ID A0A0Q9X792_DROMO Unreviewed; 2062 AA.
AC A0A0Q9X792;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Uncharacterized protein, isoform H {ECO:0000313|EMBL:KRG04092.1};
GN Name=Dmoj\GI19939 {ECO:0000313|EMBL:KRG04092.1};
GN ORFNames=Dmoj_GI19939 {ECO:0000313|EMBL:KRG04092.1};
OS Drosophila mojavensis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7230 {ECO:0000313|EMBL:KRG04092.1, ECO:0000313|Proteomes:UP000009192};
RN [1] {ECO:0000313|EMBL:KRG04092.1, ECO:0000313|Proteomes:UP000009192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15081-1352.22 {ECO:0000313|Proteomes:UP000009192};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CH933808; KRG04092.1; -; Genomic_DNA.
DR RefSeq; XP_015018696.1; XM_015163210.1.
DR EnsemblMetazoa; FBtr0426980; FBpp0384632; FBgn0142676.
DR GeneID; 6578541; -.
DR Proteomes; UP000009192; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:UniProt.
DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR Gene3D; 1.20.5.1010; TRPM, tetramerisation domain; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR InterPro; IPR032415; TRPM_tetra.
DR InterPro; IPR037162; TRPM_tetra_sf.
DR PANTHER; PTHR13800:SF1; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR Pfam; PF16519; TRPM_tetra; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009192};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 956..974
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1018..1036
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1085..1106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1165..1185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 176..443
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 958..1190
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1281..1336
FT /note="TRPM tetramerisation"
FT /evidence="ECO:0000259|Pfam:PF16519"
FT REGION 24..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 818..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1508..1531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1757..1869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1882..1925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1991..2024
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2042..2062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2062 AA; 229454 MW; 2B9E1FA6180B5F5C CRC64;
MVIDSPHAAH KYLRRISRDF STVRRFSNTP PVGPATPPPT TAPSVDGADA LPSTPRGIRK
RQRLRKRSSV SSTLSKVLIL NVRDLLRAQP EPTPEHQPRS WIETNFQKRE CIKFIPCPKD
DTKCCCGQAQ ITHQTIAGIE SGSPGDTWLP TKHTRPQPTD AYGTIEFQGG AHPTKAQYVR
LSFDTRPELL VQLFTKEWNL ELPKLLITVQ GGKANFDLQA KLKKEIRKGL LKAAKTTGAW
IFTGGTNTGV TKQVGDALLL EGQQRTGRVV SIGIAPWGIV ERNHELLGHN REVPCHSISS
PRSKLAVLNN RHAYFLLVDN GTMAKYGAEL ILRRKLEKFI SNLKLHPFTH SSTPVVCLVI
EGGTNTIRAV LEYVTDSPPV PVVVCDGSGR AADLLAFVHK YASDGEEQPV LESMRDYLIG
TIQKTFEVGL DQAEKLYQEL LQCTRNKNLI TVFRIQEKPE GEAQELDQTI LTALFKSQHL
SPPEQLSLAL TWNRVDIARS EIFVYGQEWP NGALDEAMMQ ALEHDRIDFV KLLLENGVSM
KKFLTIPRLE ELYNTKHGPA NTLGYILRDV RPHIPKGYIY TLHDIGLVIN KLMGGAYRSY
YTRRKFRPIY AKVMNSYANA CRKSSTYQYQ RYAGANSLSL VTGLLPFTTE MALFEFPFNE
LLIWAVLTKR QQMALLMWTH GEEALAKSLV ACKLYKAMAH EAAEDDLDTE IYEELRSYAK
EFESKGNKLL DFSYRQDAEK AQRLLTCELH SWSNQSCLSL AVAANHRALL AHPCSQVILA
DLWMGGLRTR KNTNFKVILG LIMPFYIRQL DFKSKEELQQ MPQTEEEHLE NQNLDNDDSD
RSQPDAENAL LKAKRSISLR YRKGAGSNNR DKALLADTYS VRDTKVHENG KVNLTAGAEE
PPSKVSLTDS DPSQFREFFH LSEFTNEIKQ HQPLRLKKKF YEFYTAPITK FWADSIAYMF
FLIMFSFTVL VKMGPIPRWQ EWYSIAYITT LGFEKVREIV SSEPVAITHK FSVWAWNMWN
PCDGAAIILF LIGLAFRFRP NTMDIGRVIY CVDSIYWYLR ILNILGVNKY LGPLVTMMGK
MVKNMIYFVV LLAVVLMSFG VSRQAILYPN NEPTWRLIRE VTYQPYFMLY GEVFADDIDP
PCGEDPRQPA CVTGHWVTPI TMSMYLLIAN ILLINLLIAV FNNIFNEVNS VSHQVWMFQR
FTVVMEYQQK PVLPPPFIAF CHFYSLLKYC VRKAKGLEVQ RDNGLKLFLE KDDLERLYDF
EEECVEGFFH EQEIILNQST DERVKNTTER VETMAQKIED INQKENIQTA TVQNIEFRLR
KMEESSEQIL SHLGVIHRFM SAHTTGNEEL LRGSVMNIPG EMHRMRTISM SDNEGSGGAG
GGGGGSGGGG GGGGGIGVGG SAGIAASLGL GAALTLNSLQ VNNRRRFNRS LTEVRPDAYI
LDEGTHFEVV PLPEEPDEVV KSREALNEQM VRKASMQSEA DSDIYLPLSQ RPSTCDTVKR
TPYVTVRQDT GASTESKDTL TPMGNNDDDQ TLVGGDNSDD AAPDMTFEAA RHRALRQRTV
SLCRRNSETY SLAGADINRS HISLNQLTTL SRRQMSLTHS EPDSDKDMPP VPQTGKSVLH
AKPSRNILLK LHSEYTSITD ELESVCHLIA SPTVSLQSNK ASLDRPKTEM SRAEAAALQE
KQHLKECEEN DYRILEGLFE ARGSIDASVP SYEIGVSVDY SHRYPLRRET AIELSPSKPA
AEGGAIGAVI AGDSSDTSGA ASSGFQLKHE RPWQRNSSME QQSYQSPLVP TRATSDFLNP
PYDSSGRLFK KSSESLQKNS STDTDYSAHP YRFIKQSSNE TNTSLTGSYN VDTPSLTAEP
SLDAGDSHSA TGISVSVGAA GGAAQARYQP KRTASVGAAD GRRLRDDSSS SLDLTQPAPA
LPTRPMQLKK QFSMDQGKPL SAQTNAEASS TEAAAAAGAA AGAAAGAAGA PVAAKLISTL
KPPYTSKLGM NVLKESSSST EESRDGEPIS ATTSSSAKSS STNLAIPQIS THLVQDEIAK
LSSNIKSSTE SEKDPPYNET MC
//
