ID A0A0Q9XCN3_DROMO Unreviewed; 1393 AA.
AC A0A0Q9XCN3;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KRG02628.1};
GN Name=Dmoj\GI14779 {ECO:0000313|EMBL:KRG02628.1};
GN ORFNames=Dmoj_GI14779 {ECO:0000313|EMBL:KRG02628.1};
OS Drosophila mojavensis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7230 {ECO:0000313|EMBL:KRG02628.1, ECO:0000313|Proteomes:UP000009192};
RN [1] {ECO:0000313|EMBL:KRG02628.1, ECO:0000313|Proteomes:UP000009192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15081-1352.22 {ECO:0000313|Proteomes:UP000009192};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|ARBA:ARBA00004201}.
CC -!- SIMILARITY: Belongs to the WD repeat EDC4 family.
CC {ECO:0000256|ARBA:ARBA00009639}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH933807; KRG02628.1; -; Genomic_DNA.
DR RefSeq; XP_015020335.1; XM_015164849.1.
DR GeneID; 6575843; -.
DR KEGG; dmo:Dmoj_GI14779; -.
DR eggNOG; KOG1916; Eukaryota.
DR InParanoid; A0A0Q9XCN3; -.
DR OrthoDB; 2911539at2759; -.
DR Proteomes; UP000009192; Unassembled WGS sequence.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0031087; P:deadenylation-independent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR Gene3D; 6.10.140.270; -; 1.
DR Gene3D; 1.10.220.100; conserved c-terminal region of ge- 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR045152; EDC4-like.
DR InterPro; IPR049404; EDC4_C.
DR InterPro; IPR044938; EDC4_C_sf.
DR InterPro; IPR032401; EDC4_WD40.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR15598; ENHANCER OF MRNA-DECAPPING PROTEIN 4; 1.
DR PANTHER; PTHR15598:SF5; ENHANCER OF MRNA-DECAPPING PROTEIN 4; 1.
DR Pfam; PF21289; EDC4_C; 1.
DR Pfam; PF16529; Ge1_WD40; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000009192};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 131..470
FT /note="Enhancer of mRNA-decapping protein 4 WD40 repeat
FT region"
FT /evidence="ECO:0000259|Pfam:PF16529"
FT DOMAIN 1260..1380
FT /note="Enhancer of mRNA-decapping protein 4 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21289"
FT REGION 474..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 844..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 928..972
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1199..1226
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 844..864
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1393 AA; 155042 MW; 72299156366EECDB CRC64;
MLIALFALAH LPIFRKPLQS LSRCGKGKSN TTIATTTTTS NAHLAALTSN CNSQTTGDII
LIGTRLNMSN SNEQDKGAAE AVGAIVAANG NQTDPKKIEI INFKPFDKQC CYSIKTNHTR
VYGCGGSHTR GSSKVKLKNV VDYKWEHKYY YPGHLVAVHR DGKHLAYAIN VNNKATGMEG
MVRVCNTSTS QRALIKGMNG EVLDLQFAHS ERERILAVID MCSLFVYKID LIDSNLICKL
VLKVDDPIAN YVPEYDMVSW CPYVTNGNSS NNNTSANTAT GHEEDDENQL LIWSRSKQFQ
CFNVRMIISE YGRGQIKPSS LETGYLKIEE DTLITCAALS PDGTTVAAAC LDGLVRFYQI
YLYDVRNHRC LHEWKPHDGK PVASLFFLDN INKPVEDAYW QYVITTSDHN TEIKLWNCSL
WECLQTINVM ASVPSSVQPS MFIAGIDRSA NYLVISSLDA LAVYVMQISS CGGNEQGSDS
GDSENGCDVH GSSSSIAGSN DPSIRIQNIA EFKLSSGILS FSIVNASMRR LKSTNESYYP
FEEPDDYDDE SNATTDALVV HMFVVQAKSL QECQIIYQPC KPTRSLNSSK SSAKKRSLSP
DNLLHVTEIK QEQLSNSPNS HNSSTGSGSS AVPLDALFGK SKRNSVGSVV SVAIAAAAAP
SAILQEPATT NKSRSASPQY GSNYSQLNLM TPDAFSASAA SIVLVNRDGA ETNTTTTTDQ
SPINSQVLQT LRMLATVTAK GTETANTNLL NLINNTHIED REQQKLKEQT DARKKFIAID
RNPERNAAEN LASGGSSPSR EVQEIMATQE DTDDYEPELV DIEYDEDNPY FMICKTENKT
DNEITNSSTV EEAATTSNWL PQDAKLPTKK SAELQNAAQI MSQAVQHKNN GNVPPTLGSN
SSNSNNNTTT TLNSSNNNNS SNCSHPIVES ATEVNAKLEQ LLEMVKAQSE QLNKLEHEIN
KVQQQQQQQL LQQSSGSTAA ALQPKSVNEL AYKIEMQLSK LMEQYLKRYE NEHKKKLTEF
LHARETQNRE LRDSVLQVLN QYVMNHFTDI IGNVLNMELQ RQLLPRVNAK MDQLQNQMQL
EIVQKLNVFD KTVKENIAQV CKSKQFLDAF GKSVLIGVQT SLQTAFIESM SSTLIPAYEK
SSQNMFKQLH EAFSVGIKDF MVEFNAYLQH IPQPHNGEEL SNKLGLLKQL VETNLLKHRT
ELTDAMLETQ REVKSLEILL ARQVQETIRT ELRKHMDNQS MALRSQAATP APTYDLRESI
KQLLLANHIN KAFHQALLAN DLNLVEFTLR NTDRMQVFTP DGCRLEQKVL LSLIQQISAD
MSNHNELKQS YLNEALLAIN MSDPITREHA PKVLSELYRN CQLFIKNCPK SPQCSNVRLL
IAMCSATYRD QFK
//
