ID A0A0Q9XIF8_DROMO Unreviewed; 2076 AA.
AC A0A0Q9XIF8;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=Uncharacterized protein, isoform M {ECO:0000313|EMBL:KRG04097.1};
GN Name=Dmoj\GI19939 {ECO:0000313|EMBL:KRG04097.1};
GN ORFNames=Dmoj_GI19939 {ECO:0000313|EMBL:KRG04097.1};
OS Drosophila mojavensis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7230 {ECO:0000313|EMBL:KRG04097.1, ECO:0000313|Proteomes:UP000009192};
RN [1] {ECO:0000313|EMBL:KRG04097.1, ECO:0000313|Proteomes:UP000009192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15081-1352.22 {ECO:0000313|Proteomes:UP000009192};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CH933808; KRG04097.1; -; Genomic_DNA.
DR RefSeq; XP_015018701.1; XM_015163215.1.
DR EnsemblMetazoa; FBtr0431127; FBpp0388438; FBgn0142676.
DR InParanoid; A0A0Q9XIF8; -.
DR Proteomes; UP000009192; Unassembled WGS sequence.
DR GO; GO:0034703; C:cation channel complex; IEA:EnsemblMetazoa.
DR GO; GO:0097682; F:intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity; IEA:EnsemblMetazoa.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:EnsemblMetazoa.
DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR Gene3D; 1.20.5.1010; TRPM, tetramerisation domain; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR InterPro; IPR032415; TRPM_tetra.
DR InterPro; IPR037162; TRPM_tetra_sf.
DR PANTHER; PTHR13800:SF1; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR Pfam; PF16519; TRPM_tetra; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009192};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 970..988
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1032..1050
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1099..1120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1179..1199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 176..457
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 972..1204
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1295..1350
FT /note="TRPM tetramerisation"
FT /evidence="ECO:0000259|Pfam:PF16519"
FT REGION 24..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 832..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1522..1545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1771..1883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1896..1939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2005..2038
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2056..2076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2076 AA; 230924 MW; 0C03FA69576276BF CRC64;
MVIDSPHAAH KYLRRISRDF STVRRFSNTP PVGPATPPPT TAPSVDGADA LPSTPRGIRK
RQRLRKRSSV SSTLSKVLIL NVRDLLRAQP EPTPEHQPRS WIETNFQKRE CIKFIPCPKD
DTKCCCGQAQ ITHQTIAGIE SGSPGDTWLP TKHTRPQPTD AYGTIEFQGG AHPTKAQYVR
LSFDTRPELL VQLFTKEWNL ELPKLLITVQ GGKANFDLQA KLKKEIRKGL LKAAKTTGAW
IFTGGTNTGV TKQVGDALLL EGQQRTGRVV SIGIAPWGIV ERNHELLGHN REVPCHSISS
PRSKLAVLNN RHAYFLLVDN GTMAKYGAEL ILRRKLEKFI SNLKLHPSRG TVVRSSKLCT
KLTHSSTPVV CLVIEGGTNT IRAVLEYVTD SPPVPVVVCD GSGRAADLLA FVHKYASDGE
EQPVLESMRD YLIGTIQKTF EVGLDQAEKL YQELLQCTRN KNLITVFRIQ EKPEGEAQEL
DQTILTALFK SQHLSPPEQL SLALTWNRVD IARSEIFVYG QEWPNGALDE AMMQALEHDR
IDFVKLLLEN GVSMKKFLTI PRLEELYNTK HGPANTLGYI LRDVRPHIPK GYIYTLHDIG
LVINKLMGGA YRSYYTRRKF RPIYAKVMNS YANACRKSST YQYQRYAGAN SLSLVTGLLP
FTTEMALFEF PFNELLIWAV LTKRQQMALL MWTHGEEALA KSLVACKLYK AMAHEAAEDD
LDTEIYEELR SYAKEFESKG NKLLDFSYRQ DAEKAQRLLT CELHSWSNQS CLSLAVAANH
RALLAHPCSQ VILADLWMGG LRTRKNTNFK VILGLIMPFY IRQLDFKSKE ELQQMPQTEE
EHLENQNLDN DDSDRSQPDA ENALLKAKRS ISLRYRKGAG SNNRDKALLA DTYSVRDTKV
HENGKVNLTA GAEEPPSKVS LTDSDPSQFR EFFHLSEFTN EIKQHQPLRL KKKFYEFYTA
PITKFWADSI AYMFFLIMFS FTVLVKMGPI PRWQEWYSIA YITTLGFEKV REIVSSEPVA
ITHKFSVWAW NMWNPCDGAA IILFLIGLAF RFRPNTMDIG RVIYCVDSIY WYLRILNILG
VNKYLGPLVT MMGKMVKNMI YFVVLLAVVL MSFGVSRQAI LYPNNEPTWR LIREVTYQPY
FMLYGEVFAD DIDPPCGEDP RQPACVTGHW VTPITMSMYL LIANILLINL LIAVFNNIFN
EVNSVSHQVW MFQRFTVVME YQQKPVLPPP FIAFCHFYSL LKYCVRKAKG LEVQRDNGLK
LFLEKDDLER LYDFEEECVE GFFHEQEIIL NQSTDERVKN TTERVETMAQ KIEDINQKEN
IQTATVQNIE FRLRKMEESS EQILSHLGVI HRFMSAHTTG NEELLRGSVM NIPGEMHRMR
TISMSDNEGS GGAGGGGGGS GGGGGGGGGI GVGGSAGIAA SLGLGAALTL NSLQVNNRRR
FNRSLTEVRP DAYILDEGTH FEVVPLPEEP DEVVKSREAL NEQMVRKASM QSEADSDIYL
PLSQRPSTCD TVKRTPYVTV RQDTGASTES KDTLTPMGNN DDDQTLVGGD NSDDAAPDMT
FEAARHRALR QRTVSLCRRN SETYSLAGAD INRSHISLNQ LTTLSRRQMS LTHSEPDSDK
DMPPVPQTGK SVLHAKPSRN ILLKLHSEYT SITDELESVC HLIASPTVSL QSNKASLDRP
KTEMSRAEAA ALQEKQHLKE CEENDYRILE GLFEARGSID ASVPSYEIGV SVDYSHRYPL
RRETAIELSP SKPAAEGGAI GAVIAGDSSD TSGAASSGFQ LKHERPWQRN SSMEQQSYQS
PLVPTRATSD FLNPPYDSSG RLFKKSSESL QKNSSTDTDY SAHPYRFIKQ SSNETNTSLT
GSYNVDTPSL TAEPSLDAGD SHSATGISVS VGAAGGAAQA RYQPKRTASV GAADGRRLRD
DSSSSLDLTQ PAPALPTRPM QLKKQFSMDQ GKPLSAQTNA EASSTEAAAA AGAAAGAAAG
AAGAPVAAKL ISTLKPPYTS KLGMNVLKES SSSTEESRDG EPISATTSSS AKSSSTNLAI
PQISTHLVQD EIAKLSSNIK SSTESEKDPP YNETMC
//
