ID A0A0Q9XLC0_9STAP Unreviewed; 614 AA.
AC A0A0Q9XLC0;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Sodium:proton antiporter {ECO:0000313|EMBL:KRG08981.1};
GN ORFNames=ACA31_07375 {ECO:0000313|EMBL:KRG08981.1};
OS Staphylococcus sp. NAM3COL9.
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=1667172 {ECO:0000313|EMBL:KRG08981.1, ECO:0000313|Proteomes:UP000051126};
RN [1] {ECO:0000313|EMBL:KRG08981.1, ECO:0000313|Proteomes:UP000051126}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NA309 {ECO:0000313|EMBL:KRG08981.1,
RC ECO:0000313|Proteomes:UP000051126};
RA Gaiero J., Nicol R., Habash M.;
RT "Genome sequencing project of Staphylococcus sp. NA309.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRG08981.1}.
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DR EMBL; LGPC01000014; KRG08981.1; -; Genomic_DNA.
DR RefSeq; WP_057512686.1; NZ_LGPC01000014.1.
DR AlphaFoldDB; A0A0Q9XLC0; -.
DR PATRIC; fig|1667172.3.peg.1487; -.
DR OrthoDB; 9793589at2; -.
DR Proteomes; UP000051126; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR43562:SF1; NA(+)_H(+) ANTIPORTER YJBQ-RELATED; 1.
DR PANTHER; PTHR43562; NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02080; TrkA_C; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 1.
DR PROSITE; PS51202; RCK_C; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 57..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 402..516
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
FT DOMAIN 531..612
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 614 AA; 68881 MW; 30BB168BF0E11047 CRC64;
MEFLSLVIVV LAAFLTPILV NRLRVSFLPV VVAEILMGII IGRSFLNLVE RDAMLNILST
LGFIFLMFLS GLEIDFKAFK KDKSSTAQEE KSKKQEPGHL QLAVIVFMAI MIISIVFAYM
FKWFGLIDDV LLMVIIISTI SLGVVVPTLK EMNIMRTTIG QFILLVAVLA DLVTMILLTG
YGAIHASGNT SLWLVGSLVV FTIIFYFLGG IFKKAQFLQI LMDGTTQIGI RAVFALILLL
VALAEGVGAE NILGAFLAGV VVSLLGPDED MVEKLDSFGY GFFIPIFFIM VGVDLNIPEL
IKEPSLLLII PFLILAFLIS KLVPVFYIRR WFDMKTTISS AFLLTSTLSL VIASAKIAEQ
LGTISTEISG ILILSSVITC VFVPIVFKKM FPMPDEATRQ IEVSLIGKNE LTIPIAQNLT
SQLYQVSLYY RNDLSDKRKL SDAISMIEIA DYEEELLERL GLFERNIVVC STNDDDINRK
VALMAKEHGV KRVICRLESS SSDIELQKEG IEVFSSYLSN KILLKGLIET PNMLNLLSNV
ETSLYEIAML NHQYDQIQLR NFPFDGDIIF VRIIRNNESI VPHGDTQLRY RDRVIVTGSK
EYVDELKREL EFYY
//
