ID A0A0Q9XCU6_DROMO Unreviewed; 2117 AA.
AC A0A0Q9XCU6;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Uncharacterized protein, isoform G {ECO:0000313|EMBL:KRG01672.1};
GN Name=Dmoj\GI22653 {ECO:0000313|EMBL:KRG01672.1};
GN ORFNames=Dmoj_GI22653 {ECO:0000313|EMBL:KRG01672.1};
OS Drosophila mojavensis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7230 {ECO:0000313|EMBL:KRG01672.1, ECO:0000313|Proteomes:UP000009192};
RN [1] {ECO:0000313|EMBL:KRG01672.1, ECO:0000313|Proteomes:UP000009192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15081-1352.22 {ECO:0000313|Proteomes:UP000009192};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SIMILARITY: Belongs to the TOG/XMAP215 family.
CC {ECO:0000256|ARBA:ARBA00025722}.
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DR EMBL; CH933806; KRG01672.1; -; Genomic_DNA.
DR RefSeq; XP_015022778.1; XM_015167292.1.
DR EnsemblMetazoa; FBtr0431277; FBpp0388569; FBgn0145381.
DR GeneID; 6574149; -.
DR OrthoDB; 5477703at2759; -.
DR Proteomes; UP000009192; Unassembled WGS sequence.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0099080; C:supramolecular complex; IEA:UniProt.
DR GO; GO:0061863; F:microtubule plus end polymerase; IEA:InterPro.
DR GO; GO:0051010; F:microtubule plus-end binding; IEA:InterPro.
DR GO; GO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity; IEA:InterPro.
DR GO; GO:0046785; P:microtubule polymerization; IEA:InterPro.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 5.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR045110; XMAP215.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR12609:SF0; CYTOSKELETON-ASSOCIATED PROTEIN 5; 1.
DR PANTHER; PTHR12609; MICROTUBULE ASSOCIATED PROTEIN XMAP215; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 4.
DR SMART; SM01349; TOG; 5.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009192};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..227
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 306..545
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 478..516
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 616..849
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 883..1118
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1214..1450
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 545..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 842..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1157..1176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1445..1466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..613
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2117 AA; 235407 MW; 54C2D23AD7093862 CRC64;
MAEDTEYKKL PIEERCVHKL WKARVDGYEE AAKIFRELDD ERSPEWSKYA GLIKKMVVDS
NALAQEKGLE AALIFVENSS LAGRTVGDVM SGIVQKCIAA PKTKTKELAV QVTLMYVEIE
KHEAVVEELV KGMDHKNPKI VAACVAATTQ AMREFGSKVI GVKQFIKKLA PLMADRDKAV
RDETKQLAVE SYRWIGAVMK THISSLPQVT IKELEDEFDK LKGDRAEPTR YLKSQQEKQA
KIADEAAAGA EDAYDDNISP PSRKSIKKYR KQVRKERSIF CSPKCAYRSL LDEDGEAGTE
DVDPMDLIDP VDILSKMPKD FYDKLDEKKW TLRKESLDAL EKLLTENPKL EAGEYGALVS
ALKKVITKDS NVVLVALAGK CLAMLAKGLS KRFSTYATAC VPALLEKFKE KKPNVVNALR
EAMDAIYSST TLEAQQEHIV EALTNKNPSV KSETALFLAR ALCRTQPTAL NKKLIKLLTT
SLVKTLNESD PTVRDSSAEA LGTLMKLVSE KALAPLLLDV DALKMVKIKE CHDKAEIKIK
VAAPKKEARP ATAPTTKAAA VVSKPTGGST EPKAVTRPAT SGARKTLKKP GTGATGGAPA
ATNKTASSKA TVTERELTPE EIQEKADALL SADILNGLVD SNWKNRLAAM EQLLSQIPSY
DAQQPGLSQT LVRTISGRKP GLKEMNFQVL KLKLDAIRCV AENFPLTAVT VDHVVNEITE
KLADAKNGGA ASDALSALSE ATKLEQVVSK VLSFALDQKS PKVQAEAFNW INKAIVEFGF
KVQPKILIED VRKGVQSTNP TVRGAAIQLV GTMTMYMGNA VMLFFDGEKP ALKSQIQAEF
NKNLGEKPPR PVRGVTSSAN LEDANDDDEG NGGASPEPMN LADLLPRVDI SSQITESLLK
EMSDKDWKTR NEGLTKLQVI ISEAKLIKPT IGDLAPALAH RLLDSNAKIA QTALSICEQL
STAMGAGCRS HVRVLFPGFL HALGDNKSFV RAAGLNCMNS FGEQGGYKEF FENEMIADAL
KSGSPLLKAE LWAWLAEKMP LLPPKSISKE ELTSMVPHLY AHICDRNAEV RKNANEAVLA
VMIHLGYEAM ARALDKQKPA SKKDILAALE KARPNLPVKP LPKGKQQAPI PEETKKVVRS
GGGGAAAQKQ IATKAANAAG DKATTTAASR KKEEDVDTSP LLAVNNMKNQ RLIDEQKMRV
LKWTFTTPRE EFTDLLRDQM TTANVNKALM ANMFHDDFRY HLKVIEQLSE DLPNNRKALI
CNLDLILKWL TLRFYDTNPS VLIKGLEYLA QVFQMLVEME YMMAENEGSS FVPHLLLKIG
DPKDAVRNGV RRVLRQINLL YPFTKVFSYV MEGLKSKNAR QRTECLDELT FLIENYGLGI
CQPSQQVALK EIARQISDRD NSVRNAALNC IVMAYFLAGE KIYKLIGQLN EKDLSMLDER
IKRAKKTRKP AVPAEMPPGL KPPTQVVQQD SIEIEDAVGN GSEELPPPEE EGRQQPEFNE
CGQSNRLAER SATSAKTILH SLHRQATFDQ APSAQVQQLQ QQLQLHQQQV AQQRTTGPFG
LDPQVMAEIE KDWVRVDQMV FKELPTVDIS LLYEPIKVIP TRDGFQYPQE KFDRLIARSR
HIQQNLTTSP QSNPTMSSGI SPYRSPLRMQ PHLTSQPHLE SNIPNLAEML PKHDPKLVKI
IKAVSSTDTL EARAAINELT EIIEAPEKQA VLRDYEEIFI QNVLAQLKNL SQMPIAQAQV
VYQPLLSILY TFFNANILGK TLSIACIKNL MSALLHLLAD QKLNSGDDCQ YNKVINGICL
KVLDKVNFTN IYCALIRLLR ETCPVAGLPK FTDLLMKCIW RNIKMLPERT NELNYDAVIL
EVHEFMLALP STWWQNRPSD TPLRTVKTII HNMAKVKGNG ILQHLNQIPT HSELHTYLIR
ILKNFQKDGT VSGGAGVSPQ RQQYHSKDVD GKRISHQTHD TVSQIFKLIS DKDTKQQGLQ
KLFDFKQQNP DIDLSTFLQG ASVTFHRYIE EGLAEIERNQ NAGTQAPDNR TDVNYQNASH
DPDYWMARLQ NLMSARQNGD NGSNMLDNRV ADENLCLNSM NSQKVSLIRQ EKPELSPNRL
QHIQAKLAQI KKENHAQ
//
