ID A0A0Q9X728_DROMO Unreviewed; 2019 AA.
AC A0A0Q9X728;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Uncharacterized protein, isoform L {ECO:0000313|EMBL:KRG04096.1};
GN Name=Dmoj\GI19939 {ECO:0000313|EMBL:KRG04096.1};
GN ORFNames=Dmoj_GI19939 {ECO:0000313|EMBL:KRG04096.1};
OS Drosophila mojavensis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7230 {ECO:0000313|EMBL:KRG04096.1, ECO:0000313|Proteomes:UP000009192};
RN [1] {ECO:0000313|EMBL:KRG04096.1, ECO:0000313|Proteomes:UP000009192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15081-1352.22 {ECO:0000313|Proteomes:UP000009192};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CH933808; KRG04096.1; -; Genomic_DNA.
DR RefSeq; XP_015018700.1; XM_015163214.1.
DR EnsemblMetazoa; FBtr0430852; FBpp0388185; FBgn0142676.
DR Proteomes; UP000009192; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:UniProt.
DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR Gene3D; 1.20.5.1010; TRPM, tetramerisation domain; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR InterPro; IPR032415; TRPM_tetra.
DR InterPro; IPR037162; TRPM_tetra_sf.
DR PANTHER; PTHR13800:SF1; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR Pfam; PF16519; TRPM_tetra; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009192};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 913..931
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 975..993
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1042..1063
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1122..1142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 176..457
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 915..1147
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1238..1293
FT /note="TRPM tetramerisation"
FT /evidence="ECO:0000259|Pfam:PF16519"
FT REGION 24..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 833..867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1465..1488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1714..1826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1839..1882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1948..1981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1999..2019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 833..861
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2019 AA; 224731 MW; C73FA0369DE59C30 CRC64;
MVIDSPHAAH KYLRRISRDF STVRRFSNTP PVGPATPPPT TAPSVDGADA LPSTPRGIRK
RQRLRKRSSV SSTLSKVLIL NVRDLLRAQP EPTPEHQPRS WIETNFQKRE CIKFIPCPKD
DTKCCCGQAQ ITHQTIAGIE SGSPGDTWLP TKHTRPQPTD AYGTIEFQGG AHPTKAQYVR
LSFDTRPELL VQLFTKEWNL ELPKLLITVQ GGKANFDLQA KLKKEIRKGL LKAAKTTGAW
IFTGGTNTGV TKQVGDALLL EGQQRTGRVV SIGIAPWGIV ERNHELLGHN REVPCHSISS
PRSKLAVLNN RHAYFLLVDN GTMAKYGAEL ILRRKLEKFI SNLKLHPSRG TVVRSSKLCT
KLTHSSTPVV CLVIEGGTNT IRAVLEYVTD SPPVPVVVCD GSGRAADLLA FVHKYASDGE
EQPVLESMRD YLIGTIQKTF EVGLDQAEKL YQELLQCTRN KNLITVFRIQ EKPEGEAQEL
DQTILTALFK SQHLSPPEQL SLALTWNRVD IARSEIFVYG QEWPNGALDE AMMQALEHDR
IDFVKLLLEN GVSMKKFLTI PRLEELYNTK HGPANTLGYI LRDVRPHIPK GYIYTLHDIG
LVINKLMGGA YRSYYTRRKF RPIYAKVMNS YANACRKSST YQYQRYAGAN SLSLVTGLLP
FTTEMALFEF PFNELLIWAV LTKRQQMALL MWTHGEEALA KSLVACKLYK AMAHEAAEDD
LDTEIYEELR SYAKEFESKG NKLLDFSYRQ DAEKAQRLLT CELHSWSNQS CLSLAVAANH
RALLAHPCSQ VILADLWMGG LRTRKNTNFK VILGLIMPFY IRQLDFKSKE ELQQMPQTEE
EHLENQNLDN DDSDRSQPDA EVSLTDSDPS QFREFFHLSE FTNEIKQHQP LRLKKKFYEF
YTAPITKFWA DSIAYMFFLI MFSFTVLVKM GPIPRWQEWY SIAYITTLGF EKVREIVSSE
PVAITHKFSV WAWNMWNPCD GAAIILFLIG LAFRFRPNTM DIGRVIYCVD SIYWYLRILN
ILGVNKYLGP LVTMMGKMVK NMIYFVVLLA VVLMSFGVSR QAILYPNNEP TWRLIREVTY
QPYFMLYGEV FADDIDPPCG EDPRQPACVT GHWVTPITMS MYLLIANILL INLLIAVFNN
IFNEVNSVSH QVWMFQRFTV VMEYQQKPVL PPPFIAFCHF YSLLKYCVRK AKGLEVQRDN
GLKLFLEKDD LERLYDFEEE CVEGFFHEQE IILNQSTDER VKNTTERVET MAQKIEDINQ
KENIQTATVQ NIEFRLRKME ESSEQILSHL GVIHRFMSAH TTGNEELLRG SVMNIPGEMH
RMRTISMSDN EGSGGAGGGG GGSGGGGGGG GGIGVGGSAG IAASLGLGAA LTLNSLQVNN
RRRFNRSLTE VRPDAYILDE GTHFEVVPLP EEPDEVVKSR EALNEQMVRK ASMQSEADSD
IYLPLSQRPS TCDTVKRTPY VTVRQDTGAS TESKDTLTPM GNNDDDQTLV GGDNSDDAAP
DMTFEAARHR ALRQRTVSLC RRNSETYSLA GADINRSHIS LNQLTTLSRR QMSLTHSEPD
SDKDMPPVPQ TGKSVLHAKP SRNILLKLHS EYTSITDELE SVCHLIASPT VSLQSNKASL
DRPKTEMSRA EAAALQEKQH LKECEENDYR ILEGLFEARG SIDASVPSYE IGVSVDYSHR
YPLRRETAIE LSPSKPAAEG GAIGAVIAGD SSDTSGAASS GFQLKHERPW QRNSSMEQQS
YQSPLVPTRA TSDFLNPPYD SSGRLFKKSS ESLQKNSSTD TDYSAHPYRF IKQSSNETNT
SLTGSYNVDT PSLTAEPSLD AGDSHSATGI SVSVGAAGGA AQARYQPKRT ASVGAADGRR
LRDDSSSSLD LTQPAPALPT RPMQLKKQFS MDQGKPLSAQ TNAEASSTEA AAAAGAAAGA
AAGAAGAPVA AKLISTLKPP YTSKLGMNVL KESSSSTEES RDGEPISATT SSSAKSSSTN
LAIPQISTHL VQDEIAKLSS NIKSSTESEK DPPYNETMC
//
