKRECI KFIPCPKDDT KCCCGQAQIT HQTIAGIESG SPGDLWLPTK
HTRPQPTDAY GTIEFQGGAH PTKAQYVRLS FDTRPELLVQ LFTKEWNLEL PKLLITVQGG
KANFDLQAKL KKEIRKGLLK AAKTTGAWIF TGGTNTGVTK QVGDALLLEG QQRTGRVVSI
GIAPWGIVER NHELLGHNRE VPCHSISSPR SKLAVLNNRH AYFLLVDNGT QAKYGAELIL
RRKLEKFISN LKLHPFTHSS TPVVCLVIEG GTNTIRAVLE YVTDSPPVPV VVCDGSGRAA
DLLAFVHKYA SDGEEQPVLE SMRDYLIGTI QKTFEVGLDQ SEKLYQELLQ CTRNKNLITV
FRIQEKPEGE AQELDQTILT ALFKSQHLSP PEQLSLALTW NRVDIARSEI FVYGQEWPNG
ALDEAMMQAL EHDRIDFVKL LLENGVSMKK FLTIPRLEEL YNTKHGPANT LGYILRDVRP
HIPKGYIYTL HDIGLVINKL MGGAYRSYYT RRKFRPIYAK VMNSYANACR KSSTYQYQRY
AGANSLSLVT GLLPFTSEMA LFEFPFNELL IWAVLTKRQQ MALLMWTHGE EALAKSLVSC
KLYKAMAHEA AEDDLDTEIY EELRSYAKEF ESKGNKLLDF SYRQDAEKAQ RLLTCELHSW
SNQSCLSLAV AANHRALLAH PCSQVILADL WMGGLRTRKN TNFKVILGLI MPFYIRQLDF
KSKEELQQMP QTEEEHLENQ NLDNDDSDRS QPDAEALLAD TYSVRDTKVH ENGKVSLTDS
DPSQFRDIFH MAEYSEIKQH QPLRLKKKFH EFYTAPITKF WADSIAYMFF LIMFSFTVLV
KMGPAPRWQE WYSIAYITTL GFEKVREIIS SEPVAITHKF SVWAWNMWNP CDGAAIILFL
IGLAFRFRPS TMDIGRVIYC VDSIYWYLRI LNILGVNKYL GPLVTMMGKM VKNMIYFVVL
LAVVLMSFGV SRQAILYPNN EPTWRLIREV TYQPYFMLYG EVFADDIDPP CGEDPKQGAC
VTGRWVTPIT MSMYLLIANI LLINLLIAVF NNIFNEVNSV SHQVWMFQRF TVVMEYQQKP
VLPPPFIAFC HFYSLLKYCV RKAKGLEVQR DNGLKLFLEK DDLERLYDFE EECVEGFFHE
QEIILNQSTD ERVKNTTERV ETMSQKIEDI NQKENIQTAT VQNIEFRLRK MEESSEQILS
HLAVIHRFMS THIAGTDDLR GSVMNIPVEM HRVRTISIGG GGGGSGGAGG GGGGNGGGGN
LALGLSAALN LNSLQVNNRR RFNRSLTEVR PDAYILDEGT HFEVVPLPEE PDEVVKSREA
LNEQVVRKAS MISEADSDIY LPLSQRPSTC ETVKRTPYVT VRQDTEASTE SKDTLTPLGN
NDDDQTLVGG GGDNSDDAAP DINFEAARHR ALRQRTVSLC RRNSETYSLT GADINRSHIS
LNQLTSLSRR QLSLTQSEPD SDKDIPVVVA AAAAAAAAAA HQGKSVLHAK PSRNILLKLH
SEYTSITDEL ESVCHMIASP TVSLQSNKAS LDRPKTEMSR AEAAALQEKK HLKECEENDY
RILEGLFEAR GSIDASAQPF EIGVSVDYSH RYPLRRETAI ELSPSKPTAE GGPLGGAGDS
SDTSGAGSSS AMVVVASGFQ LKNERPWQRN SSMEQQSYQS PLVPTRATSD FLNPPYESTG
RLFKKSSESL QKNSSTDTDY SAHPYRFIKQ SSNETNTSLT GSYNVDTPSL TAEPSLDAGD
THSATGIGIG VGAATARYQP KRTASVGAAD GKRLRDESSS SLDLSAAPVA MQAAPALPIR
PMQLKKQFSM DQGKPQPTGS GGSALSAAAA VDVNPPDSRE AAAQVGAKLI SMQLKPQLGM
NVLKESSSST EESRDGDPHS LTLSAASSSN LTIPQISTHL VQDEIAKLSS NIKSSTESEK
DPPYNETMC
//
